Novel surface treatment of fillers for dental composites

牙科复合材料填料的新型表面处理

• 批准号: 6920891
• 负责人: JEFFREY W. STANSBURY
• 金额: $ 22.56万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6920891
• 关键词: biomaterial compatibility; biomaterial development /preparation; biomaterial evaluation; biomaterial interface interaction; biotechnology; composite resins; dental adhesive /sealant; dental amalgam; dental caries; polymers; polymethacrylate; silanes; surface coating; tooth filling

DESCRIPTION (provided by applicant):The restoration of carious portions of otherwise sound teeth will continue to be a central focus of Dentistry into the foreseeable future. In spite of the significant improvements in composites over the last few decades, the projected service life of composite materials remains considerably less than that of Dental amalgams. Critical composite materials limitations are associated with shrinkage stress development during resin matrix formation and the establishment and long-term durability of the attachment between resin and filler. While many of the advances in composites have come from the selection of filler composition and particle size, the coupling agent interface between the resin and filler has received remarkably little attention. This proposed investigation will develop and evaluate the potential of an interfacial region that is dramatically different from that available with the conventional gamma-methacryloxypropyltrimethoxysilane used in Dental composites. In Specific Aim 1: controlled concentrations of functionalized silanes lacking polymerizable methacrylate groups will be applied to yield efficient surface coverage of small particle filler and microfiller. The silanization process will be studied in detail since significantly different application procedures can be used in the absence of methacrylate groups. In Specific Aim 2: the appended functionality will be used to covalently attach preformed oligomeric/polymeric chains. The surface-tethered chains can be significantly varied in terms of hydrophobicity, flexibility and length. In Specific Aim 3: the polymer brush surface-modified fillers will be formulated with traditional methacrylate-based Dental resins and the resulting composites will be evaluated with the reasonable expectation that the alternative coupling agents developed here will provide efficient and stable resin-filler attachment through both physical entanglements and direct copolymerization. Significant improvements are posited in composite materials based on higher filler loading, greater hydrolytic stability, increased wear resistance, improved fracture toughness and reduced polymerization shrinkage stress; all without compromise to mechanical strength properties. While the coupling agent makes up only a smell fraction of the Dental composite formulation, there appears to be substantial, clinically relevant benefits in composite performance that can potentially be obtained by changes in this interfacial region. Positive preliminary data offer encouragement that this nanotechnology approach to the resin-filler interface can provide broadly applicable enhancements in function and longevity of widely used Dental restoratives.

描述（由申请人提供）：在可预见的未来，修复原本健康的牙齿的龋齿部分将继续成为牙科的中心焦点。尽管过去几十年来复合材料取得了显着改进，但复合材料的预计使用寿命仍然大大低于牙科汞合金。复合材料的关键限制与树脂基体形成过程中收缩应力的发展以及树脂和填料之间附着力的建立和长期耐久性有关。虽然复合材料的许多进步来自于填料组成和粒径的选择，但树脂和填料之间的偶联剂界面却很少受到关注。这项拟议的研究将开发和评估界面区域的潜力，该界面区域与牙科复合材料中使用的传统γ-甲基丙烯酰氧基丙基三甲氧基硅烷的界面区域显着不同。具体目标 1：将采用受控浓度的不含可聚合甲基丙烯酸酯基团的官能化硅烷，以产生小颗粒填料和微填料的有效表面覆盖。将详细研究硅烷化过程，因为在不存在甲基丙烯酸酯基团的情况下可以使用显着不同的施涂程序。在具体目标 2 中：附加的官能团将用于共价连接预先形成的低聚/聚合链。表面束缚链在疏水性、柔韧性和长度方面可以显着变化。具体目标 3：聚合物刷表面改性填料将与传统的基于甲基丙烯酸酯的牙科树脂一起配制，并对所得复合材料进行评估，合理预期此处开发的替代偶联剂将通过以下方式提供有效且稳定的树脂-填料附着：物理缠结和直接共聚。复合材料的显着改进基于更高的填料含量、更高的水解稳定性、更高的耐磨性、更高的断裂韧性和更低的聚合收缩应力；所有这些都不会影响机械强度特性。虽然偶联剂仅占牙科复合材料配方的一小部分，但通过改变该界面区域可以潜在地获得复合材料性能方面的实质性临床相关益处。积极的初步数据表明，这种树脂-填料界面纳米技术方法可以广泛应用，增强广泛使用的牙科修复材料的功能和寿命。