Cardiorespiratory Fitness in Alzheimer's Disease

阿尔茨海默病的心肺健康

• 批准号: 6956080
• 负责人: JEFFREY Murray BURNS
• 金额: $ 6万
• 依托单位: UNIVERSITY OF KANSAS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-08-15 至 2007-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6956080
• 关键词: Alzheimer' s disease; aerobic exercise; aging; behavioral /social science research tag; bioimaging /biomedical imaging; body composition; brain imaging /visualization /scanning; brain morphology; cardiovascular disorder prevention; clinical research; cognition disorders; disease /disorder onset; hippocampus; human old age (65+); human subject; infarct; magnetic resonance imaging; mental disorder prevention; nervous system disorder epidemiology; neuropathology; oxygen consumption; psychological aspect of aging; psychological tests; white matter

DESCRIPTION (provided by applicant): Effective strategies for promoting healthy brain aging and preventing Alzheimer's disease (AD) are increasingly important given the growth of the elderly population and the resulting increase in the incidence of AD. Accumulating evidence suggests that exercise and cardiorespiratory (CR) fitness may protect against cognitive decline and age-related brain changes in non-demented aging. CR fitness has not been studied in the early stages of AD. Neuroimaging surrogate measures of brain aging and brain disease are increasingly used lo detect disease associations, explore causal mechanisms, and establish an intervention's disease-modifying effect. Thus, our long-term goal is to investigate CR fitness in AD and its relationship to structural brain changes associated with early-stage AD and non-demented aging. Our overall hypothesis is that increased CR fitness will be inversely associated with neuroimaging markers of brain aging. We will assess maximal oxygen consumption (VO2 max), the gold-standard measure of CR fitness, in a cohort (n = 64) of non-demented controls and early-stage AD subjects completing clinical and neuroimaging assessments as part of the University of Kansas (KU) Brain Aging Project. Brain aging markers include MRI measures of whole brain atrophy, hippocampal atrophy, white matter lesions, and infarcts. We will test our hypothesis with three specific aims. Aim 1: Assess for group differences in CR fitness in a cohort of non-demented controls and early-stage AD participants. Aim 2: Evaluate the relationship of CR fitness and hippocampal volume in non-demented aging and early-stage AD. Aim 3: Assess CR fitness in relation to MRI markers of brain aging: atrophy, white matter lesions, and infarcts. This preliminary, multidisciplinary study will generate cross-sectional pilot data assessing the relation between CR fitness, brain aging and AD-related brain injury. Utilizing well-characterized subjects with clinical and neuroimaging assessments through the KU Brain Aging Project enables this project to be feasible in a discrete time-frame. Exercise is already a key prevention strategy for health issues beyond preventing brain aging and cognitive decline. Despite this, an estimated 40-50 million adults in the US do not currently obtain the recommended amount of physical activity. A clear demonstration of the beneficial effects of exercise on brain aging and AD would be important for public health policy and effective for encouraging the public to adapt more active lifestyles. If our hypotheses are correct, we would pursue longitudinal interventional studies to better establish causality and assess increasing CR fitness as a way to promote healthy brain aging and moderate AD-related brain changes.

描述（由申请人提供）：鉴于老年人口的增长以及由此导致的 AD 发病率的增加，促进大脑健康老化和预防阿尔茨海默病 (AD) 的有效策略变得越来越重要。越来越多的证据表明，运动和心肺（CR）健身可以预防非痴呆衰老过程中的认知能力下降和与年龄相关的大脑变化。 AD 早期阶段的 CR 适应性尚未研究。脑衰老和脑疾病的神经影像替代指标越来越多地用于检测疾病关联、探索因果机制并建立干预措施的疾病缓解效果。因此，我们的长期目标是研究 AD 中的 CR 适应性及其与早期 AD 和非痴呆衰老相关的大脑结构变化的关系。我们的总体假设是，CR 适应性的增加与大脑衰老的神经影像标记物呈负相关。我们将在一组（n = 64）非痴呆对照组和早期 AD 受试者中评估最大耗氧量（VO2 max），这是 CR 健康的黄金标准衡量标准，作为大学的一部分，完成临床和神经影像学评估堪萨斯州 (KU) 脑老化项目。大脑老化标志物包括全脑萎缩、海马萎缩、白质病变和梗塞的 MRI 测量结果。我们将通过三个具体目标来检验我们的假设。目标 1：评估一组非痴呆对照组和早期 AD 参与者的 CR 适应性的群体差异。目标 2：评估非痴呆衰老和早期 AD 中 CR 适应性与海马体积的关系。目标 3：评估与大脑老化 MRI 标志物相关的 CR 适应性：萎缩、白质病变和梗塞。这项初步的多学科研究将产生横断面试点数据，评估 CR 健康、大脑衰老和 AD 相关脑损伤之间的关系。通过 KU 脑老化项目利用具有良好特征的受试者进行临床和神经影像评估，使该项目在离散的时间范围内可行。除了防止大脑衰老和认知能力下降之外，锻炼已经成为健康问题的重要预防策略。尽管如此，估计美国有 40-5000 万成年人目前没有获得建议的身体活动量。明确证明运动对大脑衰老和 AD 的有益影响对于公共卫生政策非常重要，并且可以有效鼓励公众适应更积极的生活方式。如果我们的假设是正确的，我们将进行纵向介入研究，以更好地确定因果关系并评估增加 CR 适应性，以此作为促进健康大脑老化和适度 AD 相关大脑变化的一种方式。