Molecular Pathology of Cancer Training Grant

癌症分子病理学培训补助金

• 批准号: 7101824
• 负责人: MARK P KAMPS
• 金额: $ 16.77万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-07-01 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7101824
• 关键词: Molecular; Pathology; Cancer; Training; Grant

DESCRIPTION (provided by applicant): This is a revised renewal for the Molecular Pathology of Cancer Training Grant within the Molecular Pathology Graduate Program (MPGP) at UCSD School of Medicine. The purpose of this grant is to train predoctoral students to carry out cancer research based on a comprehensive knowledge of the molecular and cellular biology of cancer cells, of normal histology and cancer pathology, and of current cancer treatment. The training grant faculty are within the Cancer Biology Group of the MPGP, are located at UCSD School of Medicine, The Burnham Institute, and The Scripps Research Institute. The faculty are leaders in their fields of cancer research, which cover most topics in cancer cell biology, including alterations in signal transduction pathways involving protein kinases and phosphatases, mutations and/or altered expression of proto-oncogenes and tumor suppressor genes, the role of extracellular matrix and cell surface carbohydrates in cell adhesion and metastasis, genetic instability and chromosomal translocations, apoptosis, differentiation arrest in leukemia, the immune response to cancer cells, drug development, and cancer therapy. The Cancer Biology curriculum requires classes in The Molecular Pathology of Cancer, Mouse Models for Human Disease, Advanced Cancer Pathology, and two advanced electives in Human Genetics, Developmental Biology, Immunology, Biochemistry, Structural Biology, or Molecular Modeling (selected according to trainees research area). Students select a second Molecular Pathology class in human disease (Neurologic & Muscle disease, Cardiovascular development & disease, or Microbial Pathogenesis) to broaden their understanding of human disease. Trainees rotate through 3 laboratories prior to selecting their thesis advisor. In year 2, trainees take the Minor Proposition examination, which teaches them how to write an NIH-style grant, and evaluates their overall academic progress. To understand current cancer treatment and the need for molecular therapeutics, trainees attend a clinical conference, choosing among Tumor board, Breast Pathology, OB/GYN tumor board, and Hematology/oncology. They present annually at our MPGP Spring Research Retreat, at the annual Salk Institute meetings on Oncogenes or The Cell Cycle, and at Cancer Journal Club. They invite special seminar speakers annually. This training in molecular pathology of cancer combined with a basic understanding of medical oncology and cancer therapy is unique at UCSD.

描述（由申请人提供）：这是加州大学圣地亚哥分校医学院分子病理学研究生计划 (MPGP) 内癌症分子病理学培训补助金的修订续订。这笔赠款的目的是培训博士前学生根据癌细胞的分子和细胞生物学、正常组织学和癌症病理学以及当前癌症治疗的综合知识开展癌症研究。培训资助教师隶属于 MPGP 的癌症生物学组，分别位于加州大学圣地亚哥分校医学院、伯纳姆研究所和斯克里普斯研究所。该学院的教师是各自癌症研究领域的领导者，涵盖癌细胞生物学的大多数主题，包括涉及蛋白激酶和磷酸酶的信号转导途径的改变、原癌基因和抑癌基因的突变和/或表达改变、细胞外基质和细胞表面碳水化合物在细胞粘附和转移、遗传不稳定性和染色体易位、细胞凋亡、白血病分化停滞、对癌细胞的免疫反应、药物开发和癌症治疗中的作用。 癌症生物学课程需要癌症分子病理学、人类疾病小鼠模型、高级癌症病理学以及两门人类遗传学高级选修课， 发育生物学、免疫学、生物化学、结构生物学或分子建模（根据学员研究领域选择）。学生选择第二门人类疾病分子病理学课程（神经和肌肉疾病、心血管发育和疾病或微生物发病机制），以拓宽他们对人类疾病的理解。在选择论文导师之前，学员将轮流通过 3 个实验室。在第二年，学员参加次要命题考试，该考试教他们如何撰写 NIH 风格的补助金，并评估他们的整体学术进步。为了了解当前的癌症治疗和分子治疗的需求，学员参加临床会议，在肿瘤委员会、乳腺病理学、妇产科肿瘤委员会和血液学/肿瘤学中进行选择。他们每年都会在我们的 MPGP 春季研究静修会上、索尔克研究所关于癌基因或细胞周期的年度会议以及癌症杂志俱乐部上发表演讲。他们每年都会邀请特别研讨会演讲者。这种癌症分子病理学培训与对肿瘤内科和癌症治疗的基本了解相结合，在加州大学圣地亚哥分校是独一无二的。