VITAMIN D METABOLITE, CALCITRIOL IN SCLERODERMA

硬皮病中的维生素 D 代谢物、骨化三醇

• 批准号: 6265151
• 负责人: JACQUES LEMIRE
• 金额: $ 1.15万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6265151
• 关键词: 1,25 dihydroxycholecalciferol; clinical research; contracture; cytotoxicity; elasticity; human subject; human therapy evaluation; immune system; lung; respiratory function; scleroderma; skin disorder chemotherapy; steroid hormone metabolism; steroid metabolism; vitamin D

Determine if active vitamin D metabolite, calcitrol, can be a beneficial therapeutic agent in the treatment of scleroderma. The effect on skin elasticity, thickening, contractures, pulmonary function will be tested. Therpeutic efficacy without toxicity and effect on immune pathways will be evaluated.

确定活性维生素D代谢产物（钙钛酚）是否可以成为硬皮病治疗的有益治疗剂。 将测试对皮肤弹性，增厚，染色，肺功能的影响。将评估没有毒性的治疗功效，并将评估对免疫途径的影响。