OUTCOME OF PRETERM SMALL FOR GESTATIONAL AGE ADOLESCENTS

胎龄青少年早产儿的结局

• 批准号: 2884922
• 负责人: Ada Myriam Peralta-Carcelen
• 金额: $ 11.04万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-01 至 2002-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2884922
• 关键词: academic achievement; adolescence (12-20); body height; body weight; bone development disorder; child physical development; clinical research; cognition; developmental neurobiology; female; functional ability; gestational age; human birth weight; human puberty; human subject; longitudinal human study; low birth weight infant human; middle childhood (6-11); outcomes research; photon absorptiometry; premature infant human; prenatal growth disorder; quality of life; socioenvironment; women's health

The candidate is a Pediatrician with an MPH in maternal and child health. She is an attending physician in clinics for follow-up of high-risk children and child development. She has begun scientific work and established relationships related to her special interests on understanding the impact of pregnancy-related and perinatal events on the long-term outcome for child growth and development. Her immediate goals are to develop a systematic program of research on the long-term outcomes of low birth weight infants, by increasing her knowledge of assessments of neurodevelopment of children and adolescents at risk, and by obtaining more training in statistical analysis of large databases and growth curve analysis. This knowledge will assist her to develop her ability to design and conduct multi-center clinical trials, to manage large databases and to design useful research outcome measurements for evaluating developmental outcomes in large populations. She describes a didactic curriculum and specific consultations to achieve this knowledge. Within the multidisciplinary infrastructure, existing at UAB she will work in particular with the Civitan International Research Center, a center specialized in development and outcome assessments of children. She will be working with several senior faculty experts in her area of research. The proposed project is a prospective longitudinal study that will assess the long-term outcomes of preterm children who participated in the Successive Small for Gestational Age (SGA) Study, an NICHD sponsored study, that recruited multiparous low-income pregnant women at risk for Intrauterine Growth Retardation (IUGR) from a single county. These women and their infants were followed antenatally, at birth and at 1 and 5 years of age. The overall hypothesis of this proposed study is that growth and development of preterm SGA adolescents will be impaired compared to preterm Appropriate for Gestational Age (AGA) children. Growth and developmental outcomes will correlate with prenatal and perinatal variables after controlling for postnatal variables.The study will include 99 preterm (<37 weeks gestation) SGA and 121 preterm AGA children who were born between 1986 and 1988. These children will be 11 to 13 years at the time of the assessments. All participants will be assessed for growth using anthropometric measures, development of skeletal mass, body composition (dual energy X-Ray absorptiometry and bone age), and sexual maturation. Developmental assessment will include assessing academic achievement, cognitive scores, assessment of learning disabilities, behavioral and functional outcome instruments. This study should provide important information to understand the longterm outcomes for children who were born after IUGR and its relationship with prenatal and perinatal events.

候选人是一名儿科医生，在产妇和儿童健康方面具有MPH。她是诊所的主体医师，以随访高危儿童和儿童发育。她已经开始科学工作，并建立了与她在理解与怀孕有关的和围产期事件对长期结果对儿童成长和成长的长期结果的影响方面的特殊兴趣有关的关系。她的近期目标是通过增加对处于危险的儿童和青少年神经发育的评估的了解，并通过对大型数据库和大型数据库和成长曲线分析的统计分析进行更多培训来制定有关低出生体重婴儿长期结局的系统研究计划。这些知识将有助于她发展设计和进行多中心临床试验，管理大型数据库和设计有用的研究结果测量的能力，以评估大量人群的发展成果。她描述了一个教学课程和特定的咨询，以实现这一知识。在多学科的基础设施中，在UAB上，她将特别与Civitan International Research Center合作，这是一个专门研究儿童发展和成果评估的中心。她将与研究领域的几位高级教师专家合作。拟议的项目是一项前瞻性纵向研究，它将评估参加连续的NICHD赞助研究的胎龄（SGA）研究的早产儿（SGA）研究的长期结局，该研究是NICHD赞助的一项研究，该研究从一个单身县招募了多个低收入孕妇，招募了多个低收入的孕妇。这些妇女及其婴儿在出生时，1岁和5岁时就受到了追踪。这项拟议的研究的总体假设是，与适合胎龄（AGA）儿童的早产相比，早产SGA青少年的生长和发展将受到损害。控制产后变量后，生长和发育结果将与产前和围产期变量相关。该研究将包括99例早产（<37周妊娠）SGA和121名早产AGA儿童，他们出生于1986年至1988年之间。评估时这些孩子将为11至13岁。所有参与者将使用人体测量指标，骨骼质量的发展，身体组成（双能X射线吸收仪和骨龄年龄）以及性成熟来评估所有参与者。发展评估将包括评估学术成就，认知得分，学习障碍评估，行为和功能结果工具。这项研究应提供重要的信息，以了解IUGR以后出生的儿童的长期结果及其与产前和围产期事件的关系。