Developmental change in visuospatial processes: RT-fMRI

视觉空间过程的发育变化：RT-fMRI

基本信息

批准号：
7220057
负责人：
JOAN STILES
金额：
$ 60.18万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
2003
资助国家：
美国
起止时间：
2003-04-01 至 2009-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7220057
关键词：
Address Adolescence Adult Age Area Behavioral Brain Brain region Categories Cerebral hemisphere Cerebrovascular Circulation Child Childhood Class Classification Cognitive Collaborations Coupling Data Data Set Development Documentation Experimental Designs Face FarGo Foundations Functional Imaging Functional Magnetic Resonance Imaging Goals Image Inferior Investigation Lateral Life Location Magnetic Resonance Imaging Maps Measures Medial Mediating Methods Motor Numbers Participant Pattern Performance Physics Population Procedures Process Protocols documentation Range Regulation Research Personnel Role Sensory Series Shapes Spin Labels Stimulus Surface System Techniques Temporal Lobe Visual Visual system structure Visuospatial Work age related base blood oxygen level dependent brain morphology cognitive function neurodevelopment neuroimaging relating to nervous system response visual process visual processing visual stimulus

项目摘要

DESCRIPTION (provided by applicant): Although there has been substantial work documenting behavioral change in spatial cognitive processing, little is known about the development of the neural systems that mediate these functions. Recent advances in fMRI now make it possible to ask critical questions concerning the relations between behavioral change and change in the associated brain systems: What does it mean to say that particular brain regions mediate, or to come to mediate, certain types of processing? How do patterns of neural commitment emerge in development? Specifically, to what extent does the development of the neural systems reflect the profiles of change observed in behavioral data? The major goals of this proposal focus on documenting the relationship between developmental change in a basic aspect of spatial cognitive functioning, visual pattern processing, and change in the brain system, the ventral occipital temporal lobe system, that mediates these functions. Three series of studies are proposed. The first is focuses on mapping developmental change in the functional organization of the ventral visual system, exploring the neural organization of category specific information along the ventral surface of the temporal lobe. The second is directed toward examining change in the patterns of hemispheric lateralization for the basic cognitive processes involved in spatial pattern analysis, focusing on the separable process of configural, or global, and featural, or local, level processing. Third examines regulation of information exchange across the cerebral hemispheres, looking at the exchange of information related to global and local level processes. In addition, because all of these studies use functional Magnetic Resonance Imaging (fMRI) to address questions of brain organization in pediatric populations, this project will also investigate two methodological questions: (1) Are there changes with development in the BOLD response. Arterial spin labeling (ASL) measures will be employed to address this question; (2) Are there age-related change in brain morphology as it relates to anatomical normalization?

描述（由申请人提供）：尽管已经有实质性的工作记录了空间认知处理的行为变化，但对介导这些功能的神经系统的发展知之甚少。现在的fMRI的最新进展使得有关相关大脑系统行为变化与变化之间关系的关键问题是可能的：说特定的大脑区域介导或调解某些类型的处理是什么意思？神经承诺的模式如何发展？具体而言，神经系统的发展在多大程度上反映了行为数据中观察到的变化的概况？该提案的主要目标是记录在空间认知功能的基本方面，视觉模式处理的基本方面之间的关系，以及介导这些功能的大脑系统（腹侧枕叶颞叶系统）的变化。提出了三个系列研究。第一个重点是映射腹侧视觉系统功能组织的发展变化，探索沿颞叶腹表面的类别特定信息的神经组织。第二个是针对检查空间模式分析所涉及的基本认知过程的半球侧向化模式的变化，重点是构型，全局，全局，特征或局部级别处理的可分离过程。第三研究研究了整个大脑半球的信息交换的调节，以研究与全球和地方一级过程有关的信息交换。此外，由于所有这些研究都使用功能磁共振成像（fMRI）来解决小儿种群中大脑组织的问题，因此该项目还将研究两个方法论问题：（1）大胆反应中的发展有所改变。将采取动脉自旋标记（ASL）措施来解决这个问题；（2）与解剖学归一化有关的脑形态与年龄相关的变化吗？