Central Obesity and Health Risk: Optimal MRI Measurement & Location in Children

中心性肥胖与健康风险：最佳 MRI 测量

• 批准号: 8006941
• 负责人: WEI SHEN
• 金额: $ 8.05万
• 依托单位: ST. LUKE'S-ROOSEVELT INST FOR HLTH SCIS
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-02-01 至 2011-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8006941
• 关键词: Abdomen; Adipose tissue; Adult; Affect; Age; Area; Biological; Blood Pressure; Body Composition; Body Water; Body mass index; Bromides; Central obesity; Characteristics; Child; Child health care; Childhood; Data; Data Set; Databases; Deposition; Deuterium; Drug or chemical Tissue Distribution; Dual-Energy X-Ray Absorptiometry; Evaluation; Fasting; Fatty acid glycerol esters; Genes; Health; Height; High Density Lipoprotein Cholesterol; Homeostasis; Hormones; Human; Image; Individual; Insulin; Investigation; Knowledge; Link; Lipids; Location; Magnetic Resonance Imaging; Measurement; Measures; Mesentery; Meta-Analysis; Metabolic; Metabolism; Methods; Modeling; Morbidity - disease rate; Obesity; Pediatrics; Peritoneal; Pharmaceutical Preparations; Phenotype; Physiological; Plasma; Positioning Attribute; Protocols documentation; Psyche structure; Puberty; Publishing; Race; Radiation; Reporting; Research Personnel; Rice; Risk; Role; Sampling; Scanning; Slice; Solutions; Staging; Testing; Tissues; Triglycerides; Visceral; Water; X-Ray Computed Tomography; base; energy balance; extracellular; fasting glucose; glucose metabolism; imaging modality; improved; indexing; insight; intraperitoneal; mature animal; model development; obesity risk; programs; sex

DESCRIPTION (provided by applicant): Children are increasingly becoming an important segment of the nation's obese population and the impact of excess adiposity on the long-term health of children may exceed that of their adult counterparts. The study of adipose tissue (AT) metabolic activity and distribution provides insights into health-associated risks of pediatric obesity. In adults, although total body AT mass may be large, only specific relatively small, highly-active compartments are strongly associated with morbidity. Visceral adipose tissue (VAT), the most studied of these compartments, is central to phenotyping humans for obesity. Reference methods for measuring the amount of VAT, are magnetic resonance imaging (MRI) and computed tomography (CT). CT is of limited use in pediatrics because of the associated radiation exposure. The characterization and measurement of AT compartments in children poses special problems. VAT has traditionally been estimated from a single cross-sectional area at the L4-L5 intervertebral space. Recent studies suggest that intraperitoneal AT, consisting mainly of mental and mesenteric AT, is the component that most strongly links adiposity with adverse health consequences. However, there may be little or no intraperitoneal AT at the L4-L5 level in children, although deposits may be found at anatomical levels higher than L4-L5, in the upper abdomen. Our recent studies in a large sample of adults showed that an image slice at 5 to 10 cm above the L4-L5 level best represents total VAT volume. Another concern is that whole-body VAT and other regional AT components may not be accurately measured in children using current adult MRI protocols that include a "gap" (e.g., 4 cm) between images. These limitations on evaluating regional adiposity, especially VAT, in children, prompted the present proposed investigation. Our proposed aim is to assemble and analyze a database of existing subject-diverse whole-body MRI scans of children, including a unique subset of contiguous-slice scans, to identify and propose solutions to the unique adiposity imaging challenges posed by children. The assembled database will allow us to test important hypotheses related to measurement methods, imaging model development, and health risks in children. Our findings could potentially set standards for the evaluation of total body and regional AT in pediatrics, and improve study power.

描述（由申请人提供）：儿童日益成为全国肥胖人口的重要组成部分，过度肥胖对儿童长期健康的影响可能超过成人。对脂肪组织 (AT) 代谢活动和分布的研究为了解儿童肥胖的健康相关风险提供了见解。在成人中，尽管全身 AT 质量可能很大，但只有特定的相对较小、高活性的区室与发病率密切相关。内脏脂肪组织 (VAT) 是这些区室中研究最多的，对于人类肥胖表型分析至关重要。测量增值税金额的参考方法是磁共振成像 (MRI) 和计算机断层扫描 (CT)。由于相关的辐射暴露，CT 在儿科中的应用有限。儿童 AT 室的表征和测量提出了特殊的问题。传统上，VAT 是根据 L4-L5 椎间隙的单个横截面积来估算的。最近的研究表明，腹膜内 AT 主要由精神和肠系膜 AT 组成，是与肥胖与不良健康后果最密切相关的组成部分。然而，儿童的 L4-L5 水平可能很少或没有腹膜内 AT，尽管在上腹部高于 L4-L5 的解剖水平可能会发现沉积物。我们最近对大量成人样本的研究表明，L4-L5 水平上方 5 至 10 厘米处的图像切片最能代表增值税总额。另一个担忧是，使用当前的成人 MRI 协议可能无法准确测量儿童的全身 VAT 和其他区域 AT 成分，这些协议包括图像之间的“间隙”（例如 4 厘米）。评估儿童局部肥胖（尤其是增值税）的这些局限性促使了目前拟议的调查。我们提出的目标是组装和分析现有的儿童主题多样化全身 MRI 扫描数据库，包括连续切片扫描的独特子集，以确定儿童提出的独特肥胖成像挑战并提出解决方案。组装的数据库将使我们能够测试与测量方法、成像模型开发和儿童健康风险相关的重要假设。我们的研究结果可能为儿科全身和局部 AT 的评估制定标准，并提高研究能力。