An Animal Biosafety Level 3 Laboratory for Stony Brook University

石溪大学动物生物安全三级实验室

基本信息

批准号：
7872073
负责人：
SAMUEL L. STANLEY
金额：
$ 1417.96万
依托单位：
STATE UNIVERSITY NEW YORK STONY BROOK
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-03-25 至 2015-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7872073
关键词：
Accreditation American Animal Experimentation Animal Housing Animals Arthropods Biological Biomedical Research Categories Centers for Disease Control and Prevention (U.S.)Communicable Diseases Equipment Extramural Activities Facility Accesses Facility Design and Construction Francisella tularensis Funding Funding Opportunities Health Sciences Human Image Infectious Diseases Research Institution Investigation Laboratories Laboratory Animals Laws Medical Mycobacterium tuberculosis Occupations Office of Administrative Management Recovery Research Facilities Construction Grants Research Personnel Research Support Science Security Solid Structure Technology United States National Institutes of Health United States Public Health Service Universities Virulence Work Yersinia pestis animal care animal facility animal resource biosafety level 3 facility cost design improved in vivo meetings operation pathogen research facility square foot

项目摘要

DESCRIPTION (provided by applicant): This application seeks funds for the construction of the first Animal Biosafety Level 3 Laboratory (A-BSL-3) in the Division of Laboratory Animal Research at the Health Sciences Center at Stony Brook University. The A- BSL-3 will have three suites for work with small laboratory animals, an insectary, and an imaging suite with an adjacent room for work with large laboratory animals. The planned structure will be a 16,140 ft sq. strict BSL-3 controlled-access facility for research involving laboratory animals and studies with the Select Agents Francisella tularensis and Yersinia pestis (both CDC Category A); Mycobacterium tuberculosis; pathogens of unknown in vivo virulence; arthropods infected with human and veterinary pathogens; or any investigations using laboratory animals that may require stringent laboratory security. The imaging suite is designed to allow operation under A-BSL-3 or A-BSL-2 conditions, which will permit access to its equipment by all University investigators in the biological and medical sciences and to investigators at the adjacent institutions of Brookhaven National Laboratory and Cold Spring Harbor Laboratory. The A-BSL-3 will be equipped with the following fixed equipment: Class II Biosafety Cabinets, a pass-thru cold room, fume hoods, cage and rack washers, ventilated animal housing equipment, and a pass-through autoclave. The A-BSL-3 facility will serve an initial group of investigators with solid funding in infectious disease research through the National Institutes of Health, and a secondary group of investigators, also funded by the NIH. The A-BSL-3 facility will further enhance synergy among the researchers involved in the infectious disease enterprise at Stony Brook University and adjacent institutions. At completion, the A-BSL-3 will meet all the requirements of federal and state laws, and the standards recommended by the Association for the Assessment and Accreditation of Laboratory Animal Care. An administrative management team consisting of a PI (Dr. Samuel L. Stanley), an Executive Committee, the Director and Assistant Director of Facilities Design and Construction, a Scientific Users Committee, and the Director of the Division of Laboratory Animal Resources will oversee the construction and use of the facility. The A-BSL-3 at Stony Brook University will fulfill the objectives of the American Recovery and Reinvestment Act of 2009, and the Funding Opportunity Announcement Recovery Act Limited Competition: Extramural Research Facilities Improvement Program (C06) as it will: enhance the conduct of Public Health Service-supported biomedical research by supporting the costs of improving animal facilities to meet the biomedical research needs of an institution; be built to incorporate green/sustainable technologies and design approaches; and create and maintain American jobs.

描述（由申请人提供）：本申请为石溪大学健康科学中心实验动物研究部建设第一个动物生物安全三级实验室（A-BSL-3）寻求资金。 A-BSL-3 将拥有三个用于小型实验动物工作的套房、一个昆虫室和一个成像套房，相邻的房间用于大型实验动物的工作。规划的结构将是一个 16,140 平方英尺的严格 BSL-3 受控访问设施，用于涉及实验动物的研究以及土拉弗朗西斯氏菌和鼠疫耶尔森氏菌（均为 CDC A 类）特选病原体的研究；结核分枝杆菌；体内毒力未知的病原体；感染人类和兽医病原体的节肢动物；或任何可能需要严格实验室安全的使用实验动物的调查。该成像套件旨在允许在 A-BSL-3 或 A-BSL-2 条件下运行，这将允许生物和医学领域的所有大学研究人员以及布鲁克海文国家实验室邻近机构的研究人员使用其设备和冷泉港实验室。 A-BSL-3 将配备以下固定设备：II 级生物安全柜、直通式冷室、通风柜、笼架清洗机、通风动物饲养设备和直通式高压灭菌器。 A-BSL-3 设施将为第一批研究人员提供服务，这些研究人员通过美国国立卫生研究院获得充足的传染病研究资金，并为第二批研究人员提供服务，第二批研究人员也由 NIH 资助。 A-BSL-3 设施将进一步增强石溪大学及邻近机构从事传染病研究的研究人员之间的协同作用。完成后，A-BSL-3 将满足联邦和州法律的所有要求以及实验动物护理评估和认证协会推荐的标准。由 PI（Samuel L. Stanley 博士）、执行委员会、设施设计和施工主任和助理主任、科学用户委员会以及实验动物资源司司长组成的行政管理团队将监督设施的建设和使用。石溪大学的 A-BSL-3 将实现《2009 年美国复苏和再投资法案》以及《资助机会公告复苏法案有限竞争：校外研究设施改进计划》(C06) 的目标，因为它将：公共卫生服务通过支持改善动物设施的成本来支持生物医学研究，以满足机构的生物医学研究需求；融入绿色/可持续技术和设计方法；创造并维持美国就业机会。