Understanding interactions between minerals and small biopolymers under extreme conditions

了解极端条件下矿物质和小型生物聚合物之间的相互作用

• 批准号: 2870997
• 金额: --
• 依托单位: University of Edinburgh
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2870997
• 关键词: Understanding; interactions; between; minerals; small

This project combines computational screening and wet-lab experiments to develop a comprehensive understanding of the interactions between silicate minerals and small biologically-relevant molecules,such as amino acids, peptides, peptoids and proteins. Our goal is to study the stability of these organic molecules and their mineral-enabled adaptability to environmental conditions. We will focus onsampling the effects of salinity, ion compositions and pH at the extremes of environmental conditions. The project is data-driven, where the statistics obtained from molecular simulations will be used toguide the experimental studies. Such strategy allows us to establish a protocol where computational screening is used to sample mineral-bioorganic systems, informing and directing laboratory tests.

该项目结合了计算筛选和湿实验室实验，以全面了解硅酸盐矿物与生物相关小分子（如氨基酸、肽、类肽和蛋白质）之间的相互作用。我们的目标是研究这些有机分子的稳定性及其矿物对环境条件的适应性。我们将重点关注极端环境条件下盐度、离子组成和 pH 值的影响。该项目是数据驱动的，从分子模拟获得的统计数据将用于指导实验研究。这种策略使我们能够建立一个协议，其中使用计算筛选来对矿物-生物有机系统进行采样，从而通知和指导实验室测试。