TNF ALPHA AND ABNORMAL INSULIN SECRETION IN POLYCYSTIC OVARY SYNDROME

多囊卵巢综合征中的 TNF α 和胰岛素分泌异常

• 批准号: 7202706
• 负责人: FRANK GONZALEZ
• 金额: $ 2.43万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-04-01 至 2006-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7202706
• 关键词: clinical research; human subject

DESCRIPTION: (provided by applicant) The purpose of this application to seek funding for the renewal of the General Clinical Research Center (GCRC) at Case Western Reserve University (CWRU) School of Medicine. The main GCRC is located at University Hospitals of Cleveland with a satellite at MetroHealth Medical Center (MHMC). In 2002, the GCRC supported 166 protocols for 90 principal investigators representing multiple schools, departments and divisions of CWRU, the Department of Cell Biology at the Cleveland Clinic Foundation, and the Department of Nutrition and Exercise Physiology at Cleveland State University. As a research institute, CWRU's School of Medicine has maintained a tradition of national leadership, including claim to 12 Nobel laureates among its alumni (5) and faculty (7). There are 1,493 full time faculty in the medical school. In 2001, CWRU researchers were funded over $174,000,000 by NIH. These awards include major funding for research in cancer, AIDS, diabetes, cystic fibrosis, hypertension, TB, skin diseases, Alzheimer's disease, cartilage regeneration, airway diseases, neonatal and adult metabolism, functional electric stimulation, perinatal medicine, and genetics defects of various types among others. Fifty-seven CWRU researchers were awarded more than $1 million in NIH support in 2002. In 2002, CWRU ranked 16th among the nations 126 medical schools in NIH support. Fifteen of the school's departments ranked in the top 20 of the corresponding departments. Compared to the last five year renewal, there has been a 17% increase in the number of GCRC investigators and 81% increase in number of protocols utilizing the GCRC which resulted in a 97% increase in the number of publications (from 201). The major areas of research include: 1. Biochemical and molecular enhancement of cancer chemotherapy. 2. Electronic restoration of movement in spinal cord injury and stroke. 3. Molecular biology and treatment of cystic fibrosis. 4. Carbohydrate and protein metabolism in pregnancy. 5. Epidemiology, genetics, and pathophysiology of sleep-disordered breathing. 6. Pathophysiology and renal outcomes of human hypertension. 7. Factors affecting feto-placental growth and development. 8. Pathophysiology and treatment of HIV diseases.

描述：（由申请人提供）本申请的目的是为凯斯西储大学 (CWRU) 医学院普通临床研究中心 (GCRC) 的更新寻求资金。主要的 GCRC 位于克利夫兰大学医院，卫星中心位于 MetroHealth 医疗中心 (MHMC)。 2002 年，GCRC 支持了 90 名主要研究人员的 166 项方案，这些研究人员代表 CWRU 的多个学校、部门和部门、克利夫兰诊所基金会细胞生物学系以及营养和健康系。 克利夫兰州立大学运动生理学。作为一所研究机构，CWRU 医学院一直保持着国家领导的传统，其中包括其校友（5 名）和教师（7 名）中拥有 12 名诺贝尔奖获得者。医学院有1,493名全职教师。 2001 年，CWRU 研究人员获得 NIH 超过 1.74 亿美元的资助。这些奖项包括主要资助癌症、艾滋病、糖尿病、囊性纤维化、高血压、结核病、皮肤病、阿尔茨海默病、软骨再生、气道疾病、新生儿和成人新陈代谢、功能性电刺激、围产期医学以及各种遗传缺陷的研究。类型等。 2002年，57名CWRU研究人员获得了NIH超过100万美元的资助。2002年，CWRU在NIH资助方面在全国126所医学院中排名第16位。学校有15个院系排名进入相应院系前20名。与上一个五年续订相比，GCRC 调查人员数量增加了 17%，利用 GCRC 的协议数量增加了 81%，这导致出版物数量增加了 97%（从 201 份开始）。主要研究领域包括： 1.癌症化疗的生化和分子增强。 2. 脊髓损伤和中风运动的电子恢复。 3.囊性纤维化的分子生物学和治疗。 4.妊娠期碳水化合物和蛋白质代谢。 5. 睡眠呼吸障碍的流行病学、遗传学和病理生理学。 6. 人类高血压的病理生理学和肾脏结局。 7.影响胎儿胎盘生长发育的因素。 8. HIV疾病的病理生理学和治疗。