Methylation patterns in colorectal cancer

结直肠癌的甲基化模式

• 批准号: 7282091
• 负责人: LAURA ROZEK
• 金额: $ 5.04万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-01 至 2008-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7282091
• 关键词: Address; Case-Control Studies; Characteristics; Cluster Analysis; Colorectal; Colorectal Cancer; CpG Islands; DNA Methylation; Diagnosis; Epigenetic Process; Fellowship; Gene Silencing; General Population; Genes; Genetic; Goals; Hereditary Nonpolyposis Colorectal Neoplasms; Hypermethylation; Individual; Israel; Lead; Link; Literature; MLH1 gene; MSH2 gene; Malignant Neoplasms; Measures; Methylation; Microsatellite Repeats; Mismatch Repair; Molecular; Molecular Epidemiology; Mutation; Names; Pathologic; Pathway interactions; Pattern; Phenotype; Population; Prevalence; Prognostic Factor; Promoter Regions; Registries; Reporting; Research; Sampling; Severity of illness; Subgroup; Syndrome; TP53 gene; Thinking; Tumor Suppressor Genes; Tumor-Suppressor Gene Inactivation; Vital Statistics; base; carcinogenesis; gene repression; novel; prognostic; tumor

DESCRIPTION (provided by applicant): Here, I propose to use the Molecular Epidemiology of Colorectal Cancer (MECC) study, a large population-based case-control study of colorectal cancer in northern Israel, to investigate methylation status in colorectal cancer. The overall hypothesis of this proposal is that methylation status represents a distinct group of CRCs that may independently predict overall survival from CRC. Specifically, the goals are to: 1. Measure the prevalence of hypermethyled genes in sporadic CRC by comparing the methylation panel on available tumor and normal samples (approximately 1450 paired samples) from MECC cases; 2. Determine if patterns of hypermethylation represent distinct subgroups of CRC; 3. Evaluate hypermethylation as an independent prognostic factor in CRC: a. Using Israeli national registries and vital statistics compare survival in subjects; b. Measure survival in the presence of other classically reported prognostic factors. This research addresses the question of whether methylation status defines a subset of tumors with distinct genetic, epigenetic and clinicopathologic characteristics in the general population.

描述（由申请人提供）：在这里，我建议利用结直肠癌分子流行病学（MECC）研究，一项以色列北部结直肠癌的大规模人群病例对照研究，来调查结直肠癌的甲基化状态。该提议的总体假设是甲基化状态代表一组不同的 CRC，可以独立预测 CRC 的总体生存率。具体来说，目标是： 1. 通过比较来自 MECC 病例的可用肿瘤和正常样本（约 1450 个配对样本）的甲基化组，测量散发性 CRC 中高甲基化基因的患病率； 2. 确定高甲基化模式是否代表 CRC 的不同亚组； 3. 将高甲基化作为 CRC 的独立预后因素进行评估： 一个。使用以色列国家登记处和生命统计数据比较受试者的生存情况； b.在存在其他经典报告的预后因素的情况下测量生存率。 这项研究解决了甲基化状态是否定义了一般人群中具有独特遗传、表观遗传和临床病理特征的肿瘤子集的问题。