Secondary Analysis of Substance Use In Men

男性物质使用的二次分析

• 批准号: 7221312
• 负责人: MICHAEL FENDRICH
• 金额: $ 21.1万
• 依托单位: UNIVERSITY OF WISCONSIN MILWAUKEE
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-10 至 2009-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7221312
• 关键词: AIDS prevention; Alcohol or Other Drugs use; Alcohols; Behavior; Chicago; Cognitive; Consumption; Data Set; Dependence; Drug abuse; Drug usage; Facility Construction Funding Category; Future; General Population; HIV; HIV Infections; Illinois; Ketamine; Measurement; Measures; Methamphetamine; Modeling; Pattern; Population; Population Study; Prevalence; Prevention intervention; Probability Samples; Public Policy; Rate; Relative (related person); Reporting; Research; Risk; Risk Behaviors; Role; Sampling; Sex Behavior; Statistical Models; Structure; Surveys; Time; Validity of Self Report; base; club drug; comparative; cost; ecstasy; high risk behavior; high risk men; high risk sexual behavior; indexing; instrument; men; men who have sex with men; response; substance abuse epidemiology; theories; trend

DESCRIPTION (provided by applicant): Recent well-documented increases in the rate of new HIV infections in high risk populations coincide with the spreading popularity of club drugs such as MDMA, ketamine, GHB, & methamphetamine. This research seeks to further understand these linkages by systematically exploring the epidemiology of substance abuse among men at high risk for HIV infection. This application will conduct extensive analyses of existing data sets collected on three different probability samples obtained from Chicago, Illinois: The main comparative analyses focus on a sample of men surveyed in 1996-1997 and an additional sample of men surveyed in 2002-2003; additional comparisons will employ a sample of men surveyed as a part of a general population study of drug use in 2001-2002. Taking advantage of parallel instruments and measures across two Chicago-based samples, detailed analyses will compare and explore substance use reporting validity as well as the relative prevalence of substance use/abuse between high-risk and non-high-risk men. Guided by a "cognitive escape" conceputal framework, this application provides a unique, timely, and cost-effective opportunity for understanding shifts in substance use prevalence patterns and trends over time among high- risk men. Multivariate models will systematically examine associations between drug use and risk behavior; associations over time (across different data sets) will be compared'. In order to better understand these linkages, we will explore alternative statistical approaches for combining and scaling survey responses to questions about high risk behavior/including single parameter item response theory (Rasch Scaling) and covariance structure measurement models (using LISREL and MPLUS). These scaling approaches, in turn, will be used to refine and revise statistical models. This application will have a significant impact on public policy by further articulating the causal role of drug abuse in the spread of HIV, thus helping to guide future HIV prevention and intervention efforts.

描述（由申请人提供）：最近有充分记录的高风险种群中新艾滋病毒感染率的增加，与MDMA，氯胺酮，GHB和甲基苯丙胺等俱乐部药物的扩散流行相吻合。这项研究旨在通过系统地探索患有艾滋病毒感染的高风险的男性滥用药物的流行病学来进一步理解这些联系。该申请将对从伊利诺伊州芝加哥获得的三个不同概率样本收集的现有数据集进行广泛的分析：主要比较分析的重点是1996 - 1997年调查的男性样本以及2002 - 2003年调查的其他男性样本；其他比较将采用调查的男性样本，作为2001 - 2002年对药物使用的一般人群研究的一部分。利用两个基于芝加哥的样本的平行仪器和措施，详细的分析将比较和探索物质使用报告有效性以及高风险和非高风险男性之间物质使用/滥用的相对患病率。在“认知逃脱”污点框架的指导下，该应用程序为理解物质使用率的发生率和趋势的转变提供了独特，及时且具有成本效益的机会，而高风险男性则随着时间的流逝。多元模型将系统地检查药物使用和风险行为之间的关联；随着时间的流逝（跨不同数据集）的关联将被比较'。为了更好地理解这些联系，我们将探讨对有关高风险行为/包括单参数项目响应理论（Rasch缩放）（Rasch缩放）和协方差结构测量模型（使用Lisrel和Mplus）（使用Lisrel和Mplus）相结合和扩展调查的响应的替代统计方法。这些缩放方法反过来将用于完善和修改统计模型。该申请将通过进一步阐明药物滥用在艾滋病毒传播中的因果作用，从而对公共政策产生重大影响，从而有助于指导未来的艾滋病毒预防和干预工作。