Text Message Physical Activity Intervention to Treat Cognitive Deficits in HIV

短信体育活动干预治疗艾滋病毒认知缺陷

• 批准号: 8743277
• 负责人: Brook Henry
• 金额: $ 19.38万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-26 至 2016-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8743277
• 关键词: AIDS neuropathy; Acquired Immunodeficiency Syndrome; Activities of Daily Living; Address; Adherence; Adverse effects; Aging; Alzheimer' s Disease; Arts; Behavior; Behavior Therapy; Body Weight decreased; California; Car Phone; Cardiopulmonary; Caring; Cognition; Cognitive; Cognitive deficits; Communication; Control Groups; Dementia; Development; Devices; Diabetes Mellitus; Diet; Disease; Electronic Mail; Electronics; Environment; Exhibits; Family; Feedback; Focus Groups; Functional disorder; Funding; Goals; HIV; HIV Infections; HIV Seropositivity; HIV risk; Health; Health Promotion; Health behavior; Image; Impaired cognition; Impairment; Incidence; Individual; Information Technology; Institutes; Intervention; Intervention Studies; Label; Life; Link; Measures; Mental disorders; Methodology; Methods; Modification; Monitor; Morbidity - disease rate; Multimedia; Neurocognitive; Neurocognitive Deficit; Neuropathy; Participant; Patient Self-Report; Performance; Persons; Pharmaceutical Preparations; Physical activity; Population; Prevalence; Protocols documentation; Public Health; Quality of life; Randomized; Randomized Controlled Trials; Reporting; Research; Research Personnel; Resources; Running; Services; Structure; Symptoms; System; Technology; Telecommunications; Text; Time; Travel; United States National Institutes of Health; Viral; Weight Gain; Wireless Technology; Work; antiretroviral therapy; base; cognitive function; cohort; design; fitness; group intervention; improved; mHealth; medication compliance; mortality; multidisciplinary; neurobehavioral; neuropsychological; novel; programs; public health relevance; service intervention; smoking cessation; social; success; theories; web site; willingness

DESCRIPTION (provided by applicant): HIV infection is frequently characterized by neurocognitive deficits collectively labeled as HIV-associated neurocognitive disorders (HAND). While the use of combination antiretroviral therapies (CART) have dramatically reduced AIDS-related morbidity, HAND remains a significant public health concern linked to impaired everyday functioning and poor quality of life in HIV-positive (HIV+) individuals. Despite the continued prevalence of HAND in the CART era, there are no empirically validated strategies to effectively treat neurocognitive dysfunction in this population. Physical activity (PA) has been utilized as an effective non- pharmacological method to improve cognitive performance in individuals with dementia and psychiatric disorders. PA interventions in HIV+ subjects are reported to improve cardiopulmonary fitness, but the effects of PA on HAND have not been well characterized. Previous HIV PA interventions also involve rigorous PA (running on a treadmill) and significant participant resources (traveling to a gym multiple times per week) that may not be suitable or practical for many HIV+ individuals. We propose to conduct a randomized controlled trial to administer a personalized interactive mobile phone text messaging intervention to increase moderate PA and improve cognitive function in HIV+ participants with HAND. This study will utilize a Short Message Service/Multimedia Message Service (SMS/MMS) platform developed by the California Institute for Telecommunications and Information Technology (Calit2), which conducts state-of-art health promotions using mobile electronic devices. 50 HIV+ participants will be randomly assigned to a control group or a 4-month intervention group that will receive daily SMS/MMS mobile phone messages designed to increase PA. The intervention condition, based on control theory, is structured to promote goal-setting by using SMS text prompts and MMS images to monitor PA, provide goal reminders, promote goal strategies, and deliver feedback on goal progress. We will conduct focus groups to identify HIV-specific PA limitations (e.g., medication side effects, neuropathy) and identify ways to overcome these barriers. Text messages will be tailored to each individual, including their social contacts and environment. We hypothesize that HIV+ participants administered this intervention will exhibit a significant increase in PA compared to a control group as assessed by pedometer step counts, accelerometer activity, and self-reported PA on the 7-Day Physical Activity Recall (PAR). Further, we propose that the intervention will improve cognitive performance and everyday functioning compared to the control condition as quantified by a comprehensive neuropsychological battery and self-report and performance-based measures of daily living activities. Findings from this proposal will lay the groundwork for development of novel large-scale personalized mobile PA interventions dedicated to treating HAND and improving the quality of life for HIV+ individuals.

描述（由申请人提供）：HIV 感染通常以神经认知缺陷为特征，统称为 HIV 相关神经认知障碍 (HAND)。虽然联合抗逆转录病毒疗法 (CART) 的使用显着降低了 AIDS 相关发病率，但 HAND 仍然是一个重大的公共卫生问题，与 HIV 阳性 (HIV+) 个体日常功能受损和生活质量差有关。尽管 CART 时代 HAND 持续流行，但尚无经过经验验证的策略来有效治疗该人群的神经认知功能障碍。体力活动（PA）已被用作 改善痴呆和精神疾病患者认知能力的有效非药物方法。据报道，对 HIV+ 受试者进行 PA 干预可以改善心肺健康，但 PA 对 HAND 的影响尚未得到很好的表征。以前的 HIV PA 干预措施还涉及严格的 PA（在跑步机上跑步）和大量的参与者资源（每周多次去健身房），这对于许多 HIV + 个体来说可能不适合或不实用。我们建议进行一项随机对照试验，以实施个性化的交互式手机短信干预，以增加 HAND 的 HIV+ 参与者的适度 PA 并改善认知功能。本研究将利用加州电信和信息技术研究所 (Calit2) 开发的短信服务/多媒体消息服务 (SMS/MMS) 平台，该平台使用移动电子设备进行最先进的健康促进。 50 名 HIV+ 参与者将被随机分配到对照组或为期 4 个月的干预组，该组将每天接收旨在增加 PA 的 SMS/MMS 手机消息。干预条件基于控制理论，通过短信文本提示和彩信图像监控PA、提供目标提醒、推进目标策略、反馈目标进度，促进目标设定。我们将开展焦点小组讨论，以确定 HIV 特异性 PA 限制（例如药物副作用、神经病变），并确定克服这些障碍的方法。短信将根据每个人量身定制，包括他们的社交联系和环境。我们假设，通过计步器步数、加速度计活动和 7 天体力活动回忆 (PAR) 中自我报告的 PA 进行评估，与对照组相比，接受此干预的 HIV+ 参与者的 PA 显着增加。此外，我们建议，与控制条件相比，干预将改善认知表现和日常功能，通过全面的神经心理学电池和自我报告以及基于日常生活活动表现的测量来量化。该提案的研究结果将为开发新型大规模个性化移动 PA 干预措施奠定基础，该干预措施致力于治疗 HAND 并改善 HIV+ 个体的生活质量。