Training in Engineered Biomaterials

工程生物材料培训

• 批准号: 7277317
• 负责人: Buddy D Ratner
• 金额: $ 20.54万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-07-01 至 2009-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7277317
• 关键词: Biocompatible Materials; Engineering; Training

DESCRIPTION (provided by applicant): This proposal seeks to support the training of 9-12 Ph.D. students in the interdisciplinary field of Engineered Biomaterials. The training opportunities in the program encompass aspects of the engineering disciplines (Chemical Engineering, Materials Science Engineering, Bioengineering and Electrical Engineering), and the biological and physical sciences (Chemistry, Biology, Molecular Biology). The program is designed to provide an interdisciplinary education for graduate students in Chemical Engineering, Chemistry, Bioengineering, Materials Science Engineering and Electrical Engineering by integrating materials science, surface engineering, molecular biology, nanotechnology, chemistry, chemical engineering and medicine. In this training, graduate students will complete a series of core courses in basic engineering, biology, mathematics, and chemistry in accordance with individual departmental guidelines. Trainees will also complete specific courses in biomaterials engineering including courses such as molecular and cellular bioengineering, molecular recognition and design, molecular materials, biomaterials, and cellular interactions with biomaterials. Students will conduct thesis research under the guidance of the training program faculty that emphasizes the application of engineering principals to the design and development of biomaterials that exploit specific biological recognition mechanisms. Trainees in the Engineered Biomaterials program will learn to control biological reactions at interfaces with precision, to elucidate the biochemical/biological pathways that turn on healing and reconstruction, and to evolve implementable strategies to modify the surfaces of biomaterials and medical devices so they are recognized by the body and turn on healing and defined bioreactions. In addition, students will be exposed to the broader issues in biomaterials engineering and related disciplines via participation in research seminars, journal clubs, and attendance at national scientific meetings. The trainee' s educational experience will be further enhanced by opportunities to obtain experience in teaching, opportunities for industrial intemships, and by student workshops and seminars on issues of interest such as career opportunities. Trainees will be selected from highly qualified graduate students in the departments of Chemical Engineering, Bioengineering, Electrical Engineering, Chemistry and Materials Science and Engineering following completion of the qualifying exam and will be based on academic record, faculty recommendation, and a description of proposed research. Trainees will participate in the training program for a period of 2 years.

描述（由申请人提供）：该提案旨在支持9-12博士学位的培训。工程生物材料跨学科领域的学生。该计划中的培训机会包括工程学科的各个方面（化学工程，材料科学工程，生物工程和电气工程）以及生物学和物理科学（化学，生物学，分子生物学）。该计划旨在为化学工程，化学，生物工程，材料科学工程和电气工程的研究生提供跨学科教育，并通过整合材料科学，表面工程，分子生物学，纳米技术，化学，化学工程和医学。在这项培训中，研究生将根据个人部门指南完成一系列基础工程，生物学，数学和化学的核心课程。学员还将完成生物材料工程的特定课程，包括分子和细胞生物工程，分子识别和设计，分子材料，生物材料以及与生物材料的细胞相互作用。学生将在培训计划学院的指导下进行论文研究，该研究强调工程校长在利用特定生物学识别机制的生物材料的设计和开发中的应用。工程生物材料计划中的学员将学会控制界面处的生物反应，以阐明开发愈合和重建的生化/生物学途径，并进化可实施的策略，以修改生物材料和医疗设备的表面，以便被身体识别，并被康复和固定固定的疗养和固定化。此外，学生将通过参加研究研讨会，期刊俱乐部和参加国家科学会议的活动来了解生物材料工程和相关学科的更广泛问题。学员的教育经验将通过获得教学的经验，工业直觉的机会以及学生讲习班和有关兴趣问题（例如职业机会等问题）的研讨会的机会进一步增强。学员将从化学工程，生物工程，电气工程，化学和材料科学和工程学的高素质研究生中选拔，并将基于学术记录，教职员工建议以及拟议的研究的描述。学员将参加培训计划2年。

项目成果

A ligand-mediated nanovector for targeted gene delivery and transfection in cancer cells.

• DOI: 10.1016/j.biomaterials.2008.10.003
• 发表时间: 2009-02
• 期刊: BIOMATERIALS
• 影响因子: 14
• 作者: Veiseh, Omid;Kievit, Forrest M.;Gunn, Jonathan W.;Ratner, Buddy D.;Zhang, Miqin
• 通讯作者: Zhang, Miqin

Design and fabrication of magnetic nanoparticles for targeted drug delivery and imaging.

• DOI: 10.1016/j.addr.2009.11.002
• 发表时间: 2010-03-08
• 期刊: ADVANCED DRUG DELIVERY REVIEWS
• 影响因子: 16.1
• 作者: Veiseh, Omid;Gunn, Jonathan W.;Zhang, Miqin
• 通讯作者: Zhang, Miqin

Complement activation on poly(ethylene oxide)-like radiofrequency glow discharge-deposited surfaces.

• DOI: 10.1002/jbm.a.32954
• 发表时间: 2011-01
• 期刊: JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
• 影响因子: 4.9
• 作者: Szott, Luisa Mayorga;Stein, M. Jeanette;Ratner, Buddy D.;Horbett, Thomas A.
• 通讯作者: Horbett, Thomas A.

Structure and reactivity of adsorbed fibronectin films on mica.

云母上吸附的纤连蛋白膜的结构和反应性。

• DOI: 10.1529/biophysj.107.109819
• 发表时间: 2007
• 期刊: Biophysical journal
• 影响因子: 3.4
• 作者: Hull,JamesR;Tamura,GlenS;Castner,DavidG
• 通讯作者: Castner,DavidG

Inhibition of tumor-cell invasion with chlorotoxin-bound superparamagnetic nanoparticles.

• DOI: 10.1002/smll.200800646
• 发表时间: 2009-02
• 期刊: SMALL
• 影响因子: 13.3
• 作者: Veiseh, Omid;Gunn, Jonathan W.;Kievit, Forrest M.;Sun, Conroy;Fang, Chen;Lee, Jerry S. H.;Zhang, Miqin
• 通讯作者: Zhang, Miqin