Self-injury: Pain and Stress Mechanisms

自残：疼痛和压力机制

• 批准号: 7289888
• 负责人: FRANK J SYMONS
• 金额: $ 10.93万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-22 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7289888
• 关键词: Absence of pain sensation; Accounting; Acute; Adult; Afferent Neurons; Analgesics; Area; Autonomic nervous system; Award; Behavior; Behavior Disorders; Behavioral; Behavioral Genetics; Behavioral Mechanisms; Biological; Biology; Bite; Child; Childhood; Chronic; Clinical; Commit; Complex; Consensus; Detection; Development; Development Plans; Developmental Disabilities; Educational Psychology; Environment; Event; Fiber; Frequencies; Functional disorder; Funding; Genes; Goals; Hand; Head; Hormones; Hydrocortisone; Hyperalgesia; Hypothalamic structure; Impairment; Individual; Injury; Institution; Learning; Leg; Localized; Measures; Mediating; Medical; Minnesota; Modeling; Nature; Nerve Fibers; Nervous system structure; Neurobiology; Neurologic; Neurosciences; Nociception; Nociceptors; Opioid; Outcome Study; Pain; Pain Threshold; Pattern; Peripheral; Persons; Physiological; Physiology; Pituitary Gland; Pituitary-Adrenal System; Play; Population; Process; Psychopathology; Purpose; Recording of previous events; Regulation; Relative (related person); Research; Research Design; Research Training; Resistance; Resources; Risk; Role; Self-Injurious Behavior; Sensory; Sensory Process; Sensory Thresholds; Severities; Site; Spottings; Stimulus; Stress; Substance P; System; Testing; Time; Tissues; Training; Translational Research; Treatment outcome; Universities; Validity and Reliability; Work; allodynia; base; biobehavior; biological adaptation to stress; career; chronic neuropathic pain; desensitization; developmental disease; early experience; experience; hypothalamic-pituitary-adrenal axis; improved; neurochemistry; novel; programs; prospective; psychobiologic; psychobiology; response; skills; somatosensory; stressor; transmission process

DESCRIPTION (provided by applicant): Goals: My research has dealt primarily with the behavioral mechanisms underlying chronic SIB among individuals with developmental disorders. A more complete understanding of the pathophysiology of SIB will require integrating our rich understanding of pain neurobiology and stress psychobiology with our emerging understanding of the role of early experience on multiple pain and stress-sensitive physiological systems. Research: During my R29 funding period, I extended the opioid model of SIB in line with clinical features suggestive of altered pain processing, formed collaborative relations, and began developing the necessary expertise allowing me to seek funding to test an integrative pain and stress model of SIB in adults. The purpose of the funded R01 is to compare socially and nonsocially-mediated SIB adult cases on a set of behavioral and biological measures related to sensory function, stress physiology, and pain behavior. Career Plan: The career development plan uses a translational research training framework as an organizing set of principles to guide research and training goals specific to new developments in neuroscience and behavioral genetics, integrating the wider research program of developmental psychopathology, and expanding the self- injury research agenda to embrace gene-environmental interplay and improve our understanding of individual vulnerability. Preliminary work and collaborative relations are described to support the need for release time to enhance my training and research into these related areas. The plan emphasizes the need to extend self- injury research to issues germane to pediatric and neurological research (i.e., pain regulation, high risk populations), and to include other systems important in the regulation of pain (i.e., peripheral and central transmission mechanisms), stress (i.e., the HPA axis), and the autonomic nervous system (i.e., fronto-limbic and autonomic circuitry). Specifically, I want to gain the expertise to test the following three preliminary hypotheses. First, there will be differences in hypothalamic-pituitary-adrenal (HPA) axis activity (cortisol) and sensory function (detection thresholds) in children with severe neurological impairment and self-injury compared with matched controls without self-injury (between group analyses). Second: the frequency and temporal sequencing of self-injury will be correlated with HPA axis activity and sensory function (within group analyses). Third, the relation between HPA axis activity, sensory function, and SIB will change over time such that the degree of dysregulation in the former predicts increasing severity in the latter (prospective analysis). Institution and Environment Commitment: The Department of Educational Psychology and the University of Minnesota are committed to this award and provide rich resources for my career development.

描述（由申请人提供）：目标：我的研究主要涉及发育障碍患者中慢性同胞的行为机制。对SIB的病理生理学的更全面了解将需要将我们对疼痛神经生物学和压力心理生物学的丰富理解与我们对早期经历在多种疼痛和压力敏感生理系统中的作用的新了解。研究：在我的R29融资期间，我扩展了SIB的阿片类药物模型，该模型符合临床特征的一致，这些特征暗示了疼痛处理，建立了协作关系，并开始开发必要的专业知识，使我能够寻求资金来测试成人中SIB的综合疼痛和压力模型。资助的R01的目的是将与感觉功能，压力生理和疼痛行为相关的一组行为和生物学测量进行社会和非社会介导的SIB成人病例进行比较。职业计划：职业发展计划使用转化研究培训框架作为一组组织原理，以指导针对神经科学和行为遗传学新发展的研究和培训目标，整合更广泛的发展心理病理学研究计划，并扩大自我伤害研究议程以拥抱基因环境相互作用，并提高我们对个人漏洞的理解。描述了初步工作和协作关系，以支持发布时间的需求，以增强我对这些相关领域的培训和研究。该计划强调需要将自我伤害研究扩展到对小儿和神经系统研究（即疼痛调节，高风险人群），并包括在调节疼痛（即外围和中央传播机制），压力，即HPA AXIS（即HPA AXIS）以及自动神经系统（I.EBIMIMBIMIMBIC）中重要的其他系统。具体来说，我想获得专业知识来检验以下三个初步假设。首先，与没有自我伤害的匹配对照相比，患有严重神经系统损伤和自我伤害的儿童的下丘脑 - 垂体 - 肾上腺（HPA）轴活动（皮质醇）和感觉功能（检测阈值）将存在差异。第二：自我伤害的频率和时间测序将与HPA轴活动和感觉函数（在组分析中）相关。第三，HPA轴活动，感觉函数和SIB之间的关系会随着时间而变化，以使前者的失调程度预测后者的严重程度增加（前瞻性分析）。机构和环境承诺：教育心理学系和明尼苏达大学致力于该奖项，并为我的职业发展提供丰富的资源。