Environmentally Responsive Nano0pores

环境响应型纳米孔

• 批准号: 7194177
• 负责人: ILYA ZHAROV
• 金额: $ 17.72万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-03-01 至 2009-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7194177
• 关键词: Environmentally; Responsive; Nano0pores

We propose to develop artificial membranes containing nanoscale pores whose mechanical, electrical, and chemical properties are controlled at a nanoscale with organic molecules. The pores will be fabricated in 30-50 nm silicon nitride membranes, and as an integral component of Pt/glass nanopore electrodes. The goal of the proposed work is to covalently modify the inner walls of 5-50 nm wide nanopores with organic molecules whose size and shape are sensitive to external stimuli, such as pH, solvent polarity, pX (where X is an ion or a small molecule), external electric field, light, etc., thus producing responsive nanopores. Specific aims of the project are: (1) to develop the preparation of the nanopores in silicon nitride and in glass to the specified size; (2) to design the molecules for the responsive nanopores, and to optimize the chemistry needed for their attachment to the nanopore walls; (3) to study the stimulus-response behavior of the attached molecules and their interactions within the confines of the nanopores; and (4) to study the transport dynamics within the resulting responsive nanopores. The pores have long-range applications in stochastic biosensor devices, in separations investigations of biomolecules, and in controlled drug release devices. The proposed work is a highly innovative, design-driven effort that will lead to the creation and use of nanoscale devices with a host of biological and medical applications. This effort brings together such disciplines as organic synthesis, surface chemistry, analytical chemistry, material science, and electrical engineering.

我们建议开发含有纳米级孔的人造膜，其机械、电学和化学性质由有机分子在纳米级控制。这些孔将在 30-50 nm 氮化硅膜中制造，并作为 Pt/玻璃纳米孔电极的组成部分。这项工作的目标是用有机分子共价修饰 5-50 nm 宽的纳米孔的内壁，这些有机分子的大小和形状对外部刺激敏感，例如 pH、溶剂极性、pX（其中 X 是离子或小分子）分子）、外部电场、光等，从而产生响应性纳米孔。该项目的具体目标是：（1）开发氮化硅和玻璃中指定尺寸的纳米孔的制备方法； (2) 设计响应纳米孔的分子，并优化 它们附着到纳米孔壁所需的化学物质； (3) 研究附着分子的刺激响应行为及其在纳米孔范围内的相互作用； (4) 研究由此产生的响应性纳米孔内的传输动力学。这些孔在随机生物传感器装置、生物分子的分离研究和受控药物释放装置中具有广泛的应用。 拟议的工作是一项高度创新、设计驱动的工作，将导致纳米级设备的创建和使用，并具有许多生物和医学应用。这项工作汇集了有机合成、表面化学、分析化学、材料科学和电气工程等学科。