Environmentally Responsive Nano0pores

环境响应型纳米孔

• 批准号: 6942489
• 负责人: ILYA ZHAROV
• 金额: $ 18.69万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-03-01 至 2008-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6942489
• 关键词: acidity /alkalinity; artificial membranes; atomic force microscopy; biological transport; biomaterial development /preparation; biomaterial evaluation; biomaterial interface interaction; electric field; glass; ions; lighting; molecular polarity; nanotechnology; nitrites; scanning electron microscopy; silicon; small molecule; stimulus /response; transmission electron microscopy

We propose to develop artificial membranes containing nanoscale pores whose mechanical, electrical, and chemical properties are controlled at a nanoscale with organic molecules. The pores will be fabricated in 30-50 nm silicon nitride membranes, and as an integral component of Pt/glass nanopore electrodes. The goal of the proposed work is to covalently modify the inner walls of 5-50 nm wide nanopores with organic molecules whose size and shape are sensitive to external stimuli, such as pH, solvent polarity, pX (where X is an ion or a small molecule), external electric field, light, etc., thus producing responsive nanopores. Specific aims of the project are: (1) to develop the preparation of the nanopores in silicon nitride and in glass to the specified size; (2) to design the molecules for the responsive nanopores, and to optimize the chemistry needed for their attachment to the nanopore walls; (3) to study the stimulus-response behavior of the attached molecules and their interactions within the confines of the nanopores; and (4) to study the transport dynamics within the resulting responsive nanopores. The pores have long-range applications in stochastic biosensor devices, in separations investigations of biomolecules, and in controlled drug release devices. The proposed work is a highly innovative, design-driven effort that will lead to the creation and use of nanoscale devices with a host of biological and medical applications. This effort brings together such disciplines as organic synthesis, surface chemistry, analytical chemistry, material science, and electrical engineering.

我们建议开发含有纳米级孔的人造膜，其机械，电和化学性质在带有有机分子的纳米级受到控制。这些孔将在30-50 nm的氮化膜中制造，并作为PT/玻璃纳米孔电极的组成部分。提议的工作的目的是共价修改5-50 nm宽的纳米孔的内壁，其大小和形状对外部刺激敏感，例如pH，溶剂极性，px（其中x是一个离子或小分子），外部电场，光线，光线等，因此产生了响应量的nanopores。该项目的具体目的是：（1）开发氮化硅和玻璃中纳米孔的制备； （2）设计响应纳米孔的分子，并优化 它们附着在纳米孔壁上所需的化学反应； （3）研究附着分子的刺激反应行为及其在纳米孔范围内的相互作用； （4）研究产生的响应纳米孔内的运输动力学。这些孔在随机生物传感器设备，生物分子的分离研究以及受控药物释放设备中具有长距离应用。 拟议的工作是一项高度创新的，以设计为驱动的工作，它将导致与许多生物学和医疗应用的纳米级设备的创建和使用。这项工作汇集了有机合成，表面化学，分析化学，材料科学和电气工程等学科。