Heart-Lung Physiology: Molecular-Systemic Integration

心肺生理学：分子系统整合

• 批准号: 7247205
• 负责人: WILLIAM P SCHILLING
• 金额: $ 32.77万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-07-01 至 2009-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7247205
• 关键词: Heart; Lung; Molecular; Physiology

DESCRIPTION (provided by applicant): This is a competing renewal application for training graduate students and post-doctoral fellows (MD and Ph.D) in cardio-respiratory physiology that has been in operation since July 1999. This proposal continues to focus on training in integration of cellular and molecular information to the overall function of the body. Rationale: A shift in research emphasis from systems to cellular and molecular physiology has resulted in a steady decline of well trained individuals in systems physiology at a time when genetic technology and non-invasive approaches for monitoring physiological functions have advanced creating a major need for individuals trained in this area. The major goals of this program continues to be: "1) providing training in interdisciplinary sciences with a focus on integrating function of the cardiorespiratory systems at the molecular, cellular, organ, and whole animal or human levels, and 2) provide a broad-based foundation in structure and function of cardio-respiratory systems with an emphasis on "problem-solving skills". The proposed faculty have established research programs in cardio-respiratory physiology and trained a number successful scientists. They employ a vast repertoire of approaches to study cardio-respiratory systems ranging from whole body physiology to cellular and molecular biology to computational modeling. They represent 6 basic science and 2 clinical Science departments at CWRU School of Medicine. This training program facilitate already existing collaborations amongst the proposed faculty and continues to have a major impact on training and future research in cardio-respiratory physiology at CWRU. The pre-doetoral trainees will be enrolled in the graduate program and will be offered courses specifically designed for integrated aspects of cardio-respiratory physiology, fundamentals of molecular and cell biology, laboratory rotations, seminars, journal clubs and grand rounds and supervised research. Post-doctoral trainees in this program are of two kinds: 1) cardiology and/or pulmonary clinical fellows; and 2) Ph.D. post-doctoral trainees. Research training for post-doctoral trainees is supplemented with appropriate advanced courses, seminars, journal clubs, and grand rounds. In the current training period, 8 pre-doctoral trainees and 7 post-doctoral trainees (4 Ph.D's and 3 MDs) have been recruited, and half of them have successfully completed training. Our proposed training program, which emphasizes crossing of departmental barriers and scientific disciplines, continues to develop well-rounded scientists trained in integrated aspects of cardio-respiratory physiology.

描述（由申请人提供）： 这是针对培训研究生和博士后研究生（MD和Ph.D）的竞争性更新申请，自1999年7月以来一直在运作。该提案继续专注于培训蜂窝和分子信息与身体整体功能的培训。 基本原理：在遗传技术和非侵入性方法监测生理功能的过程中，研究重点从系统到细胞和分子生理的转变导致训练有素的个体在系统生理学中的稳定下降，从而为在该领域培训的个体创造了主要需求。 该计划的主要目标继续是：“ 1）提供跨学科科学的培训，重点是整合心肺的功能 分子，细胞，器官和整个动物或人类水平的系统，以及2）为心脏呼吸系统的结构和功能提供了广泛的基础，重点是“解决问题的技能”。 拟议中的教师已经建立了心脏呼吸生理学的研究计划，并培训了许多成功的科学家。 他们采用了大量的方法来研究从整个身体生理学到细胞和分子生物学再到计算建模的心脏呼吸系统。 它们代表CWRU医学院的6个基础科学和2个临床科学系。 该培训计划促进了拟议教职员工之间已经存在的合作，并继续对CWRU的心脏呼吸生理学的培训和未来研究产生重大影响。 培训前学员将参加研究生课程，并将提供专门为心脏呼吸生理学，分子和细胞生物学基础知识，实验室轮换，研讨会，期刊俱乐部，俱乐部以及盛大的回合和监督研究的课程。 该计划的博士后学员有两种：1）心脏病学和/或肺临床研究员；和2）博士博士后学员。 博士后学员的研究培训补充了适当的高级课程，研讨会，期刊俱乐部和大回合。 在当前的培训期间，已经招募了8名博士后学员和7名博士后学员（4个博士学位和3名MDS），其中一半成功完成了培训。 我们提出的培训计划强调了部门障碍和科学学科的穿越，继续开发经过全面的科学家，受过心脏呼吸生理的综合方面培训。