Malaria Research Training in South India

印度南部的疟疾研究培训

• 批准号: 7933399
• 负责人: CHANNE D GOWDA
• 金额: $ 13.98万
• 依托单位: PENNSYLVANIA STATE UNIV HERSHEY MED CTR
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-01 至 2016-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7933399
• 关键词: 6H,8H-3,4-dihydropyrimido(4,5-c)(1,2)oxazin-7-one; Affect; Applications Grants; Benign; Biology; Cities; Clinical; Doctor of Philosophy; Drug resistance; Educational workshop; Fostering; Goals; Health; India; Infection; Knowledge; Laboratory Research; Malaria; Measures; Parasites; Pregnant Women; Recruitment Activity; Research; Research Personnel; Research Project Grants; Research Training; Resources; Students; Training; Training Programs; Vivax Malaria; Work; cytokine; epidemiology study; experience; field study; programs; public health relevance; response; symposium

DESCRIPTION (provided by applicant): Although P. vivax infection has been commonly considered to be benign, in recent years it has been associated with severe malaria with significant fatalities. Like in other parts of the world, P. vivax malaria infection predominates in India, including South India. Despite the enormity of P. vivax associated malaria health burden, research efforts to understand the pathophysiological and immunological basis for P. vivax severe malaria have been meager. Very little or no malaria research, especially on P. vivax, is being undertaken in South India, particularly in the Karnataka State. This is due to lack of resources and scarcity of skilled and experienced malaria investigators. The overall goal of this grant application is to train young and meritorious PhD students from India on P. vivax malaria in Mangalore city of Southwestern Karnataka. The training will be given by a group of expert Indian and US investigators recruited to this program. Four PhD students will be trained on P. vivax malaria so that they become expert investigators and are able to take up independent studies on aspects of malaria that are relevant to the study region. The training will be imparted through field studies, laboratory research work, and by organizing symposia and workshops. Specific research aspects for training include: (I) to study the epidemiology of malaria infection and parasite drug resistance, (ii) to gain information on the clinical presentations of P. vivax malaria and cytokine responses, and (iii) to understand the impact of P. vivax infection in pregnant women. The long-term goals are to support and foster research projects taken up by trainees as independent investigators, conducting research on malaria in the Southwestern region of India. Public Health Relevance: P. vivax malaria that was so far considered to be benign is becoming increasingly fatal in many parts of the world, including India and as such, vivax malaria is a global concern. Appropriate control measures and in- depth understanding of drug resistance and parasite biology in various affected regions are required for the global malaria control. This training program will help advance our knowledge on P. vivax malaria in Southwestern India, the region in which so far no significant research efforts have been made despite the wide spread infection and health burden.

描述（由申请人提供）：尽管间日疟原虫感染通常被认为是良性的，但近年来它与严重疟疾相关，导致大量死亡。与世界其他地区一样，间日疟原虫疟疾感染在印度（包括印度南部）占主导地位。尽管间日疟原虫相关的疟疾健康负担巨大，但了解间日疟原虫严重疟疾的病理生理学和免疫学基础的研究工作却很少。印度南部，特别是卡纳塔克邦，很少或根本没有进行疟疾研究，特别是关于间日疟的研究。这是由于缺乏资源以及缺乏熟练且经验丰富的疟疾调查人员。这笔赠款申请的总体目标是在卡纳塔克邦西南部门格洛尔市培训来自印度的年轻且优秀的博士生，研究间日疟原虫。培训将由该计划招募的一组印度和美国专家调查员进行。四名博士生将接受关于间日疟原虫疟疾的培训，以便他们成为专家研究人员，并能够对与研究区域相关的疟疾方面进行独立研究。培训将通过实地研究、实验室研究工作以及组织研讨会和讲习班的方式进行。 培训的具体研究方面包括：(I) 研究疟疾感染和寄生虫耐药性的流行病学，(ii) 获取有关间日疟疾临床表现和细胞因子反应的信息，以及 (iii) 了解疟疾感染的影响孕妇间日疟原虫感染。长期目标是支持和促进受训人员作为独立调查员开展的研究项目，在印度西南部地区开展疟疾研究。 公共卫生相关性：迄今为止被认为是良性的间日疟疾在世界许多地区（包括印度）变得越来越致命，因此，间日疟疾是全球关注的问题。全球疟疾控制需要采取适当的控制措施并深入了解各个受影响地区的耐药性和寄生虫生物学。该培训计划将有助于增进我们对印度西南部间日疟原虫疟疾的了解，尽管该地区的感染广泛传播并造成健康负担，但迄今为止尚未开展重大研究工作。