BioPAX - Biological Pathway Community Workshop

BioPAX - 生物途径社区研讨会

• 批准号: 7168021
• 负责人: CHRIS SANDER
• 金额: $ 1万
• 依托单位: SLOAN-KETTERING INST CAN RESEARCH
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-01-10 至 2008-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7168021
• 关键词: Adopted; Adoption; Alcohols; Binding; Biological; Biological Models; Biological Process; Biology; Class; Communities; Community Developments; Community Participation; Computer software; DNA; Data; Databases; Development; Educational workshop; Fees; Funding; Future; Genbank; Gene Expression Regulation; Generic Drugs; Genes; Genetic; Genetic Epistasis; Genus Mentha; Goals; Growth; Imagery; Information Systems; Language; Lead; Licensing; Location; Maps; Memorial Sloan-Kettering Cancer Center; Metabolic Pathway; Modeling; Molecular; National Institute of General Medical Sciences; New York; Participant; Pathway interactions; Phosphotransferases; Post-Translational Protein Processing; Problem Solving; Process; Research; Resources; Series; Signal Pathway; Signaling Pathway Gene; Software Tools; Standards of Weights and Measures; System; Systems Biology; Time; Training; Wit; Work; base; biological research; cost; data integration; data modeling; day; interest; mathematical model; member; news; open source; symposium; tool; transcription factor

DESCRIPTION (provided by applicant) Pathway information is vital for understanding biological systems. Unfortunately, the over 170 online pathway data resources vary widely in coverage and representation of biological processes, making their use for biological problem solving extremely difficult. The BioPAX group was formed by the pathway database community in November 2002 to develop a standard biological pathway data exchange format to solve this issue through a series of small workshops. This has resulted in the development of the community accepted, open-source BioPAX level 1 exchange format, which supports metabolic pathway data and BioPAX level 2, which adds support for molecular interaction data. We seek support for a workshop series for the years 2006, 2007 and 2008. The goals of this meeting series are to expand the BioPAX data model by adding support for signaling pathways, gene regulation networks and genetic interactions, such as epistasis; to increase database and tool support for.BioPAX; and to encourage the growth of publicly accessible pathway data and its application to biological problems. We propose to hold BioPAX workshops twice a year, each lasting two days. These will focus on achieving our goals through BioPAX data model and community development discussions. One workshop per year will include a symposium of invited speakers discussing their pathway related computational research. Meetings will include a hackathon, where computer software, such as database converters, is collaboratively developed. Meetings will be hosted by participants and locations will cycle through SRI, Menlo Park, CA (Peter Karp), Cold Spring Harbor Labs, New York, NY (Lincoln Stein) and Memorial-Sloan Kettering Cancer Center, New York, NY (Chris Sander) or other convenient US locations. All meetings will be open to community participation and all minutes and resulting work is freely available under open source terms via the www.biopax.org website.

描述（由申请人提供）途径信息对于理解生物系统至关重要。不幸的是，超过170个在线途径数据资源在覆盖和代表生物过程中差异很大，这使得它们用于生物问题解决非常困难。 Biopax组是由Pathway数据库社区于2002年11月成立的，以开发标准的生物途径数据交换格式，以通过一系列小型研讨会来解决此问题。这导致了社区接受的开源Biopax 1级交换格式的发展，该格式支持代谢途径数据和Biopax级别2，这增加了对分子交互数据的支持。我们寻求对2006年，2007年和2008年的研讨会系列的支持。该会议系列的目标是通过增加对信号途径，基因调节网络和遗传相互作用（例如epitipis）的支持来扩展Biopax数据模型；增加数据库和工具支持。并鼓励公开访问的途径数据及其在生物学问题上的应用。我们建议每年两次举办Biopax研讨会，每年持续两天。这些将着重于通过Biopax数据模型和社区发展讨论来实现我们的目标。每年一个研讨会将包括一组邀请的演讲者，讨论他们的途径相关计算研究。会议将包括一场黑客马拉松，其中计算机软件（例如数据库转换器）是协作开发的。会议将由参与者举办，地点将循环通过SRI，加利福尼亚州门洛公园（Peter Karp），纽约，纽约，林肯·斯坦（Lincoln Stein）（林肯·斯坦（Lincoln Stein））和纽约州纽约，纽约州纽约（Chris Sander）或其他便利的美国地区的纪念苏朗克斯特林癌症中心。所有会议将开放社区参与，所有会议记录和由此产生的工作均可通过www.biopax.org网站在开源条款下免费获得。