UCLA Center for Excellence in Pancreatic Diseases

加州大学洛杉矶分校胰腺疾病卓越中心

• 批准号: 7914048
• 负责人: Vay Liang W Go
• 金额: $ 110.45万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-30 至 2012-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7914048
• 关键词: UCLA; Center; Excellence; Pancreatic; Diseases

DESCRIPTION (provided by applicant): The UCLA Center for Excellence in Pancreatic Diseases constitutes a highly collaborative, multidisciplinary research program designed to make a significant impact on the investigation of complimentary and alternative medicine in the prevention and therapy of pancreatic diseases. Biological mechanisms of action of botanicals and dietary supplements on pancreatic diseases and characterization of metabolic phenotypes in response to specific phytonutrients can form the rationale for biologically-based practices in the prevention and treatment of pancreatic diseases. Our Center includes expertise from the UCLA campus, LA BioMed Research Institute at Harbor-UCLA Medical Center, and VA Greater Los Angeles Healthcare System-West Los Angeles (VAGLAHS-WLA). The Center is led by experienced pancreatic disease researchers who have organized investigative teams to develop highly interactive and synergistic research programs. Our goal is to study the phytonutrient mechanism of action in both inflammatory and proliferative diseases of the pancreas in which we will use molecular biology and metabolomic technology to investigate altered cellular function. Characterization of metabolic phenotypes in response to specific phytonutrients can be measured by tracer metabolomics. These scientific programs will investigate the mechanisms of action of phytonutrients in both inflammatory and proliferative diseases of the pancreas utilizing both molecular biology tools and metabolomics technology. The projects will focus on: Project 1 - the effects of phytochemicals and metabolism in pancreatic diseases, Project 2 - role of polyphenols in regulating lipid inflammatory process in pancreatic cancer, and Project 3 - the effects of flavonoids on pancreatic carcinogenesis and angiogenesis. The projects will utilize our shared core resources including the Administrative Core, Animal Model Core, Phytonutrient Core, and Metabolomics Core. The Administrative Core includes a Biostatistics Sub-Core to provide biostatistical support to all the research projects and core functions, as well as the management of research and shared data functions of the Center. We also plan to select an External Advisory Board comprised of nationally and internationally recognized translational pancreatic disease researchers. The UCLA Center for Excellence is designed for maximum integration and synergy of research of key investigators who have been collaborating over the years so that the Center can be focused on the most promising investigations with the greatest NCCAM translational potential.

描述（由申请人提供）：加州大学洛杉矶分校胰腺疾病卓越中心构成了一个高度协作的多学科研究项目，旨在对预防和治疗胰腺疾病的补充和替代医学的研究产生重大影响。植物药和膳食补充剂对胰腺疾病的生物学作用机制以及对特定植物营养素的代谢表型特征可以构成预防和治疗胰腺疾病的生物学实践的基本原理。我们的中心包括来自 UCLA 校区、Harbor-UCLA 医疗中心洛杉矶生物医学研究所以及 VA 大洛杉矶医疗系统 - 西洛杉矶 (VAGLAHS-WLA) 的专业知识。该中心由经验丰富的胰腺疾病研究人员领导，他们 组织调查小组制定高度互动和协同的研究计划。我们的目标是研究植物营养素在胰腺炎症和增殖性疾病中的作用机制，其中我们将使用分子生物学和代谢组学技术来研究改变的细胞 功能。可以通过示踪代谢组学来测量对特定植物营养素的代谢表型的表征。这些科学计划将利用分子生物学工具和代谢组学技术研究植物营养素在胰腺炎症和增殖性疾病中的作用机制。这些项目将重点关注： 项目 1 - 的影响 胰腺疾病中的植物化学物质和代谢，项目2 - 多酚在调节胰腺癌脂质炎症过程中的作用，以及项目3 - 黄酮类化合物对胰腺癌发生和血管生成的影响。这些项目将利用我们共享的核心资源，包括管理核心、动物模型核心、植物营养素核心和代谢组学核心。行政部门 核心包括生物统计子核心，为所有研究项目和核心职能以及中心的研究管理和共享数据职能提供生物统计支持。我们还计划选择一个由国内和国际公认的翻译专家组成的外部顾问委员会 胰腺疾病研究人员。加州大学洛杉矶分校卓越中心旨在最大程度地整合和协同多年来一直合作的主要研究人员的研究，以便该中心能够专注于最具 NCCAM 转化潜力的最有前途的研究。