OUTCOME OF PRETERM SMALL FOR GESTATIONAL AGE ADOLESCENTS

胎龄青少年早产儿的结局

• 批准号: 2884922
• 负责人: Ada Myriam Peralta-Carcelen
• 金额: $ 11.04万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-01 至 2002-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2884922
• 关键词: academic achievement; adolescence (12-20); body height; body weight; bone development disorder; child physical development; clinical research; cognition; developmental neurobiology; female; functional ability; gestational age; human birth weight; human puberty; human subject; longitudinal human study; low birth weight infant human; middle childhood (6-11); outcomes research; photon absorptiometry; premature infant human; prenatal growth disorder; quality of life; socioenvironment; women's health

The candidate is a Pediatrician with an MPH in maternal and child health. She is an attending physician in clinics for follow-up of high-risk children and child development. She has begun scientific work and established relationships related to her special interests on understanding the impact of pregnancy-related and perinatal events on the long-term outcome for child growth and development. Her immediate goals are to develop a systematic program of research on the long-term outcomes of low birth weight infants, by increasing her knowledge of assessments of neurodevelopment of children and adolescents at risk, and by obtaining more training in statistical analysis of large databases and growth curve analysis. This knowledge will assist her to develop her ability to design and conduct multi-center clinical trials, to manage large databases and to design useful research outcome measurements for evaluating developmental outcomes in large populations. She describes a didactic curriculum and specific consultations to achieve this knowledge. Within the multidisciplinary infrastructure, existing at UAB she will work in particular with the Civitan International Research Center, a center specialized in development and outcome assessments of children. She will be working with several senior faculty experts in her area of research. The proposed project is a prospective longitudinal study that will assess the long-term outcomes of preterm children who participated in the Successive Small for Gestational Age (SGA) Study, an NICHD sponsored study, that recruited multiparous low-income pregnant women at risk for Intrauterine Growth Retardation (IUGR) from a single county. These women and their infants were followed antenatally, at birth and at 1 and 5 years of age. The overall hypothesis of this proposed study is that growth and development of preterm SGA adolescents will be impaired compared to preterm Appropriate for Gestational Age (AGA) children. Growth and developmental outcomes will correlate with prenatal and perinatal variables after controlling for postnatal variables.The study will include 99 preterm (<37 weeks gestation) SGA and 121 preterm AGA children who were born between 1986 and 1988. These children will be 11 to 13 years at the time of the assessments. All participants will be assessed for growth using anthropometric measures, development of skeletal mass, body composition (dual energy X-Ray absorptiometry and bone age), and sexual maturation. Developmental assessment will include assessing academic achievement, cognitive scores, assessment of learning disabilities, behavioral and functional outcome instruments. This study should provide important information to understand the longterm outcomes for children who were born after IUGR and its relationship with prenatal and perinatal events.

候选人是一名儿科医生，拥有妇幼健康领域的公共卫生硕士学位。她是诊所的主治医生，负责跟踪高危儿童和儿童发育。她已经开始了科学研究工作，并建立了与她的特殊兴趣相关的关系，即了解怀孕相关和围产期事件对儿童生长和发育的长期结果的影响。她的近期目标是通过增加对高危儿童和青少年神经发育评估的了解，并获得更多大型数据库统计分析方面的培训，制定一个关于低出生体重婴儿长期结果的系统研究计划。生长曲线分析。这些知识将帮助她发展设计和进行多中心临床试验、管理大型数据库以及设计有用的研究结果测量以评估大量人群的发育结果的能力。她描述了获取这些知识的教学课程和具体咨询。在阿拉巴马大学现有的多学科基础设施内，她将特别与奇维坦国际研究中心合作，该中心专门从事儿童发展和成果评估。她将与她研究领域的几位资深教授专家合作。拟议的项目是一项前瞻性纵向研究，将评估参加连续小于胎龄 (SGA) 研究的早产儿的长期结果，该研究是 NICHD 资助的一项研究，招募了有宫内妊娠风险的多产低收入孕妇。来自单个县的生长迟缓 (IUGR)。这些妇女及其婴儿在产前、出生时以及 1 岁和 5 岁时都接受了随访。这项研究的总体假设是，与早产适龄 (AGA) 儿童相比，早产 SGA 青少年的生长和发育会受到损害。控制产后变量后，生长和发育结果将与产前和围产期变量相关。该研究将包括 1986 年至 1988 年间出生的 99 名早产（妊娠 <37 周）SGA 儿童和 121 名早产 AGA 儿童。这些儿童年龄为 11 至 13 岁评估时的年数。将使用人体测量指标对所有参与者的生长、骨骼质量发育、身体成分（双能 X 射线吸收测定法和骨龄）和性成熟进行评估。发展评估将包括评估学业成绩、认知分数、学习障碍评估、行为和功能结果工具。这项研究应该提供重要信息，以了解 IUGR 后出生的儿童的长期结局及其与产前和围产期事件的关系。