HEALthy Brain and Child Development Study at UAB and UA

UAB 和 UA 的健康大脑和儿童发展研究

基本信息

批准号：
10380426
负责人：
Ada Myriam Peralta-Carcelen
金额：
$ 114.01万
依托单位：
UNIVERSITY OF ALABAMA AT BIRMINGHAM
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-30 至 2026-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10380426
关键词：
Academic Medical Centers Address Adolescence Affect Alabama Alcohols Area Award Basic Science Behavioral Biological Birth Brain Brain imaging Center for Translational Science Activities Child Child Development Childhood Clinic Clinical Research Cognitive Collaborations Communities County Data Data Collection Databases Development Discipline of obstetrics Drug Exposure Electroencephalography Endocrine system Enrollment Environment Environmental Exposure Environmental Risk Factor Epigenetic Process Evaluation Exposure to General Population Genetic Goals Growth Gynecology Health Helping to End Addiction Long-term Home Individual Individual Differences Infant Infant Development International Longitudinal Studies Longitudinal cohort study Marijuana Maternal Health Maternal and Child Health Maternal-fetal medicine Medicaid Metabolic Minority Groups Mothers Multicenter Neonatal Research Network Multicenter Studies National Institute of Child Health and Human Development Neighborhood Health Center Neurodevelopmental Disability Neurosecretory Systems Nicotine Normal Range Opioid Outcome Parent-Child Relations Participant Perinatal Population Population Heterogeneity Pregnancy Pregnancy Trimesters Pregnant Women Prenatal care Protocols documentation Provider Recording of previous events Research Resources Rivers Rural Rural Community Rural Health Rural Minority Rural Population SARS-CoV-2 exposure Sampling Scientist Second Pregnancy Trimester Site Social Behavior Stress Structure Tobacco Toxic Environmental Substances Translational Research Ultrasonography United States National Institutes of Health Universities Weaning Well in self Woman addiction antenatal autism spectrum disorder behavioral health biobank biological systems clinical research site cohort design early experience early life exposure emotional behavior experience follow-up high risk illicit opioid immune function in utero indexing multimodal data neonatal exposure neurodevelopment neuroimaging opioid exposure prenatal prenatal exposure prescription opioid programs prospective recruit research study response sample collection socioeconomics substance use treatment program

项目摘要

Brain development during the early years goes through rapid change with vulnerable periods where a variety of environmental exposures can have a large and enduring impact in early neurodevelopment and long-term health outcomes. Experiences will permanently modify brain structure and function through epigenetic changes that contribute to individual differences, in addition to reciprocal interactions among brain plasticity and autonomic neuroendocrine, metabolic, and immune functions. Few studies have addressed how early brain development and trajectories are impacted by early experiences and potential biological interactions within a diverse population inclusive of rural and minority populations. The central goal of the HEAL Initiative: HEALthy Brain and Child Development study is to prospectively examine brain and behavioral development from birth through childhood with emphasis on the impact of in utero substance exposure on outcome. At the University of Alabama at Birmingham (UAB) and the University of Alabama (UA) we will enroll pregnant women during their second trimester and follow their infants with a comprehensive multimodal data longitudinal study. Strengths to UAB include the Comprehensive Addiction in Pregnancy Program (CAPP) that provides prenatal care and support to pregnant women with history of substance use. UAB OB supports several prenatal clinics within Jefferson and Blount County Departments of Health, neighborhood health centers, and the Complications clinic. UAB is actively enrolling participants for the HEAL Outcomes of Babies with Opioid exposure and the ACT NOW Weaning study. UAB is a site for the NICHD Maternal Fetal Medicine Network and the NICHD Neonatal Research Network for >25 years, with long-standing, well-established and highly productive collaborations with other centers. UA operates at the University Medical Center in Tuscaloosa that serves the majority of the Medicaid recipients in the region as well as rural clinics in surrounding counties, including those in the Alabama Black Belt. The UA team has expertise in neuroimaging, EEG, rural health, maternal health and child development. Therefore, there is demonstrated adequacy of clinical, research, administrative and facilities to accomplish this project. We clearly express our intent to participate in a cooperative manner with the other research sites, the HDCC, HCAC, the NIH Program Scientist and the NIH Program Official in all aspects of research in a manner consistent with the terms of the award. Specific Aims: 1. Determine typical neurodevelopmental trajectories and typical range of variability of brain development from birth through childhood in a diverse population. 2. Determine how early life exposure to opioids, other substances, and other adverse environmental circumstances affect these trajectories. 3. Determine how genetic influences interact with environmental factors to influence neurodevelopment. Design: 300 mother/child dyads (100 with and 200 without history of drug exposure) with complete longitudinal brain, behavioral and biological assessment in conjunction with other research sites within the HEAL Initiative.

早年的大脑发育经历了快速变化和脆弱时期，其中各种因素环境暴露会对早期神经发育和长期神经发育产生巨大而持久的影响健康结果。经验将通过表观遗传变化永久改变大脑结构和功能除了大脑可塑性和大脑可塑性之间的相互作用之外，还导致个体差异自主神经内分泌、代谢和免疫功能。很少有研究探讨早期大脑如何发展和轨迹受到早期经历和潜在生物相互作用的影响多样化的人口，包括农村人口和少数民族人口。 HEAL 计划的中心目标：健康大脑和儿童发展研究是前瞻性地检查从出生起的大脑和行为发展整个童年时期，重点关注子宫内物质暴露对结果的影响。在阿拉巴马大学伯明翰分校 (UAB) 和阿拉巴马大学 (UA)，我们将招收孕妇妊娠中期的妇女并通过全面的多模式纵向数据跟踪她们的婴儿学习。 UAB 的优势包括妊娠期综合成瘾计划 (CAPP)，该计划提供为有药物使用史的孕妇提供产前护理和支持。 UAB OB 支持多项产前服务杰斐逊县和布朗特县卫生部内的诊所、社区卫生中心以及并发症门诊。 UAB 正在积极招募阿片类药物婴儿治愈结果参与者暴露和立即行动断奶研究。 UAB 是 NICHD 母胎医学网络的网站， NICHD 新生儿研究网络已有超过 25 年的历史，历史悠久、完善且富有成效与其他中心的合作。 UA 在塔斯卡卢萨大学医疗中心运营，为该地区大多数医疗补助受益人以及周边县的农村诊所，包括那些在阿拉巴马州黑带。 UA 团队拥有神经影像、脑电图、农村健康、孕产妇健康和儿童发展。因此，临床、研究、行政和设施均已证明充足来完成这个项目。我们明确表达了与对方合作参与的意愿研究中心、HDCC、HCAC、NIH 项目科学家和 NIH 项目官员在各个方面以符合奖项条款的方式进行研究。具体目标： 1. 确定典型的神经发育轨迹和典型的大脑变异范围不同人群从出生到童年的发展。 2. 确定生命早期如何接触阿片类药物、其他物质和其他不利的环境条件都会影响这些轨迹。 3. 确定遗传影响如何与环境因素相互作用以影响神经发育。设计：300 名母子二人组（100 名有药物暴露史，200 名无药物暴露史），具有完整的纵向与 HEAL Initiative 内的其他研究机构联合进行大脑、行为和生物评估。