OLDER PERSONS AND DRUGS: RACE, GENDER AND AGE EFFECTS

老年人与毒品：种族、性别和年龄的影响

• 批准号: 7202636
• 负责人: JANICE B SCHWARTZ
• 金额: $ 0.09万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-04-01 至 2006-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7202636
• 关键词: clinical research; human subject

DESCRIPTION (provided by applicant): We have now completed three years of a four-year cycle. The primary aim of the new program direction team of the GCRC during this time was to address shortcomings identified in previous reviews and to continue to build our program for the future. We have completed the renovation of our inpatient unit and now have a state-of-the-art facility to conduct clinical research. We have relocated our Core Laboratory to new, updated and convenient space near the inpatient unit. We have improved our productivity in all spheres of activity, with steady growth in number of A days and visits, number of protocols, number and diversity of investigators, increased number of medical students and post-doctoral trainees on the unit and expansion of the scope of training activities. This has been accompanied by a substantial increase in publication productivity by GCRC investigators. Our new Research Subject Advocate (RSA) program has played an important role in assisting and educating GCRC investigators in the areas of research subject consent, safety monitoring and regualtory compliance. The Core Laboratory expanded its services in genomics and other DNA technologies, and our new Exercise Physiology and Body Composition Laboratory has been providing services to a growing number of investigators. The level of activiy and excitement on the GCRC has never been higher. In this competing renewal proposal, 66 different principal investigators will perform 89 protocols in several areas including genetic epidemiology of connective tissue diseases and other disorders, pharmacogenetics, dementia research, gene expression profiling in cancer, HIV natural history and pathogenesis, exercise physiology in chronic diseases, and metabolic research with an emphasis on pathogenesis and treatment obesity, hypertension, bone loss and diabetes mellitus. These complement several other already active programs including oncology and psychopharmacology of drug addiction. These areas cover many of the emerging critical health issues as the population ages. Our focus over the next 5 years will be to continue to expand training on the GCRC; continue to expand our protocol diversity; and invest in and expand new laboratory and informatics technologies to allow the GCRC investigators to meet the research challenges of the future. To this end, we are requesting new resources to expand our services in database design, genomics capabilities and exercise physiology. As we do so, we will continue to perform this research with the highest standards of patient care, ethics, safety and regulatory compliance.

描述（由申请人提供）：我们现在已经完成了三年的三年周期。 在此期间，GCRC新计划方向团队的主要目的是解决 以前的评论中发现的缺点，并继续为未来建立我们的计划。我们已经完成了住院单元的翻新，现在有一个最先进的设施 进行临床研究。我们已经将核心实验室搬到了住院单元附近的新，更新且方便的空间。我们已经提高了所有活动领域的生产率，并稳定地增长了一天的时间，访问，协议数量，研究人员的数量和多样性，增加医学生的数量和培训后培训人员，并扩大了培训活动范围。这伴随着GCRC研究人员的出版生产率大幅提高。我们的新研究主题倡导者（RSA）计划在协助和教育研究主题同意，安全监控和重新遵守方面的GCRC研究人员方面发挥了重要作用。核心实验室扩展了其在基因组学和其他DNA技术方面的服务，我们的新运动生理学和身体组成实验室一直在为越来越多的研究人员提供服务。 GCRC上的活动和兴奋的水平从未如此高。 In this competing renewal proposal, 66 different principal investigators will perform 89 protocols in several areas including genetic epidemiology of connective tissue diseases and other disorders, pharmacogenetics, dementia research, gene expression profiling in cancer, HIV natural history and pathogenesis, exercise physiology in chronic diseases, and metabolic research with an emphasis on pathogenesis and treatment obesity, hypertension, bone loss and糖尿病。这些补充了其他一些已经活跃的计划，包括肿瘤学和吸毒成瘾的心理药理。随着人口年龄的增长，这些领域涵盖了许多新兴的关键健康问题。在接下来的5年中，我们的重点是继续扩大对GCRC的培训；继续扩大我们的协议多样性；并投资并扩展新的实验室和信息学技术，以使GCRC研究人员能够应对未来的研究挑战。为此，我们要求新资源在数据库设计，基因组学功能和 运动生理。这样做，我们将继续以最高的患者护理，道德，安全性和法规依从性进行这项研究。