Central Obesity and Health Risk: Optimal MRI Measurement & Location in Children

中心性肥胖与健康风险：最佳 MRI 测量

• 批准号: 7282637
• 负责人: WEI SHEN
• 金额: $ 15.67万
• 依托单位: ST. LUKE'S-ROOSEVELT INST FOR HLTH SCIS
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-08-16 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7282637
• 关键词: Abdomen; Adipose tissue; Adult; Affect; Age; Area; Biological; Blood Pressure; Body Composition; Body Water; Body mass index; Bromides; Central obesity; Characteristics; Child; Child health care; Childhood; Data; Data Set; Databases; Deposition; Deuterium; Drug or chemical Tissue Distribution; Dual-Energy X-Ray Absorptiometry; End Point; Evaluation; Fasting; Fatty acid glycerol esters; Genes; Glucose; Health; Height; High Density Lipoprotein Cholesterol; Homeostasis; Hormones; Human; Image; Individual; Insulin; Investigation; Knowledge; Link; Lipids; Location; Magnetic Resonance Imaging; Measurement; Measures; Mesentery; Meta-Analysis; Metabolic; Metabolism; Methods; Modeling; Morbidity - disease rate; Numbers; Obesity; Pediatrics; Peritoneal; Pharmaceutical Preparations; Phenotype; Physiological; Plasma; Positioning Attribute; Protocols documentation; Psyche structure; Puberty; Publishing; Race; Radiation; Range; Reporting; Research Personnel; Rice; Risk; Role; Sampling; Scanning; Slice; Solutions; Staging; Standards of Weights and Measures; Testing; Tissues; Triglycerides; Visceral; Water; X-Ray Computed Tomography; base; energy balance; extracellular; glucose metabolism; improved; indexing; insight; intraperitoneal; mature animal; model development; obesity risk; programs; sex; size

DESCRIPTION (provided by applicant): Children are increasingly becoming an important segment of the nation's obese population and the impact of excess adiposity on the long-term health of children may exceed that of their adult counterparts. The study of adipose tissue (AT) metabolic activity and distribution provides insights into health-associated risks of pediatric obesity. In adults, although total body AT mass may be large, only specific relatively small, highly-active compartments are strongly associated with morbidity. Visceral adipose tissue (VAT), the most studied of these compartments, is central to phenotyping humans for obesity. Reference methods for measuring the amount of VAT, are magnetic resonance imaging (MRI) and computed tomography (CT). CT is of limited use in pediatrics because of the associated radiation exposure. The characterization and measurement of AT compartments in children poses special problems. VAT has traditionally been estimated from a single cross-sectional area at the L4-L5 intervertebral space. Recent studies suggest that intraperitoneal AT, consisting mainly of mental and mesenteric AT, is the component that most strongly links adiposity with adverse health consequences. However, there may be little or no intraperitoneal AT at the L4-L5 level in children, although deposits may be found at anatomical levels higher than L4-L5, in the upper abdomen. Our recent studies in a large sample of adults showed that an image slice at 5 to 10 cm above the L4-L5 level best represents total VAT volume. Another concern is that whole-body VAT and other regional AT components may not be accurately measured in children using current adult MRI protocols that include a "gap" (e.g., 4 cm) between images. These limitations on evaluating regional adiposity, especially VAT, in children, prompted the present proposed investigation. Our proposed aim is to assemble and analyze a database of existing subject-diverse whole-body MRI scans of children, including a unique subset of contiguous-slice scans, to identify and propose solutions to the unique adiposity imaging challenges posed by children. The assembled database will allow us to test important hypotheses related to measurement methods, imaging model development, and health risks in children. Our findings could potentially set standards for the evaluation of total body and regional AT in pediatrics, and improve study power.

描述（由申请人提供）：儿童越来越成为该国肥胖人群的重要部分，并且过剩肥胖对儿童长期健康的影响可能超过其成年人的影响。脂肪组织（AT）代谢活性和分布的研究提供了有关儿科肥胖风险的见解。在成年人中，尽管质量的总体可能很大，但只有特定的相对较小的高度活跃室与发病率密切相关。内脏脂肪组织（VAT）是这些隔室中研究最多的脂肪组织（VAT），是表型肥胖症的核心。测量增值税量的参考方法是磁共振成像（MRI）和计算机断层扫描（CT）。由于相关的辐射暴露，CT在儿科的使用有限。儿童隔室的表征和测量提出了特殊问题。传统上，从L4-L5椎间空间的一个横截面区域估算了增值税。最近的研究表明，腹膜内主要由精神和肠系膜AT组成，是最强烈将肥胖与不良健康后果联系起来的组成部分。但是，在儿童的L4-L5水平下，在L4-L5水平上可能几乎没有或根本没有腹膜，尽管在上腹部的解剖学水平上可能发现沉积物的解剖水平高于L4-L5。我们最近在大量成年人样本中的研究表明，高于L4-L5水平的5至10 cm的图像切片最佳代表总增值税。另一个问题是，使用当前的成人MRI方案在儿童中可能无法准确测量全身增值税和其他区域，该协议包括图像之间的“差距”（例如4 cm）。这些评估区域肥胖，尤其是儿童中增值税的局限性促使目前提出的调查。我们提出的目的是组装和分析现有的对儿童的全身MRI扫描的数据库，包括独特的连续扫描子集，以识别并提出解决方案，以解决儿童带来的独特肥胖成像挑战。组装的数据库将使我们能够测试与测量方法，成像模型开发和儿童健康风险有关的重要假设。我们的发现可能会设定标准标准，以评估小儿的总体和区域性，并提高研究能力。