Nucleophilic amination with an azanide surrogate

与氮氧化物替代物的亲核胺化

• 批准号: 2905473
• 金额: --
• 依托单位: University of Manchester
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2905473
• 关键词: Nucleophilic; amination; azanide; surrogate

The aim of this project is to develop a transition-metal-free approach to nucleophilic amination by developing an easily handled azanide surrogate reagent compatible with the radical-nucleophilic substitution chain mechanism. To realise this aim, we must design an optimal azanide surrogate reagent and determine "what properties and conditions are essential for experimental reaction performance?".To maximise the impact of the developed reagent, we must ascertain "which electrophiles are compatible with this reagent?", "What are the limitations of this approach?".Finally, by performing industrial case studies we will question "how does this approach compare with established industrial processes?", "What medicines can we manufacture in a more sustainable fashion?".This project will primarily seek to establish experimental proof of concept and lies in two EPSRC research themes: 'Manufacturing the future' and 'Physical sciences'. Within these themes, this work is relevant to two major EPSRC research areas: 'Synthetic Organic Chemistry' and 'Chemical Reaction Dynamics and Mechanisms'.

该项目的目的是通过开发一种易于处理且与自由基亲核取代链机制兼容的叠氮化物替代试剂，开发一种无过渡金属的亲核胺化方法。为了实现这一目标，我们必须设计一种最佳的叠氮化物替代试剂，并确定“哪些性质和条件对于实验反应性能至关重要？”。为了最大限度地发挥所开发试剂的影响，我们必须确定“哪些亲电子试剂与该试剂兼容？” ”，“这种方法的局限性是什么？”。最后，通过进行工业案例研究，我们将提出“这种方法与现有工业流程相比如何？”，“我们可以以更可持续的方式生产哪些药物？”。该项目将主要寻求建立实验性的概念验证在于 EPSRC 的两个研究主题：“制造未来”和“物理科学”。在这些主题中，这项工作与 EPSRC 的两个主要研究领域相关：“合成有机化学”和“化学反应动力学和机理”。