The Connie Wofsy Women's HIV Study

康妮·沃夫西女性艾滋病毒研究

基本信息

批准号：
7188647
负责人：
RUTH Martha GREENBLATT
金额：
$ 305.6万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
1993
资助国家：
美国
起止时间：
1993-08-01 至 2007-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7188647
关键词：
AIDS and Cancer Specimen Bank AIDS clinical trial group AIDS prevention AIDS related cancer Abdomen Accession Number Acetone Acquired Immunodeficiency Syndrome Acute Address Adherence Administrator Advisory Committees Affect Alcohol consumption Aliquot Anemia Annual Reports Anti-Retroviral Agents Anus Appendix Applications Grants Appointment Area Attention Authorization documentation Award Back Bacteria Bacterial Vaginosis Behavioral Biology Biopsy Blood Blood Cells Blood specimen Boxing Breast Businesses CD4 Lymphocyte Count CD8-Positive T-Lymphocytes California Candidiasis Caring Carpet Catheters Cell Count Central obesity Cervical Cervical dysplasia Cessation of life Chairperson Characteristics Chicago Child Care Chronic Clinic Clinical Clinical Data Clinical Management Code Cohort Studies Collaborations Collection Colposcopy Communicable Diseases Communities Community Outreach Computer Analysis Computers Concept Review Condition Consent Consult Consultations Corpus Luteum Cyst Coulter counter Counseling County Curette DNA Daily Data Data Collection Data Set Database Management Systems Databases Date of birth Dental Dental caries Deposition Dermatologist Dermatology Development Devices Diagnosis Diagnostic tests Director&apos s Working Group Disease Disruption District of Columbia Dose Drops Drug Industry Drug Kinetics Dry Ice Dysplasia Educational Activities Educational process of instructing Endocrinologist Endocrinology Enrollment Ensure Epidemiology Equipment and supply inventories Event Excision Faculty Failure Fatty Liver Fatty acid glycerol esters Feedback Fellowship Fertility Fibrosis Financial compensation Follow-Up Studies Food Foundations Freezing Frequencies Funding Future Gays Gender General Hospitals Genotype Gifts Gingiva Gland Goals Gonadal Steroid Hormones Grant Group Meetings Gynecology HIV HIV Infections HIV Seropositivity Hair Hand Health Health care facility Hemorrhage Hepatic Hepatitis B Hepatitis C Hepatitis C virus Hepatotoxicity Highly Active Antiretroviral Therapy Holidays Home environment Hospitals Hour Household Housing Human Herpesvirus 8 Human Papillomavirus Human Resources Human immunodeficiency virus test Hyperglycemia Image Immunologics Immunology Incentives Incidence Individual Infection Informed Consent Inpatients Institutes Institution Instruction Insulin Resistance International International AIDS Interview Interviewer Intravenous K-Series Research Career Programs Label Laboratories Laboratory Finding Lactic Acidosis Language Lead Leadership Learning Left Lesion Letters Licensing Life Link Lipoatrophy Lipodystrophy Liquid substance Liver Liver Fibrosis Liver diseases Location Los Angeles Lymphocyte Subset MRI Scans Maiden Name Mails Malignant Neoplasms Manuals Measurement Measures Medical Medical Records Medical Surveillance Medical center Menstrual cycle Menstrual fluid Menstruation Metabolic Methodology Methods Microscope Mitochondrial Carnitine Palmitoyltransferase Pathway Modeling Modification Monitor Morbidity - disease rate Names National Cancer Advisory Board National Institute of Child Health and Human Development National Institute of Diabetes and Digestive and Kidney Diseases Natural History Needlestick Injuries New York Newsletter Nitrogen Notification Numbers Nurse Practitioners Obesity Occupational Safety Online Systems Operative Surgical Procedures Opportunistic Infections Oral Oral Manifestations Oral Medicine Oral candidiasis Oral mucous membrane structure Outcome Outpatients Ovarian Follicle Pain Panic Paper Participant Pathologist Pathology Patient Self-Report Patients Pattern Pelvic Examination Periodontal Diseases Peripheral Peripheral Blood Mononuclear Cell Pharmaceutical Preparations Pharmacologic Substance Phase Pilot Projects Placement Plasma Play Policies Population Portraits Pre-Post Tests Premalignant Prevalence Primary Health Care Principal Investigator Printing Privacy Problem Solving Procedures Process Professional counselor Prospective Studies Protocols documentation Provider Public Health Publications Puncture biopsy Purpose Qualifying Quality Control Questionnaires RNA Randomized Randomized Controlled Trials Rate Reading Recommendation Recording of previous events Recruitment Activity Registries Regulation Reporting Reproductive Endocrinology Research Research Design Research Infrastructure Research Methodology Research Personnel Resistance Resources Rewards Risk Risk Factors Roentgen Rays Role Running Safety Saliva Salivary Salivary Gland Diseases Salivary Glands Sampling San Francisco Scanning Schedule Scientist Sentinel Series Serum Services Severities Shipping Ships Shortness of Breath Site Slide Smoke Social Conditions Social Security Number Social Work Source Spain Specific qualifier value Specimen Specimen Handling Speed Sterilization for infection control Structure Summary Reports Survivors Swab System Techniques Telephone Telephone Number Temperature Testing Time Tissue Donations Tissue Sample Tissues To specify Toxic effect Training Transportation Travel Treatment Protocols Triage Tube Tuberculosis Ultrasonography United States United States Department of Veterans Affairs United States National Institutes of Health Universities Update Urine Vagina Vaginal Douching Venous Vial device Viral Viral Load result Virus Visceral Visit Week Withdrawal Woman Women&apos s Health Work Workplace Writing X-Ray Computed Tomography analog base blind chemokine receptor clinical research site clinically relevant cohort cold temperature community organizations community planning comparative comparison group computer generated computerized concept cost data management day design drug testing experience falls follow-up health care referral health care service utilization housing instability hydroxyurea improved indexing innovation insight instrument interest liver biopsy liver imaging malignant breast neoplasm member men milliliter mutant non-nucleoside reverse transcriptase inhibitors nucleoside analog oral lesion organizational structure parole physical abuse post-doctoral training preference prevent probation programs proliferative phase Menstrual cycle prospective psychosocial receptor density repository reproductive research facility research study sample collection satisfaction sex social statistics success symposium tertiary care tool trait trend virology

项目摘要

DESCRIPTION ( provided by applicant) This application for the Northern California WIHS site (the Connie Wofsy Women's HIV Study -- CWWHS) is divided into three sections, as per RFA instructions. The first section reports the contributions of our site to the WIHS progress, including cohort and sub study recruitment and retention, scientific leadership, and contributions to organizational leadership. This section contain several standardized tables (the numbers were provided by WDMAC) as well as a table summarizing the activities at our site. The second section provides methods for the research proposed for WIHS III (scientific rationale discussed in Part A). This section provides methods for retention of participants, incorporations of WIHS III protocol modifications, site structure and scientific leadership. The third section describes a proposal for a pilot study of hepatic steatosis among the CWWHS participants. This study, proposed by site investigators Phyllis Tien and Carl Grunfeld and two UCSF-based hepatologists, Norah Terrault and Teresa Wright, defines the incidence and prevalence of hepatic steatosis (HS) among HCV-infected women and factors associated with HS, such as obesity, body habitus changes (defined using DXA imaging) and nucleoside analog therapy. This study will also evaluate the accuracy of computerized tomography in detecting HS compared with percutaneous needle biopsy. This pilot project will also provide insight into the feasibility of this kind of intensive sub study in WIHS. The WIHS III will also provide us with the opportunity to work with new UCSF investigators. In addition to those listed above, this proposal introduces Lewis Sheiner and Joseph Guglielmo (clinical pharmacologists) into the treatment exposure and resistance team and Robert Taylor (reproductive endocrinologist) to the new WIHS initiative on sex steroids. Overall, we are delighted to have this opportunity to propose continued work with the WIHS cohort, which we believe can provide unique and important findings on a representative group of HIV -infected and at-risk women in the United States.

说明（由申请人提供）根据 RFA 说明，北加州 WIHS 网站（康妮·沃夫西妇女艾滋病毒研究 - CWWHS）的申请分为三个部分。第一部分报告了我们网站对 WIHS 进展的贡献，包括队列和子研究的招募和保留、科学领导力以及对组织领导力的贡献。本节包含几个标准化表格（数字由 WDMAC 提供）以及一个总结我们站点活动的表格。第二部分提供了 WIHS III 拟议研究的方法（科学原理在 A 部分中讨论）。本节提供了保留参与者、纳入 WIHS III 协议修改、站点结构和科学领导力的方法。第三部分描述了在 CWWHS 参与者中进行肝脂肪变性试点研究的提案。这项研究由现场调查员 Phyllis Tien 和 Carl Grunfeld 以及加州大学旧金山分校的两位肝病学家 Norah Terrault 和 Teresa Wright 提出，定义了 HCV 感染女性中肝脂肪变性 (HS) 的发病率和患病率以及与 HS 相关的因素，例如肥胖、身体形态改变（使用 DXA 成像定义）和核苷类似物治疗。本研究还将评估计算机断层扫描与经皮穿刺活检相比检测 HS 的准确性。该试点项目还将深入探讨 WIHS 中此类强化子研究的可行性。 WIHS III 还将为我们提供与新的 UCSF 研究人员合作的机会。除了上面列出的之外，该提案还将 Lewis Sheiner 和 Joseph Guglielmo（临床药理学家）引入治疗暴露和耐药团队，并将 Robert Taylor（生殖内分泌学家）引入关于性类固醇的新 WIHS 倡议。总的来说，我们很高兴有这个机会建议继续与 WIHS 队列合作，我们相信这可以为美国艾滋病毒感染者和高危女性的代表性群体提供独特而重要的发现。