ShEEP request for IVIS SpectrumCT Imaging System

SheEEP 请求 IVIS SpectrumCT 成像系统

• 批准号: 9794239
• 负责人: SUBBURAMAN MOHAN
• 金额: --
• 依托单位: VA LOMA LINDA HEALTHCARE SYSTEM
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-01-01 至 2019-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9794239
• 关键词: 3-Dimensional; Anatomy; Animal Model; Animals; Applications Grants; Area; Biological Process; Bioluminescence; Bone Resorption; Computer software; Data; Degenerative polyarthritis; Detection; Development; Disease; Disease Progression; Documentation; Dose; Equipment; Fee-for-Service Plans; Fluorescence; Fluorochrome; Funding; Genes; Grant; Healthcare Systems; Image; Lighting; Longitudinal Studies; Low Dose Radiation; Measures; Medical center; Mission; Modality; Molecular; Monitor; Motion; Mus; Musculoskeletal; Musculoskeletal Diseases; Optics; Osteogenesis; Osteoporosis; Pathogenesis; Performance; Phenotype; Procedures; Publications; Research; Research Personnel; Resolution; Scanning; Services; Sheep; Signal Transduction; Small Animal Imaging Systems; Source; Speed; Surface; System; Time; Time Study; Tissues; Transillumination; Traumatic Brain Injury; Treatment outcome; United States National Institutes of Health; Universities; Veterans; Work; animal imaging; cell motility; cherenkov imaging; clinical optical imaging; complex biological systems; detector; experimental study; faculty research; fluorescence imaging; hearing impairment; imaging facilities; imaging software; imaging study; imaging system; in vivo; in vivo imaging system; in vivo optical imaging; insight; instrument; luminescence; microCT; operation; optical imaging; pre-clinical; protein function; reconstruction; screening; spatiotemporal; tomography; tool

In this ShEEP grant, we request funds to purchase a preclinical in vivo imaging system from Perkin Elmer for installation in the phenotype core of the Musculoskeletal Disease Center of VA Loma Linda Healthcare System (VALLHCS). The IVIS SpectrumCT from Perkin Elmer is an integrated premier optical imaging and low-dose microCT that enables simultaneous molecular and anatomical longitudinal studies, providing researchers with essential insights into complex biological systems in small animal models. The constant horizontal gantry motion and the flat panel detector provide outstanding performance for low-dose imaging and automated optical and microCT integration. The stable revolving animal platform rotates 360o enabling acquisition of full 3D data. Another feature of this system is that multiple animals can be scanned simultaneously while maintaining an average dose per scan at 1.3 Gy, with scanning and reconstruction time of less than a minute. The system also allows operation of optical and microCT modalities independently. The IVIS SpectrumCT allows for true topographic surface mapping of the animal and the included workflow and imaging wizard features facilitate procedures for 3D tomography and 2D screening modes in bioluminescence, fluorescence and Cerenkov luminescence. This new instrument will be used by a number of investigators at the VALLHCS to perform in vivo small animal imaging work. The applications include but are not limited to experiments proposed in various funded studies that will benefit immensely by the availability of this in vivo optical imaging system. The software that comes with the system allows automated and precise quantitation of the various fluorescent signals employed. The system also allows for obtaining high quality images for data documentation and publication. A number of VA, DOD and NIH funded investigators at this VA Medical Center including Drs. Mohan, Lau, Rundle, Qin, Dong, Xing, Li and Edderkaoui require this equipment to perform studies related to their funded grant applications. Currently, no in vivo imaging system for small animals is available for research use at VALLHCS. The requested instrument is needed for successful completion of funded studies that are relevant to the pathogenesis and treatment of osteoporosis, osteoarthritis and hearing loss, diseases that are target areas of the VA research mission.

在这项 ShEEP 拨款中，我们请求资金从以下公司购买临床前体内成像系统： Perkin Elmer 安装在 VA 肌肉骨骼疾病中心的表型核心中 洛马琳达医疗保健系统 (VALLHCS)。 Perkin Elmer 的 IVIS SpectrumCT 是一款 集成一流的光学成像和低剂量 microCT，可实现同步分子 和解剖纵向研究，为研究人员提供了对复杂的重要见解 小动物模型中的生物系统。恒定的水平龙门运动和平坦 面板探测器为低剂量成像和自动光学和 显微 CT 集成。稳定的旋转动物平台可 360° 旋转，从而获得完整的 3D 数据。该系统的另一个特点是可以同时扫描多个动物 同时保持每次扫描的平均剂量为 1.3 Gy，扫描和重建时间为 不到一分钟。该系统还允许操作光学和 microCT 模式 独立。 IVIS SpectrumCT 可对动物进行真实的地形表面测绘 所包含的工作流程和成像向导功能简化了 3D 断层扫描程序 生物发光、荧光和切伦科夫发光的 2D 筛选模式。这 VALLHCS 的许多研究人员将使用新仪器进行体内小型研究 动物成像工作。应用包括但不限于中提出的实验 各种资助的研究将因这种体内光学成像的可用性而受益匪浅 系统。系统附带的软件可以自动、精确地定量 使用的各种荧光信号。该系统还允许获得高质量 用于数据记录和发布的图像。许多 VA、DOD 和 NIH 资助 该退伍军人管理局医疗中心的研究人员，包括博士。莫涵、刘、润德尔、秦、董、兴、李 和 Edderkaoui 需要该设备来进行与其资助的赠款相关的研究 应用程序。目前尚无小动物活体成像系统可供研究使用 在VALLHCS。成功完成资助的研究需要所请求的仪器 与骨质疏松症、骨关节炎和听力的发病机制和治疗相关的 损失、疾病是退伍军人管理局研究任务的目标领域。