Monomers and nanogel to improve adhesive resin structural integrity/durability

用于提高粘合剂树脂结构完整性/耐久性的单体和纳米凝胶

• 批准号: 8669964
• 负责人: JEFFREY W. STANSBURY
• 金额: $ 35.6万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-07-01 至 2018-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8669964
• 关键词: Address; Adherence; Adhesions; Adhesives; Affect; Ammonium; Anti-Bacterial Agents; Attention; Binding Sites; Chemicals; Chemistry; Child; Clinical; Clinical Research; Collagen; Coupled; Dental; Dental Amalgam; Dental Enamel; Dental caries; Dentin; Dentists; Deterioration; Development Plans; Devices; Disease; Drug Formulations; Equilibrium; Esthetics; Failure; Fluorescent Probes; General Population; General Practices; General Practitioners; Generations; Generic Drugs; Goals; Hybrids; Image; Imaging Techniques; Life; Link; Location; Longevity; Matrix Metalloproteinases; Mechanics; Methods; NanoGel; Oral health; Outcome; Patients; Performance; Phase; Plant Resins; Polymers; Procedures; Process; Production; Property; Protocols documentation; Psychological reinforcement; Reliance; Resistance; Services; Sodium Chloride; Structure; System; Techniques; Time; Tooth structure; Uncertainty; Visit; Water; adhesive polymer; analytical tool; base; composite restoration; crosslink; density; dental adhesive; design; improved; monomer; nano; nanomechanical; nanoscale; novel; novel strategies; particle; polymerization; public health relevance; restoration; restorative composite; restorative dentistry; restorative treatment; seal; small molecule; sound; success; uptake

DESCRIPTION (provided by applicant): With a majority of the more than 100,000 million dental restorative treatments performed in the US each year involving the placement of resin-bonded composite materials, and the acknowledgement that a large portion of a dentist's time is consumed with revising and replacing these restorations, there is a clear need for materials with improved clinical performance. Composite restoratives not only hold an esthetic advantage over dental amalgams, but they offer a means to adhesively bond the restoration to dentin and enamel. However, due to challenges imposed by wet bonding techniques, the potential for water-induced phase separation prior to, during or over extended intervals following polymerization of this critical interface, a strong, intact margin cannot currently be reliably obtained. This proposal describes the development plan for new water compatible monomers that compared with HEMA, offer the potential for improved reactivity, avoidance of phase separation and the production of chemically and mechanically sound polymer networks. A highly versatile technique has been developed for preparing nano-scale (10 - 30 nm) polymeric particles with control over branching, chemistry and reactive site placement. These reactive nanogels can be dispersed readily at high concentrations in secondary monomers, which then infiltrate and subsequently copolymerize with the prepolymer additives. The proposed project is constructed around three specific aims: 1) water-compatible monomers as alternatives to or in addition to HEMA will be developed as a means to better maintain homogeneity and high crosslink densities throughout adhesive resins; 2) the positive preliminary results with nanogel-modified adhesives will be extended into water-dispersible reactive nanogels that provide enhanced structural homogeneity and stability while introducing components that cannot be dispersed in water as free monomers; and 3) micro/nano-mechanical property characterization coupled with imaging of the adhesive layer and interfaces will be collectively used as an analytical tool to better understand structure and properties associated with the interaction between dentin and the adhesive resin in existing materials as well as the advanced adhesives proposed here. We expect to correlate the stabilization of the adhesive resin phase with collagen protection strategies that include collagen crosslinking, anti-bacterial activity and MMP-inhibiting properties based on the non-migrating nanogel platform. The application will provide an improved understanding of the strengths and weaknesses of existing adhesive systems, while developing new materials that address the significant current problems of structural stability and durability within the adhesive and hybrid layers of bonded dental restorations.

描述（由申请人提供）：美国每年进行的超过 1000 亿次牙科修复治疗中，大部分都涉及放置树脂粘合复合材料，并且承认牙医的大部分时间都花在了修改上为了取代这些修复体，显然需要具有改善临床性能的材料。复合修复体不仅比牙科汞合金具有美观优势，而且提供了一种将修复体粘合到牙本质和牙釉质的方法。然而，由于湿法粘合技术带来的挑战，在该关键界面聚合之前、期间或之后的较长时间间隔内可能发生水引起的相分离，目前无法可靠地获得牢固、完整的边缘。该提案描述了新型水相容性单体的开发计划，与 HEMA 相比，该单体具有提高反应性、避免相分离以及生产化学和机械性能良好的聚合物网络的潜力。已经开发出一种高度通用的技术，用于制备纳米级（10 - 30 nm）聚合物颗粒，并控制支化、化学和反应位点的放置。这些反应性纳米凝胶可以很容易地以高浓度分散在第二单体中，然后渗透并随后与预聚物添加剂共聚。拟议项目围绕三个具体目标构建：1）将开发水相容单体作为 HEMA 的替代品或补充，以更好地保持整个粘合剂树脂的均匀性和高交联密度； 2) 纳米凝胶改性粘合剂的积极初步结果将扩展到水分散性反应性纳米凝胶，其提供增强的结构均匀性和稳定性，同时引入不能作为游离单体分散在水中的组分； 3）微/纳米机械性能表征与粘合层和界面的成像相结合将被共同用作分析工具，以更好地了解与现有材料中牙本质和粘合树脂之间相互作用相关的结构和性能以及这里提出了先进的粘合剂。我们期望将粘合树脂相的稳定性与胶原蛋白保护策略联系起来，包括基于非迁移纳米凝胶平台的胶原蛋白交联、抗菌活性和 MMP 抑制特性。该应用将加深对现有粘合系统的优点和缺点的了解，同时开发新材料，解决当前粘合牙科修复体的粘合层和混合层中结构稳定性和耐用性的重大问题。