ADULT NEUROGENESIS & VOCAL PLASTICITY IN SONGBIRDS

成人神经发生

• 批准号: 6293605
• 负责人: LUISA L SCOTT
• 金额: $ 3.53万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-02-09 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6293605
• 关键词: NMDA receptors; antimitotics; behavioral /social science research tag; bromodeoxyuridine; deafness; experimental brain lesion; in situ hybridization; learning; mature animal; memory; messenger RNA; motor neurons; neural information processing; neural plasticity; neural recruitment; neuroanatomy; neurobiology; neurogenesis; neurons; neuropsychology; prosencephalon; radiotracer; receptor expression; songbirds; vocal cords

DESCRIPTION:(adapted from applicant?s abstract) The addition of new neurons into an established neural pathway may facilitate behavioral plasticity but also require training to be behaviorally adaptive. In adult songbirds, species differences in the extent of neuronal incorporation correlate with differences in song degradation after adult deafening, and the aim of the proposed experiments is to test further this relationship between neuron addition and behavioral plasticity. First, an antimitotic agent will be used to attenuate neuron addition and then determine if this attenuates behavioral change after deafening. Second, behavioral plasticity after deafening will be prevented by lesioning a specific part of the avian song system, and it will be determined if this manipulation also attenuates the addition of new vocal motor neurons. Third, adult-generated neurons will be labelled with bromodeoxyuridine and in situ hybridization will be used to determine if the expression of NMDA receptor mRNAs in these neurons recapitualtes maturational changes associated with periods of enhanced plasticity during development. These experiments will elucidate how the addition of new neurons in adulthood affects behavior, and will shed light on the consequences of endogenously and exogenously promoted neurogenesis and neuronal recruitment in humans.

描述：（改编自申请人的摘要） 将新神经元添加到已建立的神经途径中可能有助于 行为可塑性，但也需要训练在行为上是适应性的。在 成人鸣禽，神经元掺入程度的物种差异 与成年后的歌曲退化差异相关，而 提议的实验的目的是进一步测试 神经元的添加和行为可塑性。首先，抗魔法剂将是 用于减弱神经元的添加，然后确定这是否减弱 聋哑后行为改变。第二，行为可塑性之后 通过将雅芳歌曲的特定部分抛弃，可以防止震耳欲聋 系统，将确定这种操作是否也会减弱 添加新的声带神经元。第三，成人生成的神经元将是 用溴脱氧尿苷和原位杂交标记 确定NMDA受体mRNA在这些神经元中的表达是否 与增强时期相关的概括性变化 开发过程中的可塑性。这些实验将阐明 在成年中增加新神经元会影响行为，并将揭示 内源和外源促进神经发生和 人类的神经元招募。