Training and Research in Colon Cancer Survival

结肠癌生存培训和研究

• 批准号: 9751785
• 负责人: POLLY A NEWCOMB
• 金额: $ 8.9万
• 依托单位: FRED HUTCHINSON CANCER RESEARCH CENTER
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9751785
• 关键词: Age; Area; Award; BRAF gene; Behavioral Genetics; Biology; Cancer Control; Cancer Etiology; Cancer Survivor; Cancer Survivorship; Caregivers; Cessation of life; Characteristics; Clinical Research; Collaborations; Colon Carcinoma; Colonic Neoplasms; Colorectal Cancer; Colorectal Neoplasms; Complex; CpG Island Methylator Phenotype; Data; Developed Countries; Developing Countries; Development; Diagnosis; Disease; Epidemiologic Factors; Epidemiology; Europe; Funding; Future; Generations; Genetic; Genetic Variation; Goals; Grant; Growth; Individual; International; Joints; KRAS2 gene; Knowledge; Longevity; Malignant Neoplasms; Manuscripts; Mentors; Mentorship; Methods; Microsatellite Instability; Molecular; Mutation; North America; Obesity; Observational Study; Outcome; Participant; Patients; Population; Postdoctoral Fellow; Preparation; Prevention Research; Principal Investigator; Production; Recording of previous events; Reporting; Research; Research Personnel; Research Project Grants; Research Support; Resources; Risk Factors; Sample Size; Scientist; Senior Scientist Award; Smoking; Survival Analysis; Testing; Training; Training Support; Tumor Markers; United States; United States National Institutes of Health; Universities; Validation; Washington; Woman; Work; Writing; cancer diagnosis; cancer epidemiology; cancer genome; cancer prevention; cancer survival; career; cohort; colon cancer family registry; colon cancer patients; data registry; design; experience; follow-up; genetic epidemiology; genetic variant; improved; insight; men; molecular subtypes; mortality; pre-doctoral; predictive modeling; public health relevance; responsible research conduct; screening; sex; skills; study population; success; tumor

 DESCRIPTION (provided by applicant): This is a renewal of an Established Investigator award for Dr. Polly Newcomb to dedicate 30% effort to training and research in colorectal cancer survivorship. She is an experienced cancer prevention and control investigator with a long and successful record of continuous NIH-funding, with nearly $40 M in direct awards to her as Principal Investigator. An effective mentor, she has worked with over 40 young scientists on their way to independent careers in cancer prevention and control. This K05 has allowed her to focus her career on the epidemiology and genetics of colon cancer survival. With support of the K05 she has obtained additional skills, had 4 R01 proposals funded as PI, and worked with 24 outstanding junior investigators to author ~70 study reports focused on cancer survivorship. The epidemiology of cancer survival continues to be an essential area, as the population of cancer survivors is rapidly growing because of screening and treatment successes; today more than 14 million U.S. individuals have a history of cancer. Therefore, identifying approaches to improve survival in colorectal cancer patients is a high priority for patients, clinicians, and caregivers. Colorectal cancer is a complex disease caused by the joint action of environmental, behavioral, and genetic factors; longevity after diagnosis too must reflect these joint effects. The research goals of this K05 awards are to: 1) Further develop and actively participate in the newly emerging International Survival Analysis of Colorectal Cancer Consortium (ISACC) that currently includes 23 studies and nearly 27,000 colorectal cancers, in order to initiate research projects with Consortium investigators and mentees to leverage the diverse and well-annotated populations and biospecimens collected by the participating studies; 2) Test whether the colon tumor genome, as defined by BRAF mutation, KRAS mutation, CpG Island Methylator Phenotype (CIMP), and microsatellite instability (MSI) status, is associated with colorectal cancer survival, and assess whether this association is modified by epidemiologic factors or common germline genetic variants; and 3) Develop and validate a prognostic model for survival utilizing the tumor genome, epidemiologic factors, and germline genetic variants. Cancer survivorship is a challenging area of prevention research with unique methods for analyses and controlling bias, making mentorship of junior investigators key to the successful production of significant and impactful research results. There is an outstanding pool of pre- and post-doctoral trainees from the University of Washington, with mentee funding available from 4 training grants with which Dr. Newcomb serves as a mentor and/or on the Executive Committee. Dr. Newcomb regularly meets with trainees individually, and weekly as a group, to develop expertise in study conduct, analyses, manuscript preparation, grant writing, and the responsible conduct of research. The renewal of the K05 award will be an invaluable mechanism to better understand the factors that can enhance cancer survival, and in doing so, develop junior researchers highly skilled in cancer control.

 描述（由申请人提供）：这是对 Polly Newcomb 博士的“知名研究者奖”的续签，旨在将 30% 的精力用于结直肠癌生存的培训和研究。她是一位经验丰富的癌症预防和控制研究者，拥有长期成功的记录。作为首席研究员，她获得了 NIH 的持续资助，并获得了近 4000 万美元的直接奖励，她与 40 多名年轻科学家一起在癌症预防和控制领域走向独立职业生涯。 K05 让她能够将自己的职业生涯集中在结肠癌生存的流行病学和遗传学上。在 K05 的支持下，她获得了额外的技能，作为 PI 资助了 4 项 R01 提案，并与 24 名杰出的初级研究人员合作撰写了约 70 份研究报告。癌症生存的流行病学仍然是一个重要领域，由于筛查和治疗的成功，癌症幸存者的人数正在迅速增长；如今，超过 1400 万美国人有癌症生存史；因此，确定提高结直肠癌患者生存率的方法是患者、公众和护理人员的首要任务。 结直肠癌是一种由环境、行为和遗传因素共同作用引起的复杂疾病；诊断后的寿命也必须反映这些共同作用，本次K05奖的研究目标是：1）进一步发展并积极参与新的研究。新兴的国际结直肠癌生存分析联盟 (ISACC) 目前包括 23 项研究和近 27,000 例结直肠癌，以便与联盟研究人员和学员一起启动研究项目，以利用多样化和参与研究收集的注释明确的群体和生物样本；2) 测试结肠肿瘤基因组（根据 BRAF 突变、KRAS 突变、CpG 岛甲基化表型 (CIMP) 和微卫星不稳定性 (MSI) 状态）是否与结直肠癌相关癌症生存，并评估这种关联是否受到流行病学因素或常见种系遗传变异的影响；3) 利用肿瘤基因组开发和验证生存预后模型，癌症生存是预防研究的一个具有挑战性的领域，具有独特的分析和控制偏差方法，这使得初级研究人员的指导成为成功产生重要和有影响力的研究成果的关键。来自华盛顿大学的博士前和博士后学员，由纽科姆博士作为导师和/或执行委员会的 4 项培训补助金提供学员资助，纽科姆博士每周定期与学员单独会面。作为一个团体，发展K05 奖的更新将成为一个宝贵的机制，可以更好地了解可提高癌症生存率的因素，并在此过程中培养初级研究人员。具有高度的癌症控制能力。

项目成果

Urinary Cadmium and Risk of Invasive Breast Cancer in the Women's Health Initiative.

妇女健康倡议中的尿镉和侵袭性乳腺癌风险。

• DOI: 10.1093/aje/kwv285
• 发表时间: 2016-05-01
• 期刊: American journal of epidemiology
• 影响因子: 5
• 作者: S. Adams;M. Shafer;M. Bonner;A. LaCroix;J. Manson;J. Meliker;M. Neuhouser;P. Newcomb
• 通讯作者: P. Newcomb

Oral bisphosphonate use and colorectal cancer incidence in the Women's Health Initiative.

妇女健康倡议中口服双磷酸盐的使用和结直肠癌的发病率。

• 发表时间: 2013-09
• 作者: Passarelli, Michael N;Newcomb, Polly A;LaCroix, Andrea Z;Lane, Dorothy S;Ho, Gloria Y F;Chlebowski, Rowan T
• 通讯作者: Chlebowski, Rowan T

Urinary cadmium as a marker of exposure in epidemiological studies.

尿镉作为流行病学研究中暴露的标志。

• 发表时间: 2013-10
• 影响因子: 10.4
• 作者: Adams, Scott V;Newcomb, Polly A
• 通讯作者: Newcomb, Polly A

Reply to F. Tomao et al.

回复 F. Tomao 等人。

• 发表时间: 2015-11-01
• 作者: Newcomb, Polly A;Passarelli, Michael N
• 通讯作者: Passarelli, Michael N

Financial Insolvency as a Risk Factor for Early Mortality Among Patients With Cancer.

财务破产是癌症患者早期死亡的危险因素。

• DOI: 10.1200/jco.2015.64.6620
• 发表时间: 2016-09-19
• 期刊: Journal of clinical oncology : official journal of the American Society of Clinical Oncology
• 作者: S. Ramsey;A. Bansal;C. Fedorenko;D. Blough;Karen A. Overstreet;V. Shankaran;P. Newcomb
• 通讯作者: P. Newcomb