Synthesis and characterisation of mesoporous phosphate-based glasses for biomedical applications

用于生物医学应用的介孔磷酸盐玻璃的合成和表征

• 批准号: 2872452
• 金额: --
• 依托单位: University of Surrey
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2872452
• 关键词: Synthesis; characterisation; mesoporous; phosphate; based

This PhD project on the synthesis and characterisation of a new class of porous inorganic materials, will explore novel template strategies based on the sol-gel and coacervation processes for the synthesis of mesoporous phosphate-based glasses (MPG) with exceptionally high surface areas, tunable pore size and distribution. In particular, the proposal aims to synthetize sol-gel MPG with two dimensional (2D, hexagonal) channels of pores and three dimensional (3D, cubic) arrangements of interconnected pores in solution by using supramolecular chemistry. Highly porous materials are excellent candidates for biomedical applications, in particular for targeted delivery of therapeutic molecules/ions into the damaged site and simultaneous tissue regeneration (hard and soft). MPG will be embedded with antibacterial metallic ions (e.g. Ag+, Cu2+, Zn2+); ion release and antibacterial activities will be investigated and correlated with the porous structure. Compared to the current state of bioresorbable materials, an ordered arrangement of mesopores will facilitate the absorption and delivery of therapeutic ions and molecules.Structural and morphological characterization of the mesoporous nanocomposites will be investigated using a multi-technique approach involving surface/pore size and volume analysis via physisorption, thermal analysis, transmission and scanning electron microscopy (TEM/SEM), X-ray diffraction, and X-ray absorption diffraction/spectroscopy at synchrotron radiation facilities.Spanning across materials science, chemistry, biology and medicine, this proposal is truly multidisciplinary. The PhD candidate will develop a range of complementary skills in fabrication (sol-gel, supramolecular templating, coacervation), antibacterial testing and cutting-edge characterisation techniques in addition to unique training and expertise in measurements at the micro and nanoscale at NPL

该博士项目致力于新型多孔无机材料的合成和表征，将探索基于溶胶-凝胶和凝聚过程的新型模板策略，用于合成具有极高表面积、可调的介孔磷酸盐基玻璃（MPG）孔径和分布。特别是，该提案旨在利用超分子化学在溶液中合成具有二维（2D，六边形）孔道和三维（3D，立方）互连孔排列的溶胶-凝胶MPG。高多孔材料是生物医学应用的绝佳候选者，特别是用于将治疗分子/离子定向输送到受损部位并同时进行组织再生（硬组织和软组织）。 MPG将嵌入抗菌金属离子（例如Ag+、Cu2+、Zn2+）；将研究离子释放和抗菌活性并将其与多孔结构相关联。与目前的生物可吸收材料相比，介孔的有序排列将促进治疗离子和分子的吸收和传递。将使用涉及表面/孔径和体积的多种技术方法研究介孔纳米复合材料的结构和形态特征在同步加速器辐射设施中通过物理吸附、热分析、透射和扫描电子显微镜 (TEM/SEM)、X 射线衍射和 X 射线吸收衍射/光谱进行分析。该提案横跨材料科学、化学、生物学和医学，是真正的跨学科的。除了在 NPL 的微米和纳米尺度测量方面的独特培训和专业知识外，博士候选人还将开发一系列制造（溶胶-凝胶、超分子模板、凝聚）、抗菌测试和尖端表征技术方面的补充技能