Molecular Pathology of Cancer Training Grant

癌症分子病理学培训补助金

• 批准号: 7284784
• 负责人: MARK P KAMPS
• 金额: $ 18.77万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-07-01 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7284784
• 关键词: Grant; Malignant Neoplasms; Training; molecular pathology

DESCRIPTION (provided by applicant): This is a revised renewal for the Molecular Pathology of Cancer Training Grant within the Molecular Pathology Graduate Program (MPGP) at UCSD School of Medicine. The purpose of this grant is to train predoctoral students to carry out cancer research based on a comprehensive knowledge of the molecular and cellular biology of cancer cells, of normal histology and cancer pathology, and of current cancer treatment. The training grant faculty are within the Cancer Biology Group of the MPGP, are located at UCSD School of Medicine, The Burnham Institute, and The Scripps Research Institute. The faculty are leaders in their fields of cancer research, which cover most topics in cancer cell biology, including alterations in signal transduction pathways involving protein kinases and phosphatases, mutations and/or altered expression of proto-oncogenes and tumor suppressor genes, the role of extracellular matrix and cell surface carbohydrates in cell adhesion and metastasis, genetic instability and chromosomal translocations, apoptosis, differentiation arrest in leukemia, the immune response to cancer cells, drug development, and cancer therapy. The Cancer Biology curriculum requires classes in The Molecular Pathology of Cancer, Mouse Models for Human Disease, Advanced Cancer Pathology, and two advanced electives in Human Genetics, Developmental Biology, Immunology, Biochemistry, Structural Biology, or Molecular Modeling (selected according to trainees research area). Students select a second Molecular Pathology class in human disease (Neurologic & Muscle disease, Cardiovascular development & disease, or Microbial Pathogenesis) to broaden their understanding of human disease. Trainees rotate through 3 laboratories prior to selecting their thesis advisor. In year 2, trainees take the Minor Proposition examination, which teaches them how to write an NIH-style grant, and evaluates their overall academic progress. To understand current cancer treatment and the need for molecular therapeutics, trainees attend a clinical conference, choosing among Tumor board, Breast Pathology, OB/GYN tumor board, and Hematology/oncology. They present annually at our MPGP Spring Research Retreat, at the annual Salk Institute meetings on Oncogenes or The Cell Cycle, and at Cancer Journal Club. They invite special seminar speakers annually. This training in molecular pathology of cancer combined with a basic understanding of medical oncology and cancer therapy is unique at UCSD.

描述（由申请人提供）：这是UCSD医学院分子病理研究生计划（MPGP）中癌症培训赠款分子病理的修订续约。这项赠款的目的是培训术前学生，基于对癌细胞的分子和细胞生物学，正常组织学和癌症病理学以及当前癌症治疗的综合知识进行癌症研究。培训补助金教师位于MPGP的癌症生物学小组内，位于UCSD医学院，伯纳姆研究所和Scripps研究所。 The faculty are leaders in their fields of cancer research, which cover most topics in cancer cell biology, including alterations in signal transduction pathways involving protein kinases and phosphatases, mutations and/or altered expression of proto-oncogenes and tumor suppressor genes, the role of extracellular matrix and cell surface carbohydrates in cell adhesion and metastasis, genetic instability and chromosomal translocations,凋亡，白血病的分化停滞，对癌细胞的免疫反应，药物发育和癌症治疗。 癌症生物学课程需要在癌症分子病理学，人类疾病的小鼠模型，晚期癌症病理学以及两个人类遗传学的两种晚期选修课中进行课程， 发育生物学，免疫学，生物化学，结构生物学或分子建模（根据受训者研究领域选择）。学生在人类疾病（神经和肌肉疾病，心血管发育与疾病或微生物发病机理）中选择第二个分子病理学类，以扩大对人类疾病的理解。在选择论文顾问之前，学员在3个实验室中旋转。在第二年，学员参加了次要的命题考试，该命题教会他们如何撰写NIH风格的赠款，并评估他们的整体学业进步。为了了解当前的癌症治疗以及对分子治疗的需求，学员参加了临床会议，在肿瘤板，乳房病理学，OB/GYN肿瘤板和血液学/肿瘤学中选择。他们每年在我们的MPGP春季研究务虚会，在年度Salk Institute关于Oncogenes或细胞周期的会议上以及在Cancer Journal Club举行。他们每年邀请特别研讨会演讲者。在UCSD中，这种对癌症分子病理学的培训以及对医学肿瘤学和癌症治疗的基本了解是独一无二的。