Depth Maps From Stereo Images of the Optic Disc-Phase II

视盘立体图像的深度图 - 第二阶段

• 批准号: 7114849
• 负责人: GILBERTO ZAMORA
• 金额: $ 35.11万
• 依托单位: KESTREL CORPORATION
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-06-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7114849
• 关键词: bioimaging /biomedical imaging; biomedical automation; computer assisted diagnosis; computer human interaction; computer program /software; computer system design /evaluation; diagnosis design /evaluation; diagnosis quality /standard; digital imaging; early diagnosis; eye fundus photography; glaucoma; glaucoma test; human data; image enhancement; intraocular pressure; mathematical model; optic disk; phantom model; retina; three dimensional imaging /topography; visual fields

It is estimated that 3 million Americans have glaucoma,and 67 million peopleworldwidewill have glaucomaby2005. At least half do not know they have it because glaucoma usually has no symptoms in the early stages. Current research is aimed at developing methods of early diagnosis to detect the disease in the early stages, when treatment is most effective in minimizing irreversible vision loss. The identification of early pathologic changes at the Optic Nerve Head (ONH) is crucial to the diagnosis of glaucoma. The current gold standard for measuring these changes is through clinical stereoscopic observation of the ONH. From the American Academy of Ophthalmology (AAO) 2000, "Previous studies have found that the diagnostic precision of qualitative evaluation of stereoscopic ONHphotographs by experienced clinical observers is superior to any other currently available method of optic disc assessment" (Identifying Early Glaucomatous Changes, Wollstein, Health, 2000 AAOO). The major drawback to the stereoscopic evaluation is the subjectivity that creates inter- and intra-reader observer variability. A new method for evaluating the stereoscopic photographs is needed for consistent analysis of the changes on the ONH. This can be brought about by the use of quantitative analysis of the ONH changes. The Phase I project demonstrated a technique for calculating 3-dimensional topology of the ONH based on a pair of stereoscopic images. High correlations (> 0.9) between the manually annotated cup and disc and the automatically generated iso-disparity contours was documented. The principal aim of Phase II is to validate the technique by performing correlations with multiple readers and with existing clinical instruments such as the Heidelberg Retina Tomographer (HRT), and GDx Nerve Fiber Analyzer. The disparity algorithm's accuracy will be evaluated based on a phantom in the form of a model retina which has been machined with precise optic disc-like features. Such phantoms are used in radiology to calibrate tomography equipment. A second aim of the Phase II is to develop an interface for the use of the algorithm and to be tested in a clinical environment to demonstrate the software as a commercial grade product. Data for testing and validation will consist of traditional stereo fundus photography, digital stimultaneous photography, GDx nerve fiber analyzer, HRT,Goldman and Humphrey visual fields, and Inter Occular Pressure.

据估计，到2005年，有300万美国人患有青光眼，而全世界将有6700万人患有青光眼。至少有一半人不知道自己患有青光眼，因为青光眼在早期阶段通常没有任何症状。目前的研究旨在开发早期诊断方法，以便在早期阶段发现疾病，此时治疗对于最大限度地减少不可逆转的视力丧失最为有效。识别视神经乳头 (ONH) 的早期病理变化对于青光眼的诊断至关重要。目前测量这些变化的黄金标准是通过 ONH 的临床立体观察。美国眼科学会 (AAO) 2000 年指出，“之前的研究发现，由经验丰富的临床观察者对立体 ONH 照片进行定性评估的诊断精度优于任何其他现有的视神经盘评估方法”（识别早期青光眼变化，Wollstein ，健康，2000 AAOO）。立体评估的主要缺点是主观性会造成读者观察者之间和读者内部的差异。需要一种评估立体照片的新方法来对变化进行一致分析 在ONH上。这可以通过使用ONH变化的定量分析来实现。第一阶段项目展示了一种基于一对立体图像计算 ONH 3 维拓扑的技术。手动注释的杯和盘与自动生成的等视差之间具有高相关性 (> 0.9) 轮廓被记录下来。第二阶段的主要目的是通过与多个读者进行关联来验证该技术 使用现有的临床仪器，如海德堡视网膜断层扫描仪 (HRT) 和 GDx 神经纤维分析仪。视差算法的准确性将基于模型视网膜形式的模型进行评估，该模型已加工有精确的视神经盘状特征。这种模型在放射学中用于校准断层扫描设备。第二阶段的第二个目标是开发一个使用该算法的界面，并在临床环境中进行测试，以证明该软件是商业级产品。用于测试和验证的数据将包括传统立体眼底摄影、数字刺激摄影、GDx神经纤维分析仪、HRT、Goldman和Humphrey视野以及眼压。