Prevention of Preterm Birth in high Risk Nulliparous Patients

高危未产妇早产的预防

• 批准号: 8602022
• 负责人: RONALD WAPNER
• 金额: $ 35.8万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-01-10 至 2014-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8602022
• 关键词: Birth; Characteristics; Clinical; Clinical Research; Clinical Trials Cooperative Group; Coupled; Demographic Factors; Development; Discipline of obstetrics; Environmental Exposure; Epigenetic Process; Fetal Mortality Statistics; Fetus; Genetic; Genotype; Growth; Healthcare Systems; Incidence; Inflammatory; Intervention; Lead; Morbidity - disease rate; Participant; Pathology; Pathway interactions; Patients; Physiological; Placentation; Population; Pregnancy; Pregnancy Outcome; Pregnant Women; Premature Birth; Prevention; Public Health; Relative (related person); Research Infrastructure; Risk; Risk Factors; Role; Term Birth; Ultrasonography; Universities; Woman; cytokine; fetal; fetal medicine; genetic epidemiology; high risk; premature; public health relevance; response

DESCRIPTION: Columbia University's Division of Maternal Fetal Medicine has an active and successful clinical research infrastructure. Coupled with this infrastructure is a large obstetrical population. They have made major contributions to multiple multicentered clinical trial groups including the Maternal Fetal Medicine Network. They are now applying along with Christiana Care Health Systems, Inc. for participation in the Nulliparous Network. Ronald Wapner, MD has a superior record of clinical research participation and will be the PI of this application. This center offers not only the clinical attributes required to be a successful participant but also brings the Network exceptional expertise in public health, epidemiology, genetics and epigenetics, placental pathology, and ultrasound. A concept proposal describing the development of an algorhithim to quantify preterm birth risk in nulliparous patients is provided. This study specifically evaluates the impact of the maternal and fetal inflammatory/infectious pathway on preterm birth and investigates the relative role and interactions between genotype, ethnic, cytokine levels, environmental exposures, and demographic factors suggested to increase preterm birth.

描述：哥伦比亚大学孕产妇医学部具有积极而成功的临床研究基础设施。加上该基础设施是大量的产科人口。他们为包括母体胎儿医学网络在内的多个多中心临床试验组做出了重大贡献。他们现在正在与Christiana Care Health Systems，Inc。一起申请参加无效网络。医学博士Ronald Wapner拥有临床研究参与的较高记录，并且将成为该应用程序的PI。该中心不仅提供成功参与者所需的临床属性，而且还提供了公共卫生，流行病学，遗传学和表观遗传学，胎盘病理学和超声波的网络专业知识。提供了一项描述算法发展以量化无效患者早产风险的概念建议。这项研究专门评估了孕产妇和胎儿炎症/感染途径对早产的影响，并研究了基因型，种族，细胞因子水平，环境暴露和人口统计学因素之间的相对作用和相互作用，并建议增加早产。