Course of psychopathology in female youth: Analysis with extant longitudinal data

女性青年精神病理学课程：现有纵向数据分析

• 批准号: 7238188
• 负责人: JOSEPH BIEDERMAN
• 金额: $ 8.75万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2009-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7238188
• 关键词: Academic Medical Centers; Address; Adolescence; Age; Age of Onset; Anxiety Disorders; Arts; Attention deficit hyperactivity disorder; Bipolar Disorder; Blinded; Characteristics; Child; Childhood; Clinical; Cognitive; Communities; Comorbidity; Condition; Conduct Disorder; Conflict (Psychology); Data; Data Analyses; Data Collection; Data Set; Data Sources; Databases; Development; Diagnostic; Disease; Disease remission; Eating Disorders; Exhibits; Exposure to; Family; Family Study; Family history of; Female; First Degree Relative; Funding; Goals; Impairment; Individual; Interview; Knowledge; Learning Disabilities; Literature; Major Depressive Disorder; Measurement; Measures; Mental Depression; Mental disorders; Neuropsychological Tests; Numbers; Outcome; Outcome Measure; Patients; Pattern; Perinatal; Population; Prevention intervention; Preventive Intervention; Psychiatrist; Psychopathology; Public Health; Research; Research Priority; Resources; Risk; Risk Factors; Sampling; Science; Selection Bias; Siblings; Social Class; Structure; Symptoms; Techniques; Testing; Time; Uncertainty; United States National Institutes of Health; Urination; Women' s Health; Work; Youth; aged; boys; case control; clinically significant; cost effectiveness; design; disorder control; family genetics; follow-up; functional disability; functional outcomes; girls; improved; intervention program; male; outcome forecast; pediatrician; proband; prospective; psychiatric disability; psychosocial; teacher; transmission process; treatment planning; young adult

DESCRIPTION (provided by applicant): Although attention-deficit/hyperactivity disorder (ADHD) is more prevalent in boys than girls, little doubt exists that ADHD is also an important cause of psychiatric disability in girls. Despite this, the scientific literature on females with ADHD is scarce, and mostly cross-sectional. Thus, large-scale studies examining the course and outcome of psychopathology in ADHD in girls are sorely needed. Such information can inform patients, families, teachers and clinicians and facilitate prevention and intervention efforts for females with ADHD, an understudied population. We propose a data analysis project that utilizes an existing longitudinal database to address these questions. The overall goal of this application is to use longitudinal measurements, a multigenerational perspective and an extensive assessment of multiple domains of functioning to investigate the developmental course and outcome of psychopathology in female youth with and without ADHD. Our specific aims are to: 1) examine the risk for psychopathology associated with ADHD across development; 2) describe the clinical characteristics of psychopathology in a sample of ADHD girls; 3) estimate the effect of antecedent risk factors on psychopathology in a sample of ADHD girls; and 4) to estimate the effect of psychopathology on subsequent functional outcomes in a sample of ADHD girls. The psychopathological conditions to be examined are: conduct disorder, major depression, bipolar disorder, anxiety disorders, and eating disorders. We will use an existing data source that will provide us with ample statistical power and considerable cost-effectiveness. The dataset is comprised of a five-year prospective case-control family-genetic study of female youth with (n=140) and without (n=122) ADHD, aged 6-18 years at baseline, consecutively ascertained from either community pediatricians or psychiatrists at an academic medical center. At the five-year follow-up, 123 (88 percent) and 112 (92 percent) of the ADHD and control children, respectively, were re-assessed at a mean age of 16.7 years. This study used blinded structured psychiatric diagnostic interviews, cognitive and neuropsychological tests and psychosocial and global functioning measures to assess the probands and their first-degree relatives. State of the art statistical techniques will be employed. A better understanding of the predictors, course and outcome of psychopathology among girls with ADHD has important clinical and public health implications. Such knowledge would alert clinicians to the importance of recognizing psychiatric comorbid disorders in girls with ADHD for treatment planning and forecasting prognosis, and could help design improved preventive and intervention programs. From a public health perspective, the ability to predict the course of psychopathology in girls with ADHD could help focus limited societal resources on those at higher risk for persistent illness with complicated outcomes.

描述（由申请人提供）：虽然注意力缺陷/多动障碍 (ADHD) 在男孩中比女孩更常见，但毫无疑问 ADHD 也是女孩精神残疾的重要原因。尽管如此，关于女性多动症的科学文献仍然很少，而且大多是横截面的。因此，迫切需要大规模研究来检验女孩多动症的精神病理学过程和结果。此类信息可以为患者、家庭、教师和临床医生提供信息，并促进对患有多动症的女性（尚未得到充分研究）的预防和干预工作。我们提出了一个数据分析项目，利用现有的纵向数据库来解决这些问题。该应用程序的总体目标是使用纵向测量、多代视角和对多个功能领域的广泛评估来调查患有和不患有多动症的女性青少年的精神病理学发展过程和结果。我们的具体目标是：1）检查与多动症相关的精神病理学风险在整个发展过程中； 2）描述多动症女孩样本的精神病理学临床特征； 3) 评估 ADHD 女孩样本中先前的危险因素对精神病理学的影响； 4) 评估精神病理学对 ADHD 女孩样本随后功能结果的影响。需要检查的精神病理状况包括：品行障碍、重度抑郁症、双相情感障碍、焦虑症和饮食失调。我们将使用现有的数据源，该数据源将为我们提供充足的统计能力和相当大的成本效益。该数据集由一项为期五年的前瞻性病例对照家庭遗传学研究组成，研究对象为患有 (n=140) 和不患有 (n=122) ADHD 的女性青少年，基线年龄为 6-18 岁，连续由社区儿科医生或社区儿科医生确定。学术医疗中心的精神科医生。在五年的随访中，分别有 123 名（88%）和 112 名（92%）ADHD 儿童和对照组儿童在平均年龄 16.7 岁时接受了重新评估。这项研究使用盲法结构化精神病学诊断访谈、认知和神经心理学测试以及心理社会和整体功能测量来评估先证者及其一级亲属。将采用最先进的统计技术。更好地了解多动症女孩精神病理学的预测因素、病程和结果具有重要的临床和公共卫生意义。这些知识将提醒临床医生认识到患有多动症的女孩的精神共病对于治疗计划和预测预后的重要性，并有助于设计改进的预防和干预计划。从公共卫生的角度来看，预测患有多动症的女孩的精神病理学过程的能力可以帮助将有限的社会资源集中到那些患有持续性疾病且结果复杂的高风险人群上。