Pathway Commons: Research Resource for Biological Pathways

Pathway Commons：生物途径研究资源

• 批准号: 8935277
• 负责人: CHRIS SANDER
• 金额: $ 60.72万
• 依托单位: SLOAN-KETTERING INST CAN RESEARCH
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-22 至 2015-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8935277
• 关键词: Automobile Driving; Behavior; Big Data; Biological; Biological Process; Biology; Cells; Collaborations; Communication; Communities; Community Healthcare; Computer software; Data; Data Aggregation; Data Analyses; Data Set; Databases; Development; Diagnosis; Ecosystem; Elements; Explosion; Feeds; Funding; Genetic Variation; Genomics; Health; Hereditary Disease; Human Genetics; Incentives; Internet; Knowledge; Language; Link; Maps; Medicine; Modeling; Molecular; National Human Genome Research Institute; Pathway Analysis; Pathway interactions; Patients; Process; Provider; Research; Research Infrastructure; Research Personnel; Resource Informatics; Resources; Scheme; Science; Services; Software Tools; Source; Speed; Staging; System; Technology; Time; Training; Training Support; Translating; United States National Institutes of Health; Vision; Work; base; biological systems; citizen science; computerized tools; cost effective; data exchange; design; flexibility; genome-wide; human genome sequencing; improved; indexing; next generation; novel; open source; predictive modeling; public health relevance; research study; tool; web services

 DESCRIPTION (provided by applicant): Biological pathways represent knowledge about molecules, processes and their interactions. Maps of such pathways are used to design and analyze experiments, and for predicting the behavior of biological systems. Pathway information is extremely difficult for biologists to use in its current fragmented and incomplete state, involving a large amount of time and effort to wade through, piece together and analyze. The Pathway Commons research resource is being developed to overcome this roadblock by providing researchers with a convenient single point of access to diverse biological pathway information translated to a common data language. This project is an important step towards the development of a complete and integrated computable map of the cell across all species and developmental stages. Pathway Commons promotes and supports convergence, by the community, to a truly integrated computable and searchable representation of cellular biological processes. Pathway Commons does not compete with or duplicate efforts of pathway databases or software tool providers. Existing database groups provide pathway curation, while Pathway Commons provides mechanism and technology for adding value, disseminating, and reducing duplication of effort. Collaboration with user and database groups is a central component, driven by the desire for maximum synergy and efficiency. The Pathway Commons resource will aggregate datasets from multiple major pathway databases; translate, store, validate, index, integrate, hyperlink and maintain the information for maximum quality access; freely deliver pathway information to the scientific public, both academic and commercial, using advanced internet technology; and, provide open-source end user software for pathway browsing and analysis. User support and training for Pathway Commons and related resources will be freely available to the scientific community.

 描述（适用提供）：生物途径代表有关分子，过程及其相互作用的知识。这种途径的地图用于设计和分析实验，并预测生物系统的行为。途径信息对于生物学家目前的零散且不完整的状态非常困难，涉及大量的时间和精力来涉水，拼凑并进行分析。正在开发Commons研究资源，以克服这一障碍，通过为研究人员提供便利的单点访问潜水员生物途径信息，转化为通用数据语言。该项目是迈向在所有物种和发育阶段开发完整和集成的可计算图的重要一步。通道共享促进和支持社区的融合，以真正集成的可计算和可搜索的细胞生物过程表示。通道Commons不会与Pathway数据库或软件工具提供商的竞争或重复努力。现有的数据库组提供途径策划，而通道Commons为增加价值，传播和减少努力重复的机制和技术提供了机制和技术。与用户和数据库组的协作是一个核心组成部分，这是对最大程度的协同作用和效率的愿望驱动的。路径CONSONS资源将从多个主要路径数据库中汇总数据集；翻译，存储，验证，索引，集成，超链接并维护信息，以最大程度地访问质量；使用先进的互联网技术向科学公众提供免费送货途径信息；并且，提供开源的最终用户软件以浏览和分析。科学界将免费获得通路和相关资源的用户支持和培训。