Course of psychopathology in female youth: Analysis with extant longitudinal data

女性青年精神病理学课程：现有纵向数据分析

• 批准号: 7238188
• 负责人: JOSEPH BIEDERMAN
• 金额: $ 8.75万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2009-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7238188
• 关键词: Academic Medical Centers; Address; Adolescence; Age; Age of Onset; Anxiety Disorders; Arts; Attention deficit hyperactivity disorder; Bipolar Disorder; Blinded; Characteristics; Child; Childhood; Clinical; Cognitive; Communities; Comorbidity; Condition; Conduct Disorder; Conflict (Psychology); Data; Data Analyses; Data Collection; Data Set; Data Sources; Databases; Development; Diagnostic; Disease; Disease remission; Eating Disorders; Exhibits; Exposure to; Family; Family Study; Family history of; Female; First Degree Relative; Funding; Goals; Impairment; Individual; Interview; Knowledge; Learning Disabilities; Literature; Major Depressive Disorder; Measurement; Measures; Mental Depression; Mental disorders; Neuropsychological Tests; Numbers; Outcome; Outcome Measure; Patients; Pattern; Perinatal; Population; Prevention intervention; Preventive Intervention; Psychiatrist; Psychopathology; Public Health; Research; Research Priority; Resources; Risk; Risk Factors; Sampling; Science; Selection Bias; Siblings; Social Class; Structure; Symptoms; Techniques; Testing; Time; Uncertainty; United States National Institutes of Health; Urination; Women' s Health; Work; Youth; aged; boys; case control; clinically significant; cost effectiveness; design; disorder control; family genetics; follow-up; functional disability; functional outcomes; girls; improved; intervention program; male; outcome forecast; pediatrician; proband; prospective; psychiatric disability; psychosocial; teacher; transmission process; treatment planning; young adult

DESCRIPTION (provided by applicant): Although attention-deficit/hyperactivity disorder (ADHD) is more prevalent in boys than girls, little doubt exists that ADHD is also an important cause of psychiatric disability in girls. Despite this, the scientific literature on females with ADHD is scarce, and mostly cross-sectional. Thus, large-scale studies examining the course and outcome of psychopathology in ADHD in girls are sorely needed. Such information can inform patients, families, teachers and clinicians and facilitate prevention and intervention efforts for females with ADHD, an understudied population. We propose a data analysis project that utilizes an existing longitudinal database to address these questions. The overall goal of this application is to use longitudinal measurements, a multigenerational perspective and an extensive assessment of multiple domains of functioning to investigate the developmental course and outcome of psychopathology in female youth with and without ADHD. Our specific aims are to: 1) examine the risk for psychopathology associated with ADHD across development; 2) describe the clinical characteristics of psychopathology in a sample of ADHD girls; 3) estimate the effect of antecedent risk factors on psychopathology in a sample of ADHD girls; and 4) to estimate the effect of psychopathology on subsequent functional outcomes in a sample of ADHD girls. The psychopathological conditions to be examined are: conduct disorder, major depression, bipolar disorder, anxiety disorders, and eating disorders. We will use an existing data source that will provide us with ample statistical power and considerable cost-effectiveness. The dataset is comprised of a five-year prospective case-control family-genetic study of female youth with (n=140) and without (n=122) ADHD, aged 6-18 years at baseline, consecutively ascertained from either community pediatricians or psychiatrists at an academic medical center. At the five-year follow-up, 123 (88 percent) and 112 (92 percent) of the ADHD and control children, respectively, were re-assessed at a mean age of 16.7 years. This study used blinded structured psychiatric diagnostic interviews, cognitive and neuropsychological tests and psychosocial and global functioning measures to assess the probands and their first-degree relatives. State of the art statistical techniques will be employed. A better understanding of the predictors, course and outcome of psychopathology among girls with ADHD has important clinical and public health implications. Such knowledge would alert clinicians to the importance of recognizing psychiatric comorbid disorders in girls with ADHD for treatment planning and forecasting prognosis, and could help design improved preventive and intervention programs. From a public health perspective, the ability to predict the course of psychopathology in girls with ADHD could help focus limited societal resources on those at higher risk for persistent illness with complicated outcomes.

描述（由申请人提供）：尽管注意力缺陷/多动症（ADHD）在男孩中比女孩更普遍，但毫无疑问，ADHD也是女孩精神疾病的重要原因。尽管如此，关于多动症女性的科学文献稀缺，主要是横断面。因此，迫切需要大规模研究，研究女孩心理病理学的过程和结果。这些信息可以通知患者，家庭，教师和临床医生，并促进对女性的预防和干预措施，该女性是ADHD的人口研究。我们提出了一个数据分析项目，该项目利用现有的纵向数据库来解决这些问题。该应用的总体目标是使用纵向测量，多代透视观点以及对多个功能领域的广泛评估，以研究有或没有多动症的女性青年的心理病理学的发育过程和结果。我们的具体目的是：1）检查整个发展中与多动症相关的心理病理学风险； 2）描述ADHD女孩样本中心理病理学的临床特征； 3）估计ADHD女孩样本中先决危险因素对心理病理学的影响； 4）估计心理病理学对ADHD女孩样本中随后的功能结果的影响。待检查的心理病理学疾病是：行为障碍，严重抑郁症，躁郁症，焦虑症和饮食失调。我们将使用现有的数据源，该数据源将为我们提供足够的统计能力和相当大的成本效益。该数据集由一项为期五年的前瞻性病例对照家庭遗传研究（n = 140）的女性（n = 140）和（n = 122）ADHD，在基线时为6-18岁，是从一个学术医疗中心的社区儿科医生或精神病学家的统一确定的。在五年的随访中，分别在平均16.7岁的年龄重新评估了ADHD和对照儿童的123（88％）和112（92％）。这项研究使用了盲目的结构化精神诊断访谈，认知和神经心理学测试以及社会心理和全球功能措施，以评估概率及其一级亲戚。将采用最先进的统计技术。对患有多动症的女孩的预测因子，心理病理学的过程和结果有更好的了解具有重要的临床和公共卫生影响。这些知识将提醒临床医生，注意认识到ADHD女孩的精神病性疾病的重要性，以治疗计划和预测预后，并可以帮助设计改进的预防和干预计划。从公共卫生的角度来看，预测多动症女孩心理病理学进程的能力可能有助于将有限的社会资源集中在患有持续性疾病风险较高的患有复杂结果的人中。