Electrophysiological Correlates of Human Memory

人类记忆的电生理相关性

• 批准号: 6941019
• 负责人: PER Benjamin SEDERBERG
• 金额: $ 3.97万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-14 至 2006-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6941019
• 关键词: behavioral /social science research tag; bioimaging /biomedical imaging; brain electrical activity; brain mapping; clinical research; cues; electroencephalography; electrophysiology; hippocampus; human subject; learning; memory; molecular psychobiology; neocortex; neural information processing; predoctoral investigator; semantics

DESCRIPTION (provided by applicant): The proposed research seeks to illuminate the mechanisms of human learning and memory and, in particular, the role of brain oscillations in this vital human capacity. While it has recently been shown that certain brain oscillations increase during learning and memory tasks (an oscillatory subsequent memory effect, or SME), the exact nature of their involvement in memory function remains unknown. In the proposed studies brain waves will be recorded from patients undergoing surgical/invasive monitoring as part of the clinical treatment of medically refractory epilepsy. By performing cognitive tasks that pose no health risks whatsoever, these patients can provide exquisite data on the involvement of brain waves in memory formation. The proposed research aims to determine: (1) the relative roles of oscillations in hippocampus and neocortex in supporting memory formation, (2) the relation of the phase of oscillatory activity and the cognitive processes underlying memory formation, (3) the relation between the oscillatory SME and the traditionally studied event related potential SMEs, and (4), the roles of temporal and semantic information in producing SMEs in free recall.

描述（由申请人提供）：拟议的研究旨在阐明人类学习和记忆的机制，特别是大脑振荡在人类这一重要能力中的作用。 虽然最近的研究表明，某些大脑振荡在学习和记忆任务期间会增加（振荡随后记忆效应，或 SME），但它们参与记忆功能的确切性质仍然未知。 在拟议的研究中，将记录接受手术/侵入​​性监测的患者的脑电波，作为医学难治性癫痫临床治疗的一部分。 通过执行不构成任何健康风险的认知任务，这些患者可以提供关于脑电波参与记忆形成的精确数据。 拟议的研究旨在确定：（1）海马体和新皮质的振荡在支持记忆形成中的相对作用，（2）振荡活动的阶段与记忆形成背后的认知过程之间的关系，（3）振荡 SME 和传统研究的事件相关的潜在 SME，以及（4）时间和语义信息在自由回忆中产生 SME 中的作用。