Fabrication and Evaluation of Poly(glycerol sebacate) based small diameter vascular graft as a potent substitution for autologous vessels

基于聚（甘油癸二酸酯）的小直径血管移植物作为自体血管有效替代品的制造和评估

• 批准号: 2897580
• 金额: --
• 依托单位: University of Sheffield
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2897580
• 关键词: Fabrication; Evaluation; Poly; glycerol; sebacate

Cardiovascular diseases are recognized as the main cause of mortality rate globally. They originate from narrowing or blockage of blood vessels. Decreasing blood flow could disrupt blood circulation performance and cause myocardial infarction, arterial disease and thrombosis, and tissue damage. Many therapeutic strategies have been applied from medications to angioplasty, stent insertion, or grafting autologous arteries or veins. Vascular bypass grafting is often employed, however is often a lack of suitable, good quality vasculature to sue as an autologous graft. Consequently, the importance of widening research in synthetic polymeric grafts is irrefutable. Commercial synthetic large-diameter products fabricated from polytetrafluoroethylene (PTFE, Teflon) and polyethylene terephthalate (PET, Dacron), are already on the market, but are not a suitable candidate for small-diameter grafts. Due to their improper compliance and elasticity, they are prone to intimal hyperplasia. Hence, research has focussed on the engineering of small-diameter vessel tissues over the last few years. The aim of the project is to design and fabricate a cost-effective and off-the-shelf small-diameter vascular graft to potentially mimic the natural vessel. Poly(glycerol sebacate) (PGS) is a good choice for small-diameter vessel tissue engineering because of its tuneable mechanical properties, elasticity, biocompatibility, biodegradability, hemocompatibility, inexpensiveness, and transparency. This project hypothesizes that a more durable PGS derivatives could support smooth muscle cells and the addition of some groups like methacrylate, and polycarbonate polyols could control the mechanical strength and biodegradability. Moreover, the PGS modification with nanofillers like Polyhedral oligomeric silsesquioxane (POSS), could not only have a positive impact on increasing elasticity but also hemocompatibility through its anti-protein and anti-platelet adsorption properties.

心血管疾病被认为是全球死亡率的主要原因。它们源于血管的狭窄或阻塞。减少血液可能会破坏血液循环的表现，并导致心肌梗塞，动脉疾病和血栓形成以及组织损伤。从药物到血管成形术，支架插入或嫁接自体动脉或静脉，已经采用了许多治疗策略。血管旁路嫁接通常是使用的，但是通常缺乏适当的，优质的脉管系统来起诉自体移植物。因此，在合成聚合物移植物中扩大研究的重要性是无可辩驳的。由聚二氟乙烯（PTFE，Teflon）和聚对苯二甲酸酯（PET，DACRON）制造的商业合成大直径产品已经在市场上，但不是适合小直径移植物的候选者。由于其不当依从性和弹性，它们容易发生增生。因此，在过去的几年中，研究集中在小直径血管组织的工程上。该项目的目的是设计和制造具有成本效益且现成的小直径血管移植物，以模仿天然容器。聚（甲酸酯）（PGS）是小直径血管组织工程的一个不错选择，因为其可调的机械性能，弹性，生物相容性，可生物降解性，血液相容性，便宜和透明度。该项目假设更耐用的PGS衍生物可以支持平滑肌细胞，并且添加了甲基丙烯酸酯等一些基团，而聚碳酸酯多元醇可以控制机械强度和生物降解性。此外，PGS对纳米填料（如多面性寡聚硅盐盐（POSS））进行了修饰，不仅可以通过其抗蛋白质和抗蛋白质和抗平台的吸附性能对增加弹性产生积极影响。