NICHD Maternal Fetal Medicine Units Network

NICHD 母胎医学单位网络

基本信息

批准号：
7220074
负责人：
RONALD WAPNER
金额：
$ 191.24万
依托单位：
COLUMBIA UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2001
资助国家：
美国
起止时间：
2001-04-01 至 2011-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7220074
关键词：
AIDS clinical trial group Academic Medical Centers Address Adherence Admission activity Adoption Adrenal Cortex Hormones Affect Alabama Ambulatory Care American Medical Association Amniocentesis Ancillary Study Aneuploidy Antioxidants Appendix Area Australia Award Basal cell carcinoma Basic Science Bed rest Betamethasone Biochemistry Biology Biometry Blood Blood Circulation Blood Urea Nitrogen Blood urea nitrogen measurement Boston CRH gene Canada Cardiac Caring Carmustine/Cytarabine/Etoposide/Melphalan Cells Cephalic Cervical Cervical Cerclage Cervical Ripening Cervix Uteri Cesarean section Chairperson Child Childhood Chorionic Villi Sampling Classification Clinic Clinical Clinical Investigator Clinical Research Clinical Services Clinical Treatment Clinical Trials Collection Commit Communicable Diseases Community Hospitals Complement Computerized Patient Records Condition Conflict (Psychology)Congenital Abnormality Consensus Contracts Corticotropin-Releasing Hormone Counseling Daily Data Data Analyses Data Quality Databases Delivery Rooms Development Discipline of obstetrics Doctor of Medicine Doctor of Philosophy Down Syndrome Early Diagnosis Educational process of instructing Electronics Eligibility Determination Emerging Technologies Endocrine Endocrinologist Enrollment Environment Epidemiologist Europe Evaluation Faculty Fetofetal Transfusion First Pregnancy Trimester Follow-Up Studies Funding Gases Generic Drugs Genetic Genetic Determinism Genotype Geographic Information Systems Gestational Diabetes Glucose Goals Grant Guidelines Gynecology HIV Health Insurance Portability and Accountability Act High Risk Woman Home environment Home visitation Hospitals Hour House Call Hydroxyprogesterone Caproate Immunologist Individual Infant Infection Inflammation Injection of therapeutic agent Inorganic Sulfates Inpatients Institution International Intervention Intravenous Immunoglobulins Invasive Investigation Ireland Journals Laboratories Lead Leadership Letters Location Magnesium Manuals Manuscripts Medical Records Medical Surveillance Medical center Medicine Meningomyelocele Mental Depression Methods Mission Modality Modification Monitor Morbidity - disease rate Mosaicism Mucous body substance Multicenter Studies Multicenter Trials Names National Institute of Allergy and Infectious Disease National Institute of Child Health and Human Development Neonatal Neonatology New England New York Newsletter None or Not Applicable Nuchal Translucency Nuchal Translucency Measurement Numbers Nurses Nursing Research OGTT Observational Study Obstetrics Departments Omega-3 Fatty Acids Operative Surgical Procedures Outcome Outpatients Paper Participant Patient Recruitments Patient currently pregnant Patients Pediatric Hospitals Pennsylvania Performance Perinatal Perinatal Epidemiology Periodontal Diseases Pessaries Pharmacology Phase Philadelphia Physicians Placebos Play Policies Population Population Heterogeneity Population Study Positioning Attribute Pre-Eclampsia Pregnancy Pregnancy Outcome Premature Birth Premature Labor Prematurity of fetus Prenatal Diagnosis Prenatal care Preparation Prevention Principal Investigator Printing Privacy Probability Procedures Process Productivity Progesterone Progress Reports Prostaglandins Protocols documentation Public Health Publications Publishing Pulse Oximetry Randomized Randomized Clinical Trials Randomized Controlled Clinical Trials Rate Recording of previous events Recruitment Activity Registries Reporting Reproductive Health Research Research Design Research Ethics Committees Research Infrastructure Research Personnel Resolution Resources Retrieval Risk Role Safety Sample Size Sampling Schedule Scientist Screening procedure Second Pregnancy Trimester Sentinel Serum Services Site Specialist Specimen Standards of Weights and Measures Steroids Supplementation Support System Surveys Telephone Testing Therapeutic Thrombocytopenia Thyroid Gland Time Tocolysis Training Travel Treatment Protocols Triage Twin Multiple Birth Ultrasonography Umbilical cord structure United States National Institutes of Health Universities Unspecified or Sulfate Ion Sulfates Upper arm Uterine Monitoring Vagina Vaginal Birth after Cesarean Variant Visit Week Woman Women&apos s Health Work Writing Zidovudine base clinical efficacy cohort college compliance behavior concept congenital heart disorder controlled release data management day design experience fetal fetal diagnosis fetus cell follow-up forest hazard health literacy improved member microorganism mortality neonatal morbidity new technology nutrition pediatrician prenatal prevent programs prospective protocol development randomized placebo controlled trial receptor response skills smoking cessation social success symposium transmission process trophoblast volunteer

项目摘要

DESCRIPTION (provided by applicant): Columbia University has been an active contributor to the MFMU since 2001 and is now submitting a competitive renewal. They presently are ranked fourth overall in participation and have routinely recruited in the top half of all centers. Since the last application, the Division has grown to 17 MFM specialists, 10 of which are available to the network; all of whom have protected research time. The faculty have extensive experience in multicentered collaborative research; including protocol design and analysis. Ronald Wapner, MD has been recruited to be the PI of this application. He was previously PI at both Drexel and Thomas Jefferson University. Under his direction these sites routinely ranked among the top 5 centers. Drexel is presently ranked second. A concept evaluating the relationship of maternal genotype to preterm birth has been developed and demonstrates the center's capabilities at protocol development and their understanding of the value of a large collaborative network. This trial specifically evaluates variations in the (32adrenergic receptor and the impact on preterm birth and the response to tocolysis. Interactions between other genotypes suggested to increase preterm birth and specific demographic and environmental variables will be evaluated. olumbia has the research infrastructure to be successful as a participant in the MFMU which includes experienced research nurses, a perinatal database, and a delivery service of over 6000 deliveries/yr in a single institution. Additional resources available include perinatal epidemiology, basic science expertise, and :ormal relationships with community hospitals providing access to additional patients if and when necessary.

描述（由申请人提供）：哥伦比亚大学自 2001 年以来一直是 MFMU 的积极贡献者，目前正在提交竞争性更新。目前，他们的参与度总体排名第四，并且通常在所有中心的前半部分进行招募。自上次申请以来，该部门已拥有 17 名 MFM 专家，其中 10 名可用于网络；他们所有人都保护了研究时间。教师具有丰富的多中心合作研究经验；包括协议设计和分析。 Ronald Wapner 医学博士已被聘为该应用程序的 PI。他之前曾担任德雷克塞尔大学和托马斯杰斐逊大学的 PI。在他的指导下，这些网站经常跻身前 5 名中心之列。德雷塞尔目前排名第二。评估母亲基因型与早产关系的概念已经开发出来，并展示了该中心在方案开发方面的能力以及他们对大型协作网络价值的理解。该试验专门评估（32肾上腺素能受体）的变化以及对早产的影响以及对安胎的反应。将评估建议增加早产的其他基因型与特定人口和环境变量之间的相互作用。哥伦比亚拥有成功的研究基础设施，因为MFMU 的参与者，其中包括经验丰富的研究护士、围产期数据库以及单个机构每年超过 6000 次分娩的分娩服务其他可用资源包括围产期。流行病学、基础科学专业知识以及：与社区医院的正式关系，以便在必要时接触更多患者。