Synaptic plasticity in the medial superior olive

内侧上橄榄突触可塑性

• 批准号: 7234373
• 负责人: LUISA L SCOTT
• 金额: $ 4.14万
• 依托单位: UNIVERSITY OF TEXAS AT AUSTIN
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-15 至 2008-03-01
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7234373
• 关键词: Action Potentials; Amplifiers; Attenuated; Auditory; Axon; Brain Stem; Cells; Code; Cues; Dendrites; Development; Ear; Electrophysiology (science); Face; Fellowship; Fire - disasters; Frequencies; Generations; Grant; Hearing; Immunohistochemistry; Individual; Ion Channel; Kinetics; Location; Medial; Mediating; Membrane; Monitor; Morphology; Myelin; Names; Neurons; Olives - dietary; Pathway interactions; Pharmaceutical Preparations; Phase; Physiological; Play; Potassium Channel; Property; Range; Rate; Role; Signal Transduction; Site; Slice; Sodium; Sodium Channel; Somatic Cell; Sound Localization; Staining method; Stains; Structure; Synapses; Synaptic plasticity; Techniques; Testing; Time; Training; Week; Whole-Cell Recordings; Work; attenuation; auditory stimulus; density; electrical property; neuronal cell body; physical separation; research study; segregation; sound; voltage clamp; voltage gated channel

DESCRIPTION (provided by applicant): Principal neurons of the medial superior olive (MSO) compute sound location from interaural time disparities (ITDs) introduced by the physical separation of the ears. In turn, they encode horizontal sound location in their rate of action potential (AP) firing. It is not fully understood how MSO neurons' intrinsic electrical properties combine with their highly structured morphology (ie., channel expression/distribution) to support this submillisecond computation, particularly in the face of high frequency firing found in auditory brainstem pathways. Recent work shows AP backpropagation into the soma and dendrites is downregulated developmentally such that somatic APs are small in electrically mature neurons. Experiments in this grant will explore the mechanisms and functional significance for the electrical segregation of AP signaling from synaptic integration using immunohistochemistry and slice electrophysiology techniques. Results will uncover how the membrane properties of MSO neurons help to surmount the unique computational challenges associated with encoding brief sound localization cues embedded in high frequency signals.

描述（由申请人提供）：内侧上级橄榄（MSO）计算的主神经元，从耳间差异（ITD）通过耳朵的物理分离引入。反过来，它们在动作电位（AP）射击中编码水平声音位置。尚不完全了解MSO神经元的固有电性能与它们的高度结构形态（即通道表达/分布）相结合，以支持这一亚数计算，尤其是面对听觉脑干途径中的高频射击。最近的工作表明AP向后传播到SOMA中，树突在发育上被下调，因此体内成熟神经元中的体细胞AP很小。该赠款中的实验将探讨使用免疫组织化学和切片电生理学技术从突触整合中AP信号的电分离的机制和功能意义。结果将发现MSO神经元的膜特性如何帮助克服与编码简短的声音定位提示相关的独特计算挑战，嵌入了高频信号中。