Cortical Planning and Control of Smooth Pursuit

平滑追踪的皮质规划与控制

• 批准号: 7123817
• 负责人: STEPHEN J HEINEN
• 金额: $ 33.65万
• 依托单位: SMITH-KETTLEWELL EYE RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-03-01 至 2008-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7123817
• 关键词: Macaca mulatta; behavior test; computer data analysis; computer program /software; electrophysiology; electrostimulus; microelectrodes; neural information processing; neurons; neuroregulation; oculomotor nuclei; single cell analysis; smooth pursuit eye movement; vision tests; visual cortex; visual fields; visual stimulus

DESCRIPTION (provided by applicant): Smooth pursuit is a voluntary eye movement that is used to view objects as they move. Although physiologists have studied many aspects of voluntary saccade control, most work on the neural control of pursuit has treated this system as if it responds reflexively to retinal-image motion. The pursuit system of primates is a sophisticated ocular movement system that has evolved to allow it to predict when and where an object will move, and to decide whether or not to pursue that object. The focus of the current grant period is to understand how the cortical eye fields cooperate to control voluntary smooth pursuit eye movements. Aims are to: 1. Compare the strength of predictive and retinal-image signals used by the cortical eye fields to execute a pursuit eye movement 2. Determine how the cortical eye fields interact to cancel a pursuit movement. 3. Determine how the decision is made to execute or cancel a pursuit movement. The results of these experiments should contribute to our knowledge of how the cortex moves the eyes to effectively view moving objects in the natural scene. The results of this work should provide basic data to facilitate diagnosis and treatment of disorders of vision such as strabismus and amblyopia, and to develop prosthetic devices to aid people who suffer from these disorders.

描述（由申请人提供）：平滑追击是一种自愿的眼动，用于在移动时查看对象。尽管生理学家研究了自愿扫视控制的许多方面，但大多数有关追踪神经控制的工作都对该系统进行了处理，就好像它对视网膜图像运动做出了反思。灵长类动物的追求系统是一种复杂的眼运动系统，它已经演变为允许其预测对象何时何地移动，并决定是否追求该对象。当前赠款期的重点是了解皮质眼场如何配合以控制自愿平稳的追捕眼动。目的是： 1。比较皮层眼场使用的预测性和视网膜图像信号的强度 2.确定皮质眼场如何相互作用以取消追捕运动。 3.确定如何做出执行或取消追捕运动的决定。 这些实验的结果应该有助于我们了解皮质如何移动眼睛以有效地观察自然场景中的移动物体。这项工作的结果应提供基本数据，以促进和治疗视力障碍，例如斜视和弱视，并开发假肢设备以帮助患有这些疾病的人。