Investigating obesity induced gut microbiome changes in the development of multiple myeloma

研究肥胖引起的多发性骨髓瘤发展中肠道微生物组的变化

• 批准号: 2893917
• 金额: --
• 依托单位: University of East Anglia
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2893917
• 关键词: Investigating; obesity; induced; gut; microbiome

Background: Approximately 6,000 people are diagnosed with multiple myeloma (MM) in the UK each year. Presently myeloma remains incurable with a median survival of about 50%. MM is a cancer of plasma cells, which are considered the backbone of the adaptive immune system due to their ability to produce immunoglobulins and fight microbial infections. There are many associated risk factors for MM, however, obesity has consistently been recognized as a risk factor. In this project with access to human samples from MM patients, the aim of this study is to determine the role of obesity induced changes in gut microbiota on driving/influencing the progression of MM.Research methodology: Gaining a better understanding of the mechanisms regulating MM development in the context of its local bone marrow but also the wider organ system will enable us to propose strategies for therapeutic intervention. Therefore, the aim of this project is to define the metabolic mechanisms underpinning MM progression. Specifically, we will determine the role of changes in gut microbiota induced by obesity in these processes.

背景：英国每年约有 6,000 人被诊断患有多发性骨髓瘤 (MM)。目前，骨髓瘤仍无法治愈，中位生存率约为 50%。多发性骨髓瘤是一种浆细胞癌，浆细胞因其产生免疫球蛋白和抵抗微生物感染的能力而被认为是适应性免疫系统的支柱。多发性骨髓瘤有许多相关的危险因素，然而，肥胖一直被认为是一个危险因素。在这个项目中，我们获取了多发性骨髓瘤患者的人体样本，其目的是确定肥胖引起的肠道微生物群变化在驱动/影响多发性骨髓瘤进展中的作用。研究方法：更好地了解调节多发性骨髓瘤的机制局部骨髓以及更广泛的器官系统的发育将使我们能够提出治疗干预策略。因此，该项目的目的是确定支持 MM 进展的代谢机制。具体来说，我们将确定肥胖引起的肠道微生物群变化在这些过程中的作用。