Longitudinal Associations Between Pain and Use of Cigarettes and E-Cigarettes in the Population Assessment of Tobacco and Health (PATH) Study

烟草与健康人群评估 (PATH) 研究中疼痛与使用香烟和电子烟之间的纵向关联

• 批准号: 10312504
• 负责人: Jessica M Powers
• 金额: $ 3.52万
• 依托单位: SYRACUSE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2022-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10312504
• 关键词: Absence of pain sensation; Accounting; Acute; Address; Analgesics; Area; Award; Behavioral Sciences; Cigarette; Cigarette Smoker; Clinical; Clinical Psychology; Collaborations; Complex; Data; Data Collection; Dependence; Development; Discipline; Drug usage; Economic Burden; Educational workshop; Electronic cigarette; Etiology; Faculty; Fellowship; Female; Foundations; Frequencies; Funding; General Population; Goals; Health; High Prevalence; Individual; Intake; Interdisciplinary Study; Knowledge; Lead; Learning Skill; Link; Longitudinal Studies; Longitudinal cohort; Maintenance; Medical; Medical Care Costs; Modeling; National Institute of Drug Abuse; Nature; Neurobiology; Nicotine; Nicotine Use Disorder; Outcome; Pain; Pain intensity; Pain interference; Participant; Peptide Initiation Factors; Persons; Population Analysis; Population Assessment of Tobacco and Health; Positioning Attribute; Postdoctoral Fellow; Prevalence; Productivity; Reporting; Research; Research Personnel; Resources; Risk; Risk Factors; Self Administration; Sex Differences; Smoker; Smoking Behavior; Testing; Time; Tobacco; Tobacco Dependence; Tobacco use; Training; United States National Institutes of Health; biological sex; career; cigarette smoking; clinical practice; cohort; combustible cigarette; comorbidity; coping; economic impact; electronic cigarette use; experience; interest; male; meetings; nicotine cessation; nicotine craving; nicotine exposure; nicotine use; nicotine user; novel; pain processing; prospective; substance use; tobacco exposure; tobacco products

PROJECT SUMMARY/ABSTRACT Nicotine/tobacco use and pain are highly prevalent, frequently co-occur, and engender a substantial annual economic burden in medical costs and lost productivity.1-4 Rates of nicotine use are considerably higher among persons with co-occurring pain (vs. the general population),1, 2 and empirical studies have elucidated bidirectional associations between pain and nicotine/tobacco use/dependence. Nicotine can produce acute analgesic effects,5 and pain can be a potent motivator of nicotine/tobacco use for pain-coping.6 Furthermore, greater nicotine exposure has been linked to the development and exacerbation of pain.7-9 Despite increasing empirical focus on pain and nicotine use reciprocity, a majority of this research to date has focused solely on relations between pain and combustible cigarette smoking. Use of electronic cigarettes (e-cigarettes) has drastically increased over the past decade,10, 11 co-use of cigarettes and e-cigarettes is increasingly common,12 and individuals with pain may be uniquely at risk for initiation and escalation of use/co-use of e-cigarettes and cigarettes.13-15 Therefore, the goal of this proposal is to conduct the first longitudinal study of pain and use/co- use of e-cigarettes and tobacco cigarettes utilizing four waves of nationally representative cohort data collected for the Population Assessment of Tobacco and Health (PATH) Study.16 First, the proposed study will assess whether smokers with co-occurring pain (vs. no/low pain) are more likely to initiate co-use of e-cigarettes. Second, pain will be examined as a prospective predictor of (a) likelihood of cigarette and e-cigarette use/co- use, and (b) trajectories of use/co-use over time. It is hypothesized that individuals with pain will be more likely to use e-cigarettes and/or cigarettes and will increase frequency and heaviness of use across all four waves. Finally, biological sex will be examined as a moderator of the hypothesized relationships, given known sex differences in both the experience of pain and nicotine consumption. Completion of this project may advance research and clinical practice by establishing pain as a significant, yet under-recognized risk factor in the onset and escalation of nicotine consumption (via cigarettes and/or e-cigarettes). This proposal is consistent with NIDA’s stated goal of understanding the complex interactions of factors, such as medical comorbidities, that influence drug use trajectories.17 This award would provide resources and protected time to further the applicant’s training in several key areas, including increasing knowledge of pain and use of alternative nicotine/tobacco products and learning skills relevant to analysis of population-level data and trajectory modeling. The trainings, workshops, and collaborations necessary to complete the proposed project aims would be otherwise unavailable through the applicant’s clinical psychology graduate studies and placement requirements. The applicant is committed to pursuing a career as an independent NIH-funded researcher, and aims to obtain a post-doctoral fellowship and subsequent faculty position that will allow her to pursue a programmatic line of multidisciplinary research in the rapidly emerging domain of pain and substance use.

项目摘要/摘要 尼古丁/烟草的使用和疼痛非常普遍，经常同时发生，并引起大量年度 经济燃烧的医疗成本和生产力降低。1-4尼古丁使用率较高 同时发生疼痛的人（与一般人群），1、2和经验研究已经阐明了 疼痛与尼古丁/烟草使用/依赖性之间的双向关联。尼古丁会产生急性 止痛作用，5和疼痛可能是尼古丁/烟草使用止痛的潜在基序。6此外，此外， 尼古丁的暴露与疼痛的发展和加剧有关。7-9尽管增加了 对疼痛和尼古丁使用互惠的经验关注，迄今为止的大多数研究仅关注 疼痛与吸烟混合之间的关系。使用电子烟（电子烟）具有 在过去的十年中，大幅增长，越来越普遍，10，11共同使用香烟和电子烟是12 疼痛的人可能有唯一的风险和使用/共同使用电子烟的倡议和升级 13-15因此，该提案的目的是进行疼痛和使用/共同的纵向研究 利用四波全国代表性同类数据的波浪使用电子烟和烟草香烟 对于烟草和健康（PATH）研究的人口评估。16首先，拟议的研究将评估 同时发生疼痛的吸烟者是否更有可能引发电子烟的共同使用。 其次，将检查疼痛作为（a）香烟和电子烟的可能性的前瞻性预测指标。 使用，（b）随着时间的推移使用/共用的轨迹。假设疼痛的人更有可能 使用电子烟和/或香烟，并将在所有四个波浪中增加使用频率和天堂。 最后，鉴于已知的性别 疼痛和尼古丁消耗的经历的差异。该项目的完成可能会进步 研究和临床实践通过确定疼痛为发作中的重要但被识别的危险因素 以及尼古丁消耗的升级（通过香烟和/或电子烟）。该提议与 NIDA陈述了了解因素的复杂相互作用，例如医学合并症， 影响毒品使用轨迹。17该奖项将提供资源和受保护的时间，以促进 申请人在几个关键领域的培训，包括增加疼痛知识和替代方案的使用 尼古丁/烟草产品和学习技能与人口级数据和轨迹分析有关 造型。完成拟议项目的目标所需的培训，研讨会和合作 否则，申请人的临床心理学研究生学习和安排将无法获得 要求。适用的人致力于从事独立NIH资助的研究人员的职业，并且 旨在获得博士后奖学金和随后的教师职位，这将使她能够追求 在快速新兴的疼痛和药物使用领域中，多学科研究的编程线。