2D Biomedical Hyperspectral Imager

二维生物医学高光谱成像仪

• 批准号: 6882875
• 负责人: GILBERTO ZAMORA
• 金额: $ 11.09万
• 依托单位: KESTREL CORPORATION
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-30 至 2006-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6882875
• 关键词: bioimaging /biomedical imaging; biomedical equipment development; clinical biomedical equipment; image processing; imaging /visualization /scanning; retinography; spectrometry

DESCRIPTION (provided by applicant): This proposal from the KESTREL CORPORATION offers a new three dimensional (two spatial, one spectral) hyperspectral imager for use in clinical and biomedical research applications. Kestrel's three dimensional hyperspectral retinal imager concepts merge two developing technologies, Fourier Transform hyperspectral imaging technology and integral field spectroscopy. The two technologies allow an imaged region to be spatially sampled in a two dimensional area while retaining the spectral information in each sample. These samples are then processed and reassembled to create a full three dimensional data cube containing two spatial dimensions with full spectral content of the selected area. The Specific Aims of this proposal are: Aim 1: Development of a laboratory proof of principle three-dimensional hyperspectral medical imager that collects two spatial dimensions and a full compliment of spectral data in a single exposure for medical in vivo use. Aim 2: Collection of characterization data to demonstrate that three dimensional hyperspectral images can be collected and to show the increased value of these data over what is available today. Applications for this technology exist across a wide range of biomedical imaging. The value of hyperspectral medical imaging and especially its application in ocular uses is slowly gaining recognition. However, the current implementation of these hyperspectral devices limits their transition to wide spread clinical and research in vivo uses because of the techniques employed in collecting a three dimensional data cube are for practical purposes unusable. The technology proposed offers the potential of overcoming this limitation. The initial objectives demonstrate the underlying optica technologies and engineering, and set the stage for addressing long term objectives that will be directed at introducing the technology into clinical research prototype devices, such as an optical molecular imaging or an endoscope, and documenting the value of three dimensional data in these applications.

描述（由申请人提供）： KESTREL CORPORATION 的这项提案提供了一种新型三维（两个空间，一个光谱）高光谱成像仪，用于临床和生物医学研究应用。 Kestrel 的三维高光谱视网膜成像仪概念融合了两项正在开发的技术：傅里叶变换高光谱成像技术和积分场光谱技术。这两种技术允许在二维区域中对成像区域进行空间采样，同时保留每个样本中的光谱信息。然后对这些样本进行处理和重新组装，以创建一个完整的三维数据立方体，其中包含两个空间维度以及所选区域的完整光谱内容。 该提案的具体目标是： 目标 1：开发原理性三维高光谱医学成像仪的实验室验证，该成像仪可​​在单次曝光中收集两个空间维度和完整的光谱数据，供医学体内使用。 目标 2：收集表征数据，以证明可以收集三维高光谱图像，并显示这些数据相对于现有数据的更高价值。 该技术广泛应用于生物医学成像领域。高光谱医学成像的价值，特别是其在眼科应用中的应用正在慢慢获得认可。然而，这些高光谱设备的当前实施限制了它们向广泛的临床和体内研究用途的转变，因为收集三维数据立方体所采用的技术无法用于实际目的。所提出的技术提供了克服这一限制的潜力。最初的目标展示了基础光学技术和工程，并为实现长期目标奠定了基础，这些目标旨在将该技术引入临床研究原型设备，例如光学分子成像或内窥镜，并记录三个技术的价值这些应用中的尺寸数据。