Overall Evaluation/Go, Vay Liang

总体评价/Go, Vay Liang

• 批准号: 7394064
• 负责人: Vay Liang W Go
• 金额: $ 68.45万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-12-01 至 2012-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7394064
• 关键词: Alternative Medicine; Animal Model; Biological; Biometry; Botanicals; Cell physiology; Data; Disease; Evaluation; Flavonoids; Goals; Healthcare Systems; Inflammatory; Interdisciplinary Study; Investigation; Lipids; Los Angeles; Malignant neoplasm of pancreas; Measures; Medical center; Metabolic; Metabolism; Molecular Biology; National Center for Complementary and Alternative Medicine; Pancreas; Pancreatic Diseases; Phenotype; Phytochemical; Prevention; Prevention therapy; Process; Research; Research Institute; Research Personnel; Research Project Grants; Resources; Role; Technology; Tracer; angiogenesis; base; carcinogenesis; design; dietary supplements; experience; metabolomics; polyphenol; programs; response; tool

The UCLA Center for Excellence in Pancreatic Diseases constitutes a highly collaborative, multidisciplinary research program designed to make a significant impact on the investigation of complimentary and alternative medicine in the prevention and therapy of pancreatic diseases. Biological mechanisms of action of botanicals and dietary supplements on pancreatic diseases and characterization of metabolic phenotypes in response to specific phytonutrients can form the rationale for biologically-based practices in the prevention and treatment of pancreatic diseases. Our Center includes expertise from the UCLA campus, LA BioMed Research Institute at Harbor-UCLA Medical Center, and VA Greater Los Angeles Healthcare System-West Los Angeles (VAGLAHS-WLA). The Center is led by experienced pancreatic disease researchers who have organized investigative teams to develop highly interactive and synergistic research programs. Our goal is to study the phytonutrient mechanism of action in both inflammatory and proliferative diseases of the pancreas in which we will use molecular biology and metabolomic technology to investigate altered cellular function. Characterization of metabolic phenotypes in response to specific phytonutrients can be measured by tracer metabolomics. These scientific programs will investigate the mechanisms of action of phytonutrients in both inflammatory and proliferative diseases of the pancreas utilizing both molecular biology tools and metabolomics technology. The projects will focus on: Project 1 - the effects of phytochemicals and metabolism in pancreatic diseases, Project 2 - role of polyphenols in regulating lipid inflammatory process in pancreatic cancer, and Project 3 - the effects of flavonoids on pancreatic carcinogenesis and angiogenesis. The projects will utilize our shared core resources including the Administrative Core, Animal Model Core, Phytonutrient Core, and Metabolomics Core. The Administrative Core includes a Biostatistics Sub-Core to provide biostatistical support to all the research projects and core functions, as well as the management of research and shared data functions of the Center. We also plan to select an External Advisory Board comprised of nationally and internationally recognized translational pancreatic disease researchers. The UCLA Center for Excellence is designed for maximum integration and synergy of research of key investigators who have been collaborating over the years so that the Center can be focused on the most promising investigations with the greatest NCCAM translational potential.

加州大学洛杉矶分校胰腺疾病卓越中心是一个高度协作、多学科的中心 研究计划旨在对免费和免费的调查产生重大影响 预防和治疗胰腺疾病的替代医学。生物作用机制 植物药和膳食补充剂对胰腺疾病的影响以及代谢表型的表征 针对特定植物营养素的反应可以形成基于生物学的预防实践的基本原理 以及胰腺疾病的治疗。我们的中心拥有来自 UCLA 校园、LA BioMed 的专业知识 港口研究所 - 加州大学洛杉矶分校医疗中心和 VA 大洛杉矶医疗系统 - 西部 洛杉矶 (VAGLAHS-WLA)。该中心由经验丰富的胰腺疾病研究人员领导，他们 组织调查小组制定高度互动和协同的研究计划。我们的目标是 研究植物营养素在炎症和增殖性疾病中的作用机制 胰腺，我们将使用分子生物学和代谢组学技术来研究改变的细胞 功能。可以测量对特定植物营养素的代谢表型特征 通过示踪代谢组学。这些科学计划将研究其作用机制 植物营养素在胰腺炎症和增殖性疾病中利用分子 生物学工具和代谢组学技术。这些项目将重点关注： 项目 1 - 的影响 胰腺疾病中的植物化学物质和代谢，项目 2 - 多酚在调节脂质中的作用 胰腺癌的炎症过程，以及项目 3 - 类黄酮对胰腺的影响 致癌作用和血管生成。这些项目将利用我们共享的核心资源，包括 管理核心、动物模型核心、植物营养素核心和代谢组学核心。行政部门 核心包括生物统计子核心，为所有研究项目和核心提供生物统计支持 职能，以及中心研究和共享数据职能的管理。我们还计划 选择一个由国内和国际公认的翻译专家组成的外部顾问委员会 胰腺疾病研究人员。加州大学洛杉矶分校卓越中心旨在实现最大程度的整合和 多年来一直合作的主要研究人员的研究协同作用，以便该中心能够 专注于最具 NCCAM 转化潜力的最有前景的研究。