Functionally graded shape memory alloy (SMA) micro-actuators for neurosurgical applications
用于神经外科应用的功能梯度形状记忆合金 (SMA) 微执行器
基本信息
- 批准号:2894767
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:英国
- 项目类别:Studentship
- 财政年份:2023
- 资助国家:英国
- 起止时间:2023 至 无数据
- 项目状态:未结题
- 来源:
- 关键词:
项目摘要
This project will focus on the development of (predominantly) laser-based manufacturing processes to fabricate micro-actuators based on the Shape Memory effect, which can provide a high energy density movements controlled e.g. by remote heating. Nickel-titanium SMA has found many applications in medical devices due to its excellent biocompatibility coupled with its ability to change shape significantly (to a pre-programmed, i.e. memorised, state) as it crosses a transition temperature (that can be tuned by varying the alloy composition and thermomechanical treatment) close to body temperature. The particular application of interest in this project is as a switch for fluid delivery that can be remotely actuated, for prolonged treatment of brain tumours with permanently inserted catheters. The concept is a shape memory alloy valve that can be switched via remote heating e.g. by using infrared light (if close to the skin) or radio energy transfer. Laser-based manufacturing processes, including micro-welding and micro-cutting will be used to fabricate the devices with minimal heat input, to prevent unwanted changes to the remaining material properties. We have well-established expertise in these processes supported by extensive facilities. In addition, we have recently developed a modification of the laser induced forward transfer (LIFT) process for manufacturing more complex composite SMA parts which can be included into the overall design and manufacturing process.
该项目将集中于(主要)基于激光的制造工艺的开发,以根据形状记忆效应制造微型演员,这可以提供受控制的高能量动作,例如通过远程加热。 Nickel-Titanium SMA由于其出色的生物相容性而在医疗设备中发现了许多应用,加上它可以显着改变形状的能力(即预先编程(即记忆,状态),它可以穿过过渡温度(可以通过将合金组成和热力学处理方法变化来调节,并接近体温。在该项目中的特殊应用是作为流体输送的开关,可以远程驱动,以长期使用永久插入的导管对脑肿瘤进行长时间治疗。该概念是形状内存合金阀,可以通过远程加热进行切换,例如通过使用红外光(如果靠近皮肤)或无线电能量转移。基于激光的制造工艺(包括微焊接和微切割)将用于用最少的热量输入来制造设备,以防止对其余材料特性的不必要变化。我们在广泛的设施支持的这些过程中拥有良好的专业知识。此外,我们最近对激光诱导的前向转移(LIFT)过程进行了修改,以制造更复杂的复合SMA零件,该零件可包含在整体设计和制造过程中。
项目成果
期刊论文数量(0)
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专利数量(0)
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10.1038/s41598-023-40425-w - 发表时间:
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Comparison of a novel self-expanding transcatheter heart valve with two established devices for treatment of degenerated surgical aortic bioprostheses.
- DOI:
10.1007/s00392-023-02181-9 - 发表时间:
2024-01 - 期刊:
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Axotomy induces axonogenesis in hippocampal neurons through STAT3.
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10.1038/cddis.2011.59 - 发表时间:
2011-06-23 - 期刊:
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Humoral responses to the SARS-CoV-2 spike and receptor binding domain in context of pre-existing immunity confer broad sarbecovirus neutralization.
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10.3389/fimmu.2022.902260 - 发表时间:
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10.3390/ijms23105675 - 发表时间:
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