OUTCOME OF ATTENTION DEFICIT HYPERACTIVITY DISORDER

注意力缺陷多动症的结果

• 批准号: 6181890
• 负责人: JOSEPH BIEDERMAN
• 金额: $ 43.76万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-04-01 至 2003-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6181890
• 关键词: academic achievement; adolescence (12-20); age difference; attention deficit disorder; behavioral /social science research tag; child behavior; clinical research; cognition; comorbidity; disease /disorder onset; family genetics; human puberty; human subject; human therapy evaluation; interview; longitudinal human study; mental disorder diagnosis; neuropsychology; outcomes research; prognosis; psychological adaptation; psychotherapy; siblings; social psychology

DESCRIPTION: This proposal intends to follow a group of 117 adolescents with ADHD and a comparable control group for as well as over 100 of their siblings, subjects already followed for five years, for an additional five years. Given the mean age of the sample, this study will provide information about ADHD as subjects mature from adolescence into young adult life. These subjects will be assessed on six domains: psychopathology, cognitive-neuropsychological functioning, school dysfunction, adaptive functioning, treatment interventions and psychosocial adversity. A variety of measures are included in the assessment of each domain. Analytic methods address six issues: variable age of onset of psychiatric illness; nonindependence of observations within families and between time periods; effects of treatment; integration of information across multiple informants; effects of confounding variables; wide age range of the sample at baseline. The investigators will test three general hypotheses: prediction of outcome based on baseline ADHD (or sibling of ADHD); prediction of outcome based on comorbidity; prediction of outcome and comorbidity based on DSM-IV subtypes.

描述：本提案旨在追踪 117 名青少年 患有注意力缺陷多动障碍（ADHD）的患者和一个可比的对照组以及超过 100 名患者 兄弟姐妹，受试者已被跟踪五年，另外五年 年。 考虑到样本的平均年龄，本研究将提供 关于注意力缺陷多动症（ADHD）的信息，随着受试者从青春期成熟到年轻成人 生活。 这些科目将在六个领域进行评估：精神病理学、 认知神经心理功能、学校功能障碍、适应性 功能、治疗干预和心理社会逆境。 品种齐全 措施包含在每个领域的评估中。 分析方法 解决六个问题：精神疾病发病的不同年龄； 家庭内部和时间段之间的观察不独立； 治疗效果；整合多个信息提供者的信息； 混杂变量的影响；基线时样本的年龄范围很广。 研究人员将测试三个一般假设： 结果预测 基于基线 ADHD（或 ADHD 的兄弟）；结果预测基于 合并症；基于 DSM-IV 亚型的结果和合并症预测。