Joint function throughout the life course

整个生命过程中的关节功能

基本信息

批准号：
2890982
负责人：
金额：
--
依托单位：
University of Bristol
依托单位国家：
英国
项目类别：
Studentship
财政年份：
2023
资助国家：
英国
起止时间：
2023 至无数据
项目状态：
未结题

来源：
https://gtr.ukri.org/projects?ref=studentship-2890982
关键词：
Joint function throughout life course

项目摘要

A majority of people (and many domestic pets) experience painful joint disorders such as osteoarthritis as they age. We know that mechanical loading of the joint plays a major role in joint health, yet we still have a limited understanding of how joint loading changes through life as the different tissues of the joint (inluding bone, cartilage, connective tissues and muscle) develop, are maintained and begin to degenerate. In this project using computational modeling (particularly Finite Element Analysis) along with advanced in vivo imaging (computed tomography, lightsheet, confocal and multi photon microscopy) you will study how joints are made, and maintained throughout the whole lifespan of a model organism, the zebrafish. Using transgenic reporter lines you will study how the tissues of the joint come together. Using computational modeling you will test how strain patterns change through life so that we can identify which cells are under high and low strain, and begin to unpick (using transgenic reporters and genetic mutant lines) why cells behave in certain ways in the joint as they repair damage and as they age. The project will suit someone with an interest in genetics, in vivo imaging and computational modeling. You will work with groups who have pioneered use of the techniques that the project will use. The project will give you an interdisciplinary skill set that should benefit you in your further career.

随着年龄的增长，大多数人（和许多家庭宠物）患有疼痛的关节疾病，例如骨关节炎。我们知道，关节的机械负荷在关节健康中起着重要作用，但是随着关节的不同组织（嵌入骨骼，软骨，结缔组织和肌肉）的发展，我们仍然对关节载荷如何变化有限，并保持了并开始退化。在该项目中，使用计算建模（尤其是有限元分析）以及先进的体内成像（计算机断层扫描，灯表，共聚焦和多光子显微镜），您将研究如何制作关节，并在模型生物体的整个寿命范围内制造关节，Zebrafish。使用转基因记者线，您将研究关节的组织如何聚在一起。使用计算模型，您将测试应变模式如何在生活中变化，以便我们可以确定哪些细胞在高和低应变下，并开始取消分类（使用转基因报告基因和遗传突变线），为什么细胞在修复损害以及随着年龄的年龄而在关节中表现出某些方式。该项目将适合对遗传学，体内成像和计算建模感兴趣的人。您将与已经开创了该项目将使用的技术的小组合作。该项目将为您提供跨学科的技能，该技能应该使您在进一步的职业中受益。