Optimizing vitamin D in the elderly

优化老年人的维生素 D

• 批准号: 8726675
• 负责人: JANICE B SCHWARTZ
• 金额: $ 6.91万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-15 至 2015-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8726675
• 关键词: Aged, 80 and over; Albumins; Algorithms; American; Blinded; Bone Resorption; C-telopeptide; Cardiovascular Diseases; Characteristics; Cholecalciferol; Communities; Data; Diabetes Mellitus; Dose; Elderly; Environment; Fracture; Frail Elderly; Goals; Hormones; Immune System and Related Disorders; Incidence; Individual; Individual Differences; Inflammation; Inflammatory; Inflammatory Response Pathway; Investigation; Kidney Diseases; Life; Metabolic; Muscle Weakness; Nursing Homes; Oral; Osteoporosis; Parathyroid gland; Patients; Pharmaceutical Preparations; Population; Randomized; Recommendation; Regimen; Reporting; Research; Risk; Serum; Supplementation; Variant; Vitamin D; Vitamin D Deficiency; Vitamin D2; Vulnerable Populations; comparative efficacy; cytokine; dosage; falls; frailty; in vivo; nutrition; response

DESCRIPTION (provided by applicant): Vitamin D deficiency is highly prevalent in older people in the absence of vitamin D supplementation. The limited data available show marked inter-individual variability in response to vitamin D supplementation in very old, frail elderly wih almost 25% remaining vitamin D deficient (25-OH D < 20 ng/mL) when receiving the currently recommended 800 IU/day vitamin D. This proposal is for exploratory research on the use of a wide range of oral vitamin D3 doses in frail elderly living in controlled living environments. We will determine the dose response relationship of total and unbound 25- OH vitamin D3 to supplemental vitamin D3 at daily doses of 800 (currently recommended for the elderly), 2000, and 4000 IU or 50,000 IU/weekly in a randomized blinded investigation We will also compare the efficacy of each dosing regimen in achieving 25-OH vitamin D levels >20 ng/mL (50 nmol/L) and identify covariates that contribute to inter-individual variation in the dose response relationship. In patients with osteoporosis, relationships between unbound vs. total 25-OH on intact parathyroid hormone and a marker of bone resorption (beta-Ctx) will be analyzed. We will also examine responses of inflammatory cytokines. A long-term goal is to develop algorithms for estimation of D3 dosages to achieve target 25-OH vitamin D doses for very elderly and frail individuals.

描述（由申请人提供）：在不补充维生素D的情况下，老年人的维生素D缺乏症非常普遍。有限的可用数据显示，在接收当前推荐的800 IU/Day Vitamin D时，对维生素D补充维生素D的响应是显着的个体可变性。维生素D缺乏（25-OH D <20 ng/ml）。该建议是针对Oral Alal Enlive forner Allal veremin forsed frail frail frail frail frail frail frail frail frail frail frail frail frail dy3剂量的探索研究。 We will determine the dose response relationship of total and unbound 25- OH vitamin D3 to supplemental vitamin D3 at daily doses of 800 (currently recommended for the elderly), 2000, and 4000 IU or 50,000 IU/weekly in a randomized blinded investigation We will also compare the efficacy of each dosing regimen in achieving 25-OH vitamin D levels >20 ng/mL (50 nmol/L) and identify协变量有助于剂量反应关系中个体间变化。在骨质疏松症的患者中，将分析未结合的甲状旁腺激素与总25-OH之间的关系与骨吸收的标志（beta-CTX）。我们还将检查炎症细胞因子的反应。一个长期的目标是开发估计D3剂量的算法，以实现非常年轻和脆弱的个体的目标25-OH维生素D剂量。

项目成果

Primary prevention: do the very elderly require a different approach?

• DOI: 10.1016/j.tcm.2014.10.010
• 发表时间: 2015-04
• 期刊: Trends in cardiovascular medicine
• 影响因子: 9.3
• 作者: Schwartz JB