Mapping and Serotonergic Regulation of Multiple BDNF Transcript Isoforms in Mice

小鼠多种 BDNF 转录亚型的定位和血清素调节

基本信息

批准号：
7258654
负责人：
ANNE MILASINCIC ANDREWS
金额：
$ 6.66万
依托单位：
PENNSYLVANIA STATE UNIVERSITY, THE
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-05-09 至 2009-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7258654
关键词：
Accounting Address Adult Alzheimer&apos s Disease Antidepressive Agents Anxiety Anxiety Disorders Atrophic Behavior Behavioral Brain Brain Diseases Brain Stem Brain region Brain-Derived Neurotrophic Factor Chronic Chronic stress Code Complex Degenerative Disorder Development Disruption Drug abuse Environmental Risk Factor Epigenetic Process Exons Future Genbank Gene Expression Genes Genetic Transcription Genetically Engineered Mouse Hippocampus (Brain)Human Individual Investigation Learning Maps Mediating Memory Mental Depression Messenger RNA Molecular Mus Neurons Numbers Pattern Personality Traits Phenotype Play Population Predisposition Protein Isoforms Proteins Quantitative Reverse Transcriptase PCR RNA Splicing Range Rattus Regulation Role Schizophrenia Seizures Selective Serotonin Reuptake Inhibitor Serotonin Signal Pathway Signal Transduction Stress Structure Time Transcript Transcriptional Regulation Tricyclic Antidepressive Agents Variant cell type clinically relevant conditioned fear design frontal lobe mood regulation mouse model neurogenesis novel therapeutics promoter response reuptake serotonergic regulation serotonin receptor serotonin transporter transcription factor

项目摘要

DESCRIPTION (provided by applicant): Understanding the modulation of individual BDNF mRNA splice variants by two clinically relevant forms of reduced serotonin reuptake will facilitate our understanding of the role of BDNF in the regulation of mood and anxiety-related behavior. It will also assist us in addressing long-range questions such as why BDNF is subject to complex transcriptional regulation and how this is reflected in different BDNF protein levels in specific subregions or neuronal subtypes in psychiatric and degenerative brain disorders? Ultimately, we anticipate that having the capability to selectively modulate BDNF at the level of transcription in different cell types and brain regions will be a powerful avenue for the future development of novel therapeutics for the treatment of depression, anxiety disorders and Alzheimer's disease.

描述（由申请人提供）：通过两种临床相关形式减少5-羟色胺再摄取形式对单个BDNF mRNA剪接变体的调节将有助于我们理解BDNF在调节情绪和焦虑相关行为中的作用。它还将帮助我们解决远距离问题，例如为什么BDNF受到复杂的转录调节，以及在特定子区域的不同BDNF蛋白水平或精神病和退化性脑疾病中的神经元亚型中如何反映出来？最终，我们预计有能力在不同细胞类型和大脑区域的转录水平上有选择性调节BDNF将是对抑郁症，焦虑症和阿尔茨海默氏病治疗新型疗法的未来发展的强大途径。